46 relations: Adenoviridae, Binding site, BRCA1, C-terminus, Caspase, Cdc6, Cell cycle, Cyclin, Cyclin A, Cyclin D, Cyclin-dependent kinase, Cyclin-dependent kinase 1, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Dihydrofolate reductase, DNA microarray, DNA polymerase, DNA repair, DNA-binding domain, Eukaryote, Growth factor, Histone, Histone deacetylase, Human papillomavirus infection, Mammal, MAPK/ERK pathway, MCM5, N-terminus, National Center for Biotechnology Information, P53, Phosphorylation, Pocket protein family, Polycomb-group proteins, Proliferating cell nuclear antigen, Promoter (genetics), Protein domain, Protein primary structure, Retinoblastoma protein, TFDP1, TFDP2, Thymidine kinase, Transcription factor, Transcription factor DP, Type 3c (Pancreatogenic) Diabetes, Winged-helix transcription factors, X-ray crystallography.
Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome.
In biochemistry, a binding site is a region on a protein or piece of DNA or RNA to which ligands (specific molecules and/or ions) may form a chemical bond.
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
Cdc6, or cell division cycle 6, is a protein in eukaryotic cells that is studied in the budding yeast Saccharomyces cerevisiae.
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.
Cyclin is a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (Cdk) enzymes.
Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle.
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression.
Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle.
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation.
Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene.
Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.
Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry.
A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface.
DNA polymerases are enzymes that synthesize DNA molecules from deoxyribonucleotides, the building blocks of DNA.
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.
Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes.
Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O.
Human papillomavirus infection is an infection by human papillomavirus (HPV).
Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
DNA replication licensing factor MCM5 is a protein that in humans is encoded by the MCM5 gene.
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
Pocket protein family consists of three proteins.
Polycomb-group proteins are a family of proteins first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place.
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
Protein primary structure is the linear sequence of amino acids in a peptide or protein.
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.
Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.
Transcription factor Dp-2 is a protein that in humans is encoded by the TFDP2 gene.
Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 18.104.22.168.
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
In molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors.
Type 3c diabetes (also known as Pancreatogenic diabetes) is a form of diabetes that is being researched.
Consisting of about 110 amino acids, the domain in winged-helix transcription factors (see Regulation of gene expression) has four helices and a two-strand beta-sheet.
X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.