21 relations: Alpha helix, Beta sheet, C-terminus, Capsid, Crystal structure, Disulfide, E2 (HCV), Endoplasmic reticulum, Genotype, Glycoprotein, Hepatitis C virus, Host (biology), Monomer, N-terminus, Protease, Protein dimer, Short hairpin RNA, Transmembrane domain, Transmembrane protein, Vaccine, Viral envelope.
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
A capsid is the protein shell of a virus.
In crystallography, crystal structure is a description of the ordered arrangement of atoms, ions or molecules in a crystalline material.
In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.
E2 is a viral structural protein found in the hepatitis C virus.
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
The genotype is the part of the genetic makeup of a cell, and therefore of an organism or individual, which determines one of its characteristics (phenotype).
Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to amino acid side-chains.
Hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae.
In biology and medicine, a host is an organism that harbours a parasitic, a mutualistic, or a commensalist guest (symbiont), the guest typically being provided with nourishment and shelter.
A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).
Transmembrane domain usually denotes a transmembrane segment of single alpha helix of a transmembrane protein.
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.
A vaccine is a biological preparation that provides active acquired immunity to a particular disease.
Some viruses (e.g. HIV and many animal viruses) have viral envelopes covering their protective protein capsids.