Table of Contents
34 relations: Agonist, Anxiolytic, Azapirone, Befiradol, Behavioural despair test, Binding selectivity, Buspirone, Cmax (pharmacology), Conflict procedure, Cortisol, Depression (mood), Dizziness, Dose (biochemistry), F-15,599, Flesinoxan, Growth hormone, Half-life, Human, Imipramine, Intrinsic activity, Ipsapirone, Ligand (biochemistry), Oral administration, Paroxetine, Partial agonist, Potency (pharmacology), Preclinical development, Rapid eye movement sleep, Serotonin, Side effect, Somnolence, Tandospirone, Thermoregulation, 5-HT1A receptor.
- Azapirones
Agonist
An agonist is a chemical that activates a receptor to produce a biological response.
Anxiolytic
An anxiolytic (also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety.
Azapirone
Azapirones are a class of drugs used as anxiolytics, antidepressants, and antipsychotics. Eptapirone and Azapirone are azapirones.
Befiradol
Befiradol (F-13,640; NLX-112) is an experimental drug being studied for the treatment of levodopa-induced dyskinesia.
Behavioural despair test
The behavioural despair test (or Porsolt forced swimming test) is a test, centered on a rodent's response to the threat of drowning, whose result has been interpreted as measuring susceptibility to negative mood.
See Eptapirone and Behavioural despair test
Binding selectivity
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
See Eptapirone and Binding selectivity
Buspirone
Buspirone, sold under the brand name Buspar, among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder. Eptapirone and Buspirone are Aminopyrimidines and azapirones.
Cmax (pharmacology)
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose.
See Eptapirone and Cmax (pharmacology)
Conflict procedure
The conflict procedure is an experiment often used in scientific research to quantify anxiety levels by measuring changes in punished/unpunished responses.
See Eptapirone and Conflict procedure
Cortisol
Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone.
Depression (mood)
Depression is a mental state of low mood and aversion to activity.
See Eptapirone and Depression (mood)
Dizziness
Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness.
Dose (biochemistry)
A dose is a measured quantity of a medicine, nutrient, or pathogen which is delivered as a unit.
See Eptapirone and Dose (biochemistry)
F-15,599
F-15,599, also known as NLX-101, is a potent and selective 5-HT1A receptor full agonist.
Flesinoxan
Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class.
Growth hormone
Growth hormone (GH) or somatotropin, also known as human growth hormone (hGH or HGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals.
See Eptapirone and Growth hormone
Half-life
Half-life (symbol) is the time required for a quantity (of substance) to reduce to half of its initial value.
Human
Humans (Homo sapiens, meaning "thinking man") or modern humans are the most common and widespread species of primate, and the last surviving species of the genus Homo.
Imipramine
Imipramine, sold under the brand name Tofranil, among others, is a tricyclic antidepressant (TCA) mainly used in the treatment of depression.
Intrinsic activity
Intrinsic activity (IA) and efficacy refer to the relative ability of a drug-receptor complex to produce a maximum functional response.
See Eptapirone and Intrinsic activity
Ipsapirone
Ipsapirone is a selective 5-HT1A receptor partial agonist of the piperazine and azapirone chemical classes. Eptapirone and Ipsapirone are Aminopyrimidines, azapirones, Lactams and piperazines.
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See Eptapirone and Ligand (biochemistry)
Oral administration
| name.
See Eptapirone and Oral administration
Paroxetine
Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, post-traumatic stress disorder, generalized anxiety disorder, and premenstrual dysphoric disorder.
Partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
See Eptapirone and Partial agonist
Potency (pharmacology)
In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.
See Eptapirone and Potency (pharmacology)
Preclinical development
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.
See Eptapirone and Preclinical development
Rapid eye movement sleep
Rapid eye movement sleep (REM sleep or REMS) is a unique phase of sleep in mammals (including humans) and birds, characterized by random rapid movement of the eyes, accompanied by low muscle tone throughout the body, and the propensity of the sleeper to dream vividly.
See Eptapirone and Rapid eye movement sleep
Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
See Eptapirone and Side effect
Somnolence
Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
Tandospirone
Tandospirone, sold under the brand name Sediel, is an anxiolytic and antidepressant medication used in Japan and China, where it is marketed by Dainippon Sumitomo Pharma. Eptapirone and Tandospirone are Aminopyrimidines, azapirones and piperazines.
See Eptapirone and Tandospirone
Thermoregulation
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.
See Eptapirone and Thermoregulation
5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter.
See Eptapirone and 5-HT1A receptor
See also
Azapirones
- Alnespirone
- Azapirone
- Azaspirodecane
- Azaspirodecanedione
- Binospirone
- Buspirone
- Buspirone/testosterone
- Enilospirone
- Eptapirone
- Gepirone
- Ipsapirone
- Perospirone
- Revospirone
- Tandospirone
- Tiospirone
- Umespirone
- Zalospirone
References
Also known as C16H23N7O2, F 11,440, F 11440, F-11,440, F-11440, F11,440, F11440.