34 relations: Agonist, Anxiolytic, Azapirone, Befiradol, Behavioural despair test, Binding selectivity, Buspirone, Cmax (pharmacology), Conflict procedure, Cortisol, Depression (mood), Dizziness, Dose (biochemistry), F-15,599, Flesinoxan, Growth hormone, Half-life, Human, Imipramine, Intrinsic activity, Ipsapirone, Ligand (biochemistry), Oral administration, Paroxetine, Partial agonist, Potency (pharmacology), Pre-clinical development, Rapid eye movement sleep, Serotonin, Side effect, Somnolence, Tandospirone, Thermoregulation, 5-HT1A receptor.
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.
Azapirones are a class of drugs used as anxiolytics, antidepressants, and antipsychotics.
Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist.
The behavioural despair test (or Porsolt forced swimming test) is a test, centered on a rodent's response to the threat of drowning, whose result has been interpreted as measuring susceptibility to negative mood.
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
Buspirone, sold under the brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder (GAD).
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
The conflict procedure is an experiment often used in scientific research to quantify anxiety levels by measuring changes in punished/unpunished responding.
Cortisol is a steroid hormone, in the glucocorticoid class of hormones.
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.
Dizziness is an impairment in spatial perception and stability.
A dose is a measured quantity of a medicine, nutrient, or pathogen which is delivered as a unit.
F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT1A receptor full agonist.
Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class.
Growth hormone (GH), also known as somatotropin (or as human growth hormone in its human form), is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals.
Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.
Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.
Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.
Ipsapirone is a selective 5-HT1A receptor partial agonist of the piperazine and azapirone chemical classes.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
In drug development, preclinical development, also named preclinical studies and nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) can begin, and during which important feasibility, iterative testing and drug safety data are collected.
Rapid eye movement sleep (REM sleep, REMS) is a unique phase of sleep in mammals and birds, distinguishable by random/rapid movement of the eyes, accompanied with low muscle tone throughout the body, and the propensity of the sleeper to dream vividly.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
Tandospirone (brand name Sediel) is an anxiolytic and antidepressant drug used in China and Japan, where it is marketed by Dainippon Sumitomo Pharma.
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).