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Endocrine disruptor

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Endocrine disruptors are chemicals that can interfere with endocrine (or hormone) systems at certain doses. [1]

152 relations: Agence France-Presse, Alkylphenol, Androgen, Androgen receptor, Animal, Animal rights, Anogenital distance, Antiandrogens in the environment, Antioxidant, Aroma compound, Atrazine, Attention deficit hyperactivity disorder, Autism, Bioaccumulation, Biological process, Biomagnification, Biomonitoring, Bis(2-ethylhexyl) phthalate, Bisphenol A, Bisphenol S, Breast cancer, Catherine Day, Childhood obesity, Chloracne, Clean Air Act (United States), Clean Water Act, Cognition, Colorado potato beetle, Copenhagen, Cysteamine, DDT, Denmark, Detergent, Diabetes mellitus, Dibutyl phthalate, Diethylstilbestrol, Dioxins and dioxin-like compounds, Dose–response relationship, Dysentery, Economic impact analysis, Elastomer, Endocrine Society, Endocrine system, Endogeny (biology), Endosulfan, Environmental Health Perspectives, Environmental Working Group, Estrogen, Estrogen receptor, Ethanolamine, ..., Ethinylestradiol, European Commission, European Union, Exogeny, Federal Food, Drug, and Cosmetic Act, Federal Insecticide, Fungicide, and Rodenticide Act, Feedback, Feminization (biology), Fetus, Fire retardant, Flame retardant, Food and Drug Administration, Food chain, Food Quality Protection Act, Genistein, Gland, Glucagon, Groundwater, Health Canada, Hormone, Insulin, JAMA (journal), John Sumpter, Kepone, Landfill, Learning disability, Lena Ek, Los Angeles Times, Lubricant, Malaria, Microplastics, Monoculture, Mycoestrogen, Natural Resources Defense Council, Neurotoxicity, Nonsteroidal, Nonylphenol, Nordic Council, Obesity, Obesogen, Off-label use, Old Order Mennonite, Organochloride, Oxybenzone, Paraben, Perfluorooctanoic acid, Persistent organic pollutant, Pesticide, Phenol formaldehyde resin, Phenols, Philippe Grandjean (professor), Phthalate, Phytoestrogens, Plastic, Plastics industry, Pollutant-induced abnormal behaviour, Polybrominated diphenyl ethers, Polychlorinated biphenyl, Polychlorinated dibenzofurans, Polycyclic aromatic hydrocarbon, Precautionary principle, Prostate cancer, Puberty, Pyrethrum, Receptor (biochemistry), Reproductive system, Safe Drinking Water Act, Science (journal), Serotonin, Sex ratio, Sex steroid, Stink!, Stockholm Convention on Persistent Organic Pollutants, Sweden, Tamoxifen, Textile, The dose makes the poison, The New York Times, Theo Colborn, Thyroid, Tin can, Toxic Substances Control Act of 1976, Transatlantic Trade and Investment Partnership, Tributyltin, Typhoid fever, Typhus, United Nations Environment Programme, United States Congress, United States Environmental Protection Agency, United States Office of Research Integrity, Utrecht University, Vaginal cancer, Vinclozolin, Virilization, Volatile organic compound, Whiteleg shrimp, World Health Organization, World War II, Xenoestrogen, Xenohormone, Yushō disease, Zearalenone. Expand index (102 more) »

Agence France-Presse

Agence France-Presse (AFP) is an international news agency headquartered in Paris, France.

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Alkylphenols are a family of organic compounds obtained by the alkylation of phenols.

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An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

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Androgen receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.

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Animals are multicellular eukaryotic organisms that form the biological kingdom Animalia.

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Animal rights

Animal rights is the idea in which some, or all, non-human animals are entitled to the possession of their own lives and that their most basic interests—such as the need to avoid suffering—should be afforded the same consideration as similar interests of human beings.

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Anogenital distance

Anogenital distance (AGD) is the distance from the anus to the genitalia, the base of the penis or vagina.

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Antiandrogens in the environment

Antiandrogens in the environment have become a topic of concern.

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Antioxidants are molecules that inhibit the oxidation of other molecules.

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Aroma compound

An aroma compound, also known as an odorant, aroma, fragrance, or flavor, is a chemical compound that has a smell or odor.

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Atrazine is a herbicide of the triazine class.

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Attention deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.

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Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.

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Bioaccumulation is the accumulation of substances, such as pesticides, or other chemicals in an organism.

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Biological process

Biological processes are the processes vital for a living organism to live.

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Biomagnification, also known as bioamplification or biological magnification, is the increasing concentration of a substance, such as a toxic chemical, in the tissues of tolerant organisms at successively higher levels in a food chain.

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In analytical chemistry, biomonitoring is the measurement of the body burden of toxic chemical compounds, elements, or their metabolites, in biological substances.

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Bis(2-ethylhexyl) phthalate

Bis(2-ethylhexyl) phthalate (di-2-ethylhexyl phthalate, diethylhexyl phthalate, DEHP; dioctyl phthalate, DOP) is an organic compound with the formula C6H4(CO2C8H17)2.

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Bisphenol A

Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups.

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Bisphenol S

Bisphenol S (BPS) is an organic compound with the formula (HOC6H4)2SO2.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Catherine Day

Catherine Day (born 16 June 1954 in Mount Merrion, Dublin) is a former Secretary-General of the European Commission.

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Childhood obesity

Childhood obesity is a condition where excess body fat negatively affects a child's health or well-being.

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Chloracne is an acne-like eruption of blackheads, cysts, and pustules associated with over-exposure to certain halogenated aromatic compounds, such as chlorinated dioxins and dibenzofurans.

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Clean Air Act (United States)

The Clean Air Act (42 U.S.C.) is a United States federal law designed to control air pollution on a national level.

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Clean Water Act

The Clean Water Act (CWA) is the primary federal law in the United States governing water pollution.

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Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

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Colorado potato beetle

The Colorado potato beetle (Leptinotarsa decemlineata), also known as the Colorado beetle, the ten-striped spearman, the ten-lined potato beetle or the potato bug, is a major pest of potato crops.

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Copenhagen (København; Hafnia) is the capital and most populous city of Denmark.

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Cysteamine is a medication intended for a number of indications, and approved by the FDA to treat cystinosis.

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Dichlorodiphenyltrichloroethane, commonly known as DDT, is a colorless, tasteless, and almost odorless crystalline chemical compound, an organochlorine, originally developed as an insecticide, and ultimately becoming infamous for its environmental impacts.

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Denmark (Danmark), officially the Kingdom of Denmark,Kongeriget Danmark,.

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A detergent is a surfactant or a mixture of surfactants with cleaning properties in dilute solutions.

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Diabetes mellitus

Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.

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Dibutyl phthalate

Dibutyl phthalate (DBP) is an organic compound commonly used plasticizer. With the chemical formula C6H4(CO2C4H9)2, it is a colorless oil, although commercial samples are often yellow. Because of its low toxicity and wide liquid range, it is used as a plasticizer.Peter M. Lorz, Friedrich K. Towae, Walter Enke, Rudolf Jäckh, Naresh Bhargava, Wolfgang Hillesheim "Phthalic Acid and Derivatives" in Ullmann's Encyclopedia of Industrial Chemistry, 2007, Wiley-VCH, Weinheim.

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Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is an estrogen medication which is mostly no longer used.

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Dioxins and dioxin-like compounds

Dioxins and dioxin-like compounds (DLCs) are compounds that are highly toxic environmental persistent organic pollutants (POPs).

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Dose–response relationship

The dose–response relationship, or exposure–response relationship, describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical) after a certain exposure time, or to a food.

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Dysentery is an inflammatory disease of the intestine, especially of the colon, which always results in severe diarrhea and abdominal pains.

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Economic impact analysis

An economic impact analysis (EIA) examines the effect of an event on the economy in a specified area, ranging from a single neighborhood to the entire globe.

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An elastomer is a polymer with viscoelasticity (i. e., both viscosity and elasticity) and very weak intermolecular forces, and generally low Young's modulus and high failure strain compared with other materials.

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Endocrine Society

The Endocrine Society is a professional, international medical organization in the field of endocrinology and metabolism, founded in 1916 as The Association for the Study of Internal Secretions.

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Endocrine system

The endocrine system is a chemical messenger system consisting of hormones, the group of glands of an organism that carry those hormones directly into the circulatory system to be carried towards distant target organs, and the feedback loops of homeostasis that the hormones drive.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

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Endosulfan is an off-patent organochlorine insecticide and acaricide that is being phased out globally.

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Environmental Health Perspectives

Environmental Health Perspectives (EHP) is a peer-reviewed journal published monthly with support from the U.S. National Institute of Environmental Health Sciences (NIEHS).

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Environmental Working Group

The Environmental Working Group (EWG) is an American environmental organization that specializes in research and advocacy in the areas of toxic chemicals, agricultural subsidies, public lands, and corporate accountability.

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Estrogen, or oestrogen, is the primary female sex hormone.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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Ethanolamine (2-aminoethanol, monoethanolamine, ETA, or MEA) is an organic chemical compound with the formula HOCH2CH2NH2.

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Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins.

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European Commission

The European Commission (EC) is an institution of the European Union, responsible for proposing legislation, implementing decisions, upholding the EU treaties and managing the day-to-day business of the EU.

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European Union

The European Union (EU) is a political and economic union of EUnum member states that are located primarily in Europe.

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In a variety of contexts, exogeny or exogeneity is the fact of an action or object originating externally.

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Federal Food, Drug, and Cosmetic Act

The United States Federal Food, Drug, and Cosmetic Act (abbreviated as FFDCA, FDCA, or FD&C), is a set of laws passed by Congress in 1938 giving authority to the U.S. Food and Drug Administration (FDA) to oversee the safety of food, drugs, and cosmetics.

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Federal Insecticide, Fungicide, and Rodenticide Act

The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) is a United States federal law that set up the basic U.S. system of pesticide regulation to protect applicators, consumers, and the environment.

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Feedback occurs when outputs of a system are routed back as inputs as part of a chain of cause-and-effect that forms a circuit or loop.

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Feminization (biology)

In biology and medicine, feminization is the development in an organism of physical characteristics that are usually unique to the female of the species.

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A fetus is a stage in the prenatal development of viviparous organisms.

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Fire retardant

A fire retardant is a substance that is used to slow or stop the spread of fire or reduce its intensity.

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Flame retardant

The term flame retardants subsumes a diverse group of chemicals which are added to manufactured materials, such as plastics and textiles, and surface finishes and coatings.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Food chain

A food chain is a linear network of links in a food web starting from producer organisms (such as grass or trees which use radiation from the Sun to make their food) and ending at apex predator species (like grizzly bears or killer whales), detritivores (like earthworms or woodlice), or decomposer species (such as fungi or bacteria).

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Food Quality Protection Act

The Food Quality Protection Act (FQPA), or H.R.1627, was passed unanimously by Congress in 1996 and was signed into law by President Bill Clinton on August 3, 1996.

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Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen.

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A gland is a group of cells in an animal's body that synthesizes substances (such as hormones) for release into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland).

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Glucagon is a peptide hormone, produced by alpha cells of the pancreas.

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Groundwater is the water present beneath Earth's surface in soil pore spaces and in the fractures of rock formations.

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Health Canada

Health Canada (Santé Canada) is the department of the government of Canada with responsibility for national public health.

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A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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JAMA (journal)

JAMA: The Journal of the American Medical Association is a peer-reviewed medical journal published 48 times a year by the American Medical Association.

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John Sumpter

John Philip Sumpter OBE is a distinguished professor of Brunel University, UK.

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Kepone, also known as chlordecone, is an organochlorine compound and a colourless solid.

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A landfill site (also known as a tip, dump, rubbish dump, garbage dump or dumping ground and historically as a midden) is a site for the disposal of waste materials by burial.

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Learning disability

Learning disability is a classification that includes several areas of functioning in which a person has difficulty learning in a typical manner, usually caused by an unknown factor or factors.

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Lena Ek

Lena Ek (born 16 January 1958 in Mönsterås, Kalmar County) is a Swedish politician who served as Minister for the Environment from 2011 to 2014.

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Los Angeles Times

The Los Angeles Times is a daily newspaper which has been published in Los Angeles, California since 1881.

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A lubricant is a substance, usually organic, introduced to reduce friction between surfaces in mutual contact, which ultimately reduces the heat generated when the surfaces move.

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Malaria is a mosquito-borne infectious disease affecting humans and other animals caused by parasitic protozoans (a group of single-celled microorganisms) belonging to the Plasmodium type.

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Microplastics are small pieces of plastic that pollute the environment.

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Monoculture is the agricultural practice of producing or growing a single crop, plant, or livestock species, variety, or breed in a field or farming system at a time.

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Mycoestrogens are estrogens produced by fungi.

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Natural Resources Defense Council

The Natural Resources Defense Council (NRDC) is a United States-based, non-profit international environmental advocacy group, with its headquarters in New York City and offices in Washington, D.C.; San Francisco; Los Angeles; New Delhi, India; Chicago; Bozeman, Montana; and Beijing, China.

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Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system.

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Nonsteroidal is a term which is used to describe a compound that is not a steroid.

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Nonylphenols, from the Latin nōnus (number 9) and phenol, are a family of closely related organic compounds composed of phenol bearing a 9 carbon-tail.

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Nordic Council

The Nordic Council is the official body for formal inter-parliamentary co-operation among the Nordic countries.

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Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Obesogens are foreign chemical compounds that disrupt normal development and balance of lipid metabolism, which in some cases, can lead to obesity.

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Off-label use

Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.

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Old Order Mennonite

Old Order Mennonites form a branch of the Mennonite tradition.

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An organochloride, organochlorine compound, chlorocarbon, or chlorinated hydrocarbon is an organic compound containing at least one covalently bonded atom of chlorine that has an effect on the chemical behavior of the molecule.

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Oxybenzone or benzophenone-3 (trade names Milestab 9, Eusolex 4360, Escalol 567, KAHSCREEN BZ-3) is an organic compound.

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Parabens are a class of widely used preservatives in cosmetic and pharmaceutical products.

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Perfluorooctanoic acid

Perfluorooctanoic acid (PFOA) (conjugate base perfluorooctanoate), also known as C8, is a synthetic perfluorinated carboxylic acid and fluorosurfactant.

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Persistent organic pollutant

Persistent organic pollutants (POPs) are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes.

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Pesticides are substances that are meant to control pests, including weeds.

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Phenol formaldehyde resin

Phenol formaldehyde resins (PF) or phenolic resins are synthetic polymers obtained by the reaction of phenol or substituted phenol with formaldehyde.

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In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of a hydroxyl group (—OH) bonded directly to an aromatic hydrocarbon group.

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Philippe Grandjean (professor)

Philippe Grandjean (born 1 March 1950) is a Danish scientist working in environmental medicine.

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Phthalates, or phthalate esters, are esters of phthalic acid.

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Phytoestrogens are plant-derived xenoestrogens (see estrogen) not generated within the endocrine system, but consumed by eating phytoestrogenic plants.

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Plastic is material consisting of any of a wide range of synthetic or semi-synthetic organic compounds that are malleable and so can be molded into solid objects.

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Plastics industry

The plastics industry manufactures polymer materials — commonly called plastics — and offers services in plastics important to a range of industries, including packaging, building and construction, electronics, aerospace, and transportation.

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Pollutant-induced abnormal behaviour

Pollutant-induced abnormal behaviour refers to the abnormal behaviour induced by pollutants.

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Polybrominated diphenyl ethers

Polybrominated diphenyl ethers or PBDEs, are organobromine compounds that are used as flame retardant.

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Polychlorinated biphenyl

A polychlorinated biphenyl (PCB) is an organic chlorine compound with the formula C12H10−xClx.

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Polychlorinated dibenzofurans

Polychlorinated dibenzofurans (PCDFs) are a family of organic compounds with one or several of the hydrogens in the dibenzofuran structure replaced by chlorines.

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Polycyclic aromatic hydrocarbon

Polycyclic aromatic hydrocarbons (PAHs, also polyaromatic hydrocarbons or polynuclear aromatic hydrocarbons) are hydrocarbons—organic compounds containing only carbon and hydrogen—that are composed of multiple aromatic rings (organic rings in which the electrons are delocalized).

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Precautionary principle

The precautionary principle (or precautionary approach) generally defines actions on issues considered to be uncertain, for instance applied in assessing risk management.

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Prostate cancer

Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.

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Puberty is the process of physical changes through which a child's body matures into an adult body capable of sexual reproduction.

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Pyrethrum was a genus of several Old World plants now classified as Chrysanthemum or Tanacetum (e.g., C. coccineum) which are cultivated as ornamentals for their showy flower heads.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Reproductive system

The reproductive system or genital system is a system of sex organs within an organism which work together for the purpose of sexual reproduction.

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Safe Drinking Water Act

The Safe Drinking Water Act (SDWA) is the principal federal law in the United States intended to ensure safe drinking water for the public.

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Science (journal)

Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.

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Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Sex ratio

The sex ratio is the ratio of males to females in a population.

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Sex steroid

Sex steroids, also known as gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate androgen or estrogen receptors.

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Stink! is a 2015 American documentary film directed by Jon J. Whelan.

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Stockholm Convention on Persistent Organic Pollutants

Stockholm Convention on Persistent Organic Pollutants is an international environmental treaty, signed in 2001 and effective from May 2004, that aims to eliminate or restrict the production and use of persistent organic pollutants (POPs).

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Sweden (Sverige), officially the Kingdom of Sweden (Swedish), is a Scandinavian country in Northern Europe.

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Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.

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A textile is a flexible material consisting of a network of natural or artificial fibres (yarn or thread).

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The dose makes the poison

"The dose makes the poison" (sola dosis facit venenum) is an adage intended to indicate a basic principle of toxicology.

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The New York Times

The New York Times (sometimes abbreviated as The NYT or The Times) is an American newspaper based in New York City with worldwide influence and readership.

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Theo Colborn

Theodora Emily Colborn(née Decker; March 28, 1927 – December 14, 2014) was Founder and President Emerita of The Endocrine Disruption Exchange (TEDX), based in Paonia, Colorado, and Professor Emerita of Zoology at the University of Florida, Gainesville.

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The thyroid gland, or simply the thyroid, is an endocrine gland in the neck, consisting of two lobes connected by an isthmus.

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Tin can

A tin can, tin (especially in British English, Australian English and Canadian English), steel can, steel packaging or a can, is a container for the distribution or storage of goods, composed of thin metal.

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Toxic Substances Control Act of 1976

The Toxic Substances Control Act (TSCA) is a United States law, passed by the United States Congress in 1976 and administered by the United States Environmental Protection Agency, that regulates the introduction of new or already existing chemicals.

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Transatlantic Trade and Investment Partnership

The Transatlantic Trade and Investment Partnership (TTIP) is a proposed trade agreement between the European Union and the United States, with the aim of promoting trade and multilateral economic growth.

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Tributyltin (TBT) is an umbrella term for a class of organotin compounds which contain the (C4H9)3Sn group, with a prominent example being tributyltin oxide.

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Typhoid fever

Typhoid fever, also known simply as typhoid, is a bacterial infection due to ''Salmonella'' typhi that causes symptoms.

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Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus and murine typhus.

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United Nations Environment Programme

The United Nations Environment Programme (UNEP) is an agency of United Nations and coordinates its environmental activities, assisting developing countries in implementing environmentally sound policies and practices.

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United States Congress

The United States Congress is the bicameral legislature of the Federal government of the United States.

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United States Environmental Protection Agency

The Environmental Protection Agency is an independent agency of the United States federal government for environmental protection.

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United States Office of Research Integrity

The Office of Research Integrity (ORI) is one of the bodies concerned with research integrity in the United States.

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Utrecht University

Utrecht University (UU; Universiteit Utrecht, formerly Rijksuniversiteit Utrecht) is a university in Utrecht, the Netherlands.

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Vaginal cancer

Vaginal cancer is a malignant tumor that forms in the tissues of the vagina.

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Vinclozolin (trade names Ronilan, Curalan, Vorlan, Touche) is a common dicarboximide fungicide used to control diseases, such as blights, rots and molds in vineyards, and on fruits and vegetables such as raspberries, lettuce, kiwi, snap beans, and onions.

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Virilization or masculinization is the biological development of sex differences, changes that make a male body different from a female body.

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Volatile organic compound

Volatile organic compounds (VOCs) are organic chemicals that have a high vapor pressure at ordinary room temperature.

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Whiteleg shrimp

Whiteleg shrimp (Litopenaeus vannamei, formerly Penaeus vannamei), also known as Pacific white shrimp or king prawn, is a variety of prawn of the eastern Pacific Ocean commonly caught or farmed for food.

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World Health Organization

The World Health Organization (WHO; French: Organisation mondiale de la santé) is a specialized agency of the United Nations that is concerned with international public health.

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World War II

World War II (often abbreviated to WWII or WW2), also known as the Second World War, was a global war that lasted from 1939 to 1945, although conflicts reflecting the ideological clash between what would become the Allied and Axis blocs began earlier.

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Xenoestrogens are a type of xenohormone that imitates estrogen.

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Xenohormones are a group of either naturally occurring or artificially created compounds showing hormone-like properties.

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Yushō disease

(literally oil symptoms) was a mass poisoning by polychlorinated biphenyls (PCBs) which occurred in northern Kyūshū, Japan in 1968.

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Zearalenone (ZEN), also known as RAL and F-2 mycotoxin, is a potent estrogenic metabolite produced by some Fusarium and Gibberella species.

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[1] https://en.wikipedia.org/wiki/Endocrine_disruptor

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