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Epoxydocosapentaenoic acid

Index Epoxydocosapentaenoic acid

Epoxide docosapentaenoic acids (epoxydocosapentaenoic acids, EDPs, or EpDPEs) are metabolites of the 22-carbon straight-chain omega-3 fatty acid, docosahexaenoic acid (DHA). [1]

39 relations: Acylation, Angiogenesis, Arachidonic acid, Autocrine signalling, Beta oxidation, Cis–trans isomerism, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2S1, CYP4A11, CYP4F12, CYP4F8, Cytochrome P450, family 1, member A1, Diol, Docosahexaenoic acid, Double bond, Eicosapentaenoic acid, Enantiomer, Epoxide, Epoxide hydrolase 2, Epoxyeicosatetraenoic acid, Epoxyeicosatrienoic acid, Epoxygenase, Fish oil, Omega-3 fatty acid, Omega-6 fatty acid, Paracrine signalling, Phospholipase A2, Phospholipid, Polyunsaturated fatty acid, Protein isoform, Structural isomer, Vicinal (chemistry), 20-Hydroxyeicosatetraenoic acid.

Acylation

In chemistry, acylation (rarely, but more formally: alkanoylation) is the process of adding an acyl group to a compound.

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Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.

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Arachidonic acid

Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).

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Autocrine signalling

Autocrine signaling is a form of cell signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on that same cell, leading to changes in the cell.

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Beta oxidation

In biochemistry and metabolism, beta-oxidation is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citric acid cycle, and NADH and FADH2, which are co-enzymes used in the electron transport chain.

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Cis–trans isomerism

Cis–trans isomerism, also known as geometric isomerism or configurational isomerism, is a term used in organic chemistry.

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CYP1A2

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

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CYP2C18

Cytochrome P450 2C18 is a protein that in humans is encoded by the CYP2C18 gene.

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CYP2C19

Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.

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CYP2C8

Cytochrome P4502C8 (abbreviated CYP2C8), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

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CYP2C9

Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.

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CYP2E1

Cytochrome P450 2E1 (abbreviated CYP2E1) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body.

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CYP2J2

Cytochrome P450 2J2 (CYP2J2) is a protein that in humans is encoded by the CYP2J2 gene.

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CYP2S1

Cytochrome P450 2S1 is a protein that in humans is encoded by the CYP2S1 gene.

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CYP4A11

Cytochrome P450 4A11 is a protein that in humans is encoded by the CYP4A11 gene.

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CYP4F12

Cytochrome P450 4F12 is a protein that in humans is encoded by the CYP4F12 gene.

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CYP4F8

Cytochrome P450 4F8 is a protein that in humans is encoded by the CYP4F8 gene.

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Cytochrome P450, family 1, member A1

Cytochrome P450, family 1, subfamily A, polypeptide 1 is a protein that in humans is encoded by the CYP1A1 gene.

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Diol

A diol or glycol is a chemical compound containing two hydroxyl groups (−OH groups).

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Docosahexaenoic acid

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina.

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Double bond

A double bond in chemistry is a chemical bond between two chemical elements involving four bonding electrons instead of the usual two.

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Eicosapentaenoic acid

Eicosapentaenoic acid (EPA; also icosapentaenoic acid) is an omega-3 fatty acid.

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Enantiomer

In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).

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Epoxide

An epoxide is a cyclic ether with a three-atom ring.

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Epoxide hydrolase 2

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene.

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Epoxyeicosatetraenoic acid

Epoxyeicosatetraenoic acids (EEQs or EpETEs) are a set of biologically active epoxides that various cell types make by metabolizing the omega 3 fatty acid, eicosapentaenoic acid (EPA), with certain cytochrome P450 epoxygenases.

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Epoxyeicosatrienoic acid

The epoxyeicosatrienoic acids or EETs are signaling molecules formed within various types of cells by the metabolism of arachidonic acid by a specific subset of Cytochrome P450 enzymes termed cytochrome P450 epoxygenases.

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Epoxygenase

Epoxygenases are a set of membrane-bound, heme-containing cytochrome P450 (CYP P450 or just CYP) enzymes that metabolize polyunsaturated fatty acids to epoxide products that have a range of biological activities.

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Fish oil

Fish oil is oil derived from the tissues of oily fish.

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Omega-3 fatty acid

Omega−3 fatty acids, also called ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs).

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Omega-6 fatty acid

Omega-6 fatty acids (also referred to as ω-6 fatty acids or n-6 fatty acids) are a family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the ''n''-6 position, that is, the sixth bond, counting from the methyl end.

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Paracrine signalling

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.

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Phospholipase A2

Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.

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Phospholipid

Phospholipids are a class of lipids that are a major component of all cell membranes.

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Polyunsaturated fatty acid

Polyunsaturated fatty acids (PUFAs) are fatty acids that contain more than one double bond in their backbone.

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Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

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Structural isomer

Structural isomerism, or constitutional isomerism (per IUPAC), is a form of isomerism in which molecules with the same molecular formula have different bonding patterns and atomic organization, as opposed to stereoisomerism, in which molecular bonds are always in the same order and only spatial arrangement differs.

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Vicinal (chemistry)

In chemistry the descriptor vicinal (from Latin vicinus.

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20-Hydroxyeicosatetraenoic acid

20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pathway remodeling.

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References

[1] https://en.wikipedia.org/wiki/Epoxydocosapentaenoic_acid

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