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Epoxide hydrolase

Index Epoxide hydrolase

Epoxide hydrolases (EH's), also known as epoxide hydratases, are enzymes that metabolize compounds that contain an epoxide residue; they convert this residue to two hydroxyl residues through a dihydroxylation reaction to form diol products. [1]

49 relations: Alpha/beta hydrolase superfamily, Aminopeptidase, C-terminus, Cell membrane, Cell signaling, Chemotaxis, Cholesterol-5,6-oxide hydrolase, Cis–trans isomerism, Coronaric acid, CpG site, Cytochrome P450, Cytoplasm, Cytosol, Dihydroxylation, Diol, Drug design, Endoplasmic reticulum, Enzyme, EPHX1, Epoxide, Epoxide hydrolase 2, Epoxide hydrolase 3, Epoxydocosapentaenoic acid, Epoxyeicosatetraenoic acid, Epoxyeicosatrienoic acid, Extracellular, Gene silencing, Genomic imprinting, Gleason grading system, Hepoxilin, Hepoxilin-epoxide hydrolase, Hydroxy group, In vivo, International Union of Pure and Applied Chemistry, Isozyme, Leiomyoma, Leukotriene A4, Leukotriene B4, Leukotriene-A4 hydrolase, Linoleic acid, Melanoma, Messenger RNA, MEST (gene), Microsomal epoxide hydrolase, Mycobacterium tuberculosis, Polyunsaturated fat, Vernolic acid, White blood cell, Xenobiotic.

Alpha/beta hydrolase superfamily

The alpha/beta hydrolase superfamily is superfamily of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function that share a common fold.

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Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides.

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The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.

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Cholesterol-5,6-oxide hydrolase

Cholesterol-5,6-oxide hydrolase (cholesterol-epoxide hydrolase, ChEH) is an enzyme with systematic name 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase.

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Cis–trans isomerism

Cis–trans isomerism, also known as geometric isomerism or configurational isomerism, is a term used in organic chemistry.

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Coronaric acid

Coronaric acid (isoleukotoxin) is a mono-unsaturated, epoxide derivative of the di-saturated fatty acid, linoleic acid (i.e. 9(Z),12(Z) octadecadienoic acid. It is a mixture of the two optically active isomers of 12(Z) 9,10-epoxy-octadecenoic acid. This mixture is also termed 9,10-epoxy-12Z-octadecenoic acid or 9(10)-EpOME and when formed by or studied in mammalians, isoleukotoxin.

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CpG site

The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction.

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Cytochrome P450

Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.

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In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Dihydroxylation is the process by which an alkene is converted into a vicinal diol.

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A diol or glycol is a chemical compound containing two hydroxyl groups (−OH groups).

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Drug design

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.

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Endoplasmic reticulum

The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.

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Enzymes are macromolecular biological catalysts.

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Epoxide hydrolase 1 is an enzyme encoded by the EPHX1 gene in humans.

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An epoxide is a cyclic ether with a three-atom ring.

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Epoxide hydrolase 2

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene.

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Epoxide hydrolase 3

Epoxide hydrolase 3 (ABHD9, EH3, EPHX3), encoded by the EPHX3 gene, is the third defined isozyme in a set of epoxide hydrolase isozymes, i.e. the epoxide hydrolases.

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Epoxydocosapentaenoic acid

Epoxide docosapentaenoic acids (epoxydocosapentaenoic acids, EDPs, or EpDPEs) are metabolites of the 22-carbon straight-chain omega-3 fatty acid, docosahexaenoic acid (DHA).

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Epoxyeicosatetraenoic acid

Epoxyeicosatetraenoic acids (EEQs or EpETEs) are a set of biologically active epoxides that various cell types make by metabolizing the omega 3 fatty acid, eicosapentaenoic acid (EPA), with certain cytochrome P450 epoxygenases.

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Epoxyeicosatrienoic acid

The epoxyeicosatrienoic acids or EETs are signaling molecules formed within various types of cells by the metabolism of arachidonic acid by a specific subset of Cytochrome P450 enzymes termed cytochrome P450 epoxygenases.

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In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".

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Gene silencing

Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene.

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Genomic imprinting

Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed in a parent-of-origin-specific manner.

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Gleason grading system

The Gleason grading system is used to help evaluate the prognosis of men with prostate cancer using samples from a prostate biopsy.

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Hepoxilins (Hx) are a set of epoxyalcohol metabolites of polyunsaturated fatty acids (PUFA), i.e. they possess both an epoxide and an alcohol (i.e. hydroxyl) residue.

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Hepoxilin-epoxide hydrolase

In enzymology, a hepoxilin-epoxide hydrolase is an enzyme that catalyzes the conversion of the epoxyalcohol metabolites arachidonic acid, hepoxilin A3 and hepoxilin B3 to their tri-hydroxyl products, trioxolin A3 and trioxilin B3, respectively.

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Hydroxy group

A hydroxy or hydroxyl group is the entity with the formula OH.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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International Union of Pure and Applied Chemistry

The International Union of Pure and Applied Chemistry (IUPAC) is an international federation of National Adhering Organizations that represents chemists in individual countries.

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Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.

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A leiomyoma, also known as fibroids, is a benign smooth muscle tumor that very rarely becomes cancer (0.1%).

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Leukotriene A4

Leukotriene A4 is a leukotriene.

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Leukotriene B4

Leukotriene B4 (LTB4) is a leukotriene involved in inflammation.

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Leukotriene-A4 hydrolase

Leukotriene A4 hydrolase, also known as LTA4H is a human gene.

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Linoleic acid

Linoleic acid (LA), a carboxylic acid, is a polyunsaturated omega-6 fatty acid, an 18-carbon chain with two double bonds in cis configuration.

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Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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MEST (gene)

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.

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Microsomal epoxide hydrolase

In enzymology, a microsomal epoxide hydrolase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are cis-stilbene oxide and H2O, whereas its product is (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.

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Mycobacterium tuberculosis

Mycobacterium tuberculosis is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis.

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Polyunsaturated fat

Polyunsaturated fats are fats in which the constituent hydrocarbon chain possesses two or more carbon–carbon double bonds.

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Vernolic acid

Vernolic acid (leukotoxin) is a long chain fatty acid that is monounsaturated and contains an epoxide.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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A xenobiotic is a chemical substance found within an organism that is not naturally produced or expected to be present within the organism.

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[1] https://en.wikipedia.org/wiki/Epoxide_hydrolase

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