Epipregnanolone

Epipregnanolone, also known as 3β-hydroxy-5β-pregnan-20-one, 3β,5β-tetrahydroprogesterone, or 3β,5β-THP, is an endogenous neurosteroid. ^[1]

Allopregnanolone

Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. Epipregnanolone and Allopregnanolone are neurosteroids and pregnanes.

See Epipregnanolone and Allopregnanolone

Allosteric modulator

In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.

See Epipregnanolone and Allosteric modulator

Biosynthesis, i.e., chemical synthesis occuring in biological contexts, is a term most often referring to multi-step, enzyme-catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthesis) serve as enzyme substrates, with conversion by the living organism either into simpler or more complex products.

See Epipregnanolone and Biosynthesis

Channel opener

A channel opener, also known as a channel activator, is a type of drug which facilitates ion flow through ion channels.

See Epipregnanolone and Channel opener

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See Epipregnanolone and Endogeny (biology)

GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

See Epipregnanolone and GABAA receptor

Isopregnanolone

Isopregnanolone, also known as isoallopregnanolone and epiallopregnanolone, as well as sepranolone, and as 3β-hydroxy-5α-pregnan-20-one or 3β,5α-tetrahydroprogesterone (3β,5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone. Epipregnanolone and Isopregnanolone are GABAA receptor negative allosteric modulators, neurosteroids and pregnanes.

See Epipregnanolone and Isopregnanolone

Neurosteroid

Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Epipregnanolone and Neurosteroid are neurosteroids.

See Epipregnanolone and Neurosteroid

NMDA receptor

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons.

See Epipregnanolone and NMDA receptor

Pregnanolone

Pregnanolone, also known as eltanolone, is an endogenous inhibitory neurosteroid which is produced in the body from progesterone. Epipregnanolone and Pregnanolone are 5β-Pregnanes and neurosteroids.

See Epipregnanolone and Pregnanolone

Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. Epipregnanolone and Progesterone are neurosteroids and pregnanes.

See Epipregnanolone and Progesterone

Progestogen

Progestogens, also sometimes written progestins, progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR).

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Reaction intermediate

In chemistry, a reaction intermediate, or intermediate, is a molecular entity arising within the sequence of a stepwise chemical reaction.

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Sulfate

The sulfate or sulphate ion is a polyatomic anion with the empirical formula.

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TRPM3

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.

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3β-Androstanediol

3β-Androstanediol, also known as 5α-androstane-3β,17β-diol, and sometimes shortened in the literature to 3β-diol, is an endogenous steroid hormone and a metabolite of androgens like dehydroepiandrosterone (DHEA) and dihydrotestosterone (DHT).

See Epipregnanolone and 3β-Androstanediol

3β-Dihydroprogesterone

3β-Dihydroprogesterone (3β-DHP), also known as 3β-hydroxyprogesterone, or pregn-4-en-3β-ol-20-one (4-pregnenolone, δ4-pregnenolone), is an endogenous steroid. Epipregnanolone and 3β-Dihydroprogesterone are pregnanes.

See Epipregnanolone and 3β-Dihydroprogesterone

3β-Hydroxysteroid dehydrogenase

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland.

See Epipregnanolone and 3β-Hydroxysteroid dehydrogenase

5α-Dihydroprogesterone

5α-Dihydroprogesterone (5α-DHP, allopregnanedione, or 5α-pregnane-3,20-dione) is an endogenous progestogen and neurosteroid that is synthesized from progesterone. Epipregnanolone and 5α-Dihydroprogesterone are neurosteroids and pregnanes.

See Epipregnanolone and 5α-Dihydroprogesterone

5β-Dihydroprogesterone

5β-Dihydroprogesterone (5β-DHP, pregnanedione, or 5β-pregnane-3,20-dione) is an endogenous neurosteroid and an intermediate in the biosynthesis of pregnanolone and epipregnanolone from progesterone. Epipregnanolone and 5β-Dihydroprogesterone are 5β-Pregnanes and neurosteroids.

See Epipregnanolone and 5β-Dihydroprogesterone

5β-Reductase

5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.

See Epipregnanolone and 5β-Reductase

References

[1] https://en.wikipedia.org/wiki/Epipregnanolone

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