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Estradiol glucuronide

Index Estradiol glucuronide

Estradiol glucuronide, or estradiol 17β-D-glucuronide, is a conjugated metabolite of estradiol. [1]

Table of Contents

  1. 57 relations: ABC transporter, ABCC4, ABCG2, Absorption (pharmacology), Agonist, Aqueous solution, ATP-binding domain of ABC transporters, Bioconjugation, Biological half-life, Biotransformation, Breast, Catechol estrogen, Cell (biology), Cholestasis, Enzyme, Estradiol, Estradiol 3-glucuronide, Estradiol sulfate, Estriol glucuronide, Estriol sulfate, Estrogen, Estrogen conjugate, Estrogen receptor, Estrone, Estrone glucuronide, Estrone sulfate, Excretion, Exogeny, First pass effect, Gastrointestinal tract, Glucuronic acid, Glucuronosyltransferase, GPER, In vitro, Intravenous therapy, Kidney, Lipoidal estradiol, Liver, Mammary gland, Membrane estrogen receptor, Metabolite, Multidrug resistance-associated protein 2, Oral administration, Organo anion transporter family, Ovulation, Pharmacokinetics, Potency (pharmacology), Prostate, Route of administration, Solute carrier organic anion transporter family member 1A2, ... Expand index (7 more) »

  2. Glucuronide esters

ABC transporter

The ABC transporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the oldest gene families.

See Estradiol glucuronide and ABC transporter

ABCC4

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.

See Estradiol glucuronide and ABCC4

ABCG2

ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.

See Estradiol glucuronide and ABCG2

Absorption (pharmacology)

Absorption is the journey of a drug travelling from the site of administration to the site of action.

See Estradiol glucuronide and Absorption (pharmacology)

Agonist

An agonist is a chemical that activates a receptor to produce a biological response.

See Estradiol glucuronide and Agonist

Aqueous solution

An aqueous solution is a solution in which the solvent is water.

See Estradiol glucuronide and Aqueous solution

ATP-binding domain of ABC transporters

In molecular biology, ATP-binding domain of ABC transporters is a water-soluble domain of transmembrane ABC transporters.

See Estradiol glucuronide and ATP-binding domain of ABC transporters

Bioconjugation

Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule.

See Estradiol glucuronide and Bioconjugation

Biological half-life

Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.

See Estradiol glucuronide and Biological half-life

Biotransformation

Biotransformation is the biochemical modification of one chemical compound or a mixture of chemical compounds.

See Estradiol glucuronide and Biotransformation

Breast

The breast is one of two prominences located on the upper ventral region of the torso among humans and other primates.

See Estradiol glucuronide and Breast

Catechol estrogen

A catechol estrogen is a steroidal estrogen that contains catechol (1,2-dihydroxybenzene) within its structure. Estradiol glucuronide and catechol estrogen are Estranes, estrogens and human metabolites.

See Estradiol glucuronide and Catechol estrogen

Cell (biology)

The cell is the basic structural and functional unit of all forms of life.

See Estradiol glucuronide and Cell (biology)

Cholestasis

Cholestasis is a condition where the flow of bile from the liver to the duodenum is impaired.

See Estradiol glucuronide and Cholestasis

Enzyme

Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.

See Estradiol glucuronide and Enzyme

Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. Estradiol glucuronide and Estradiol are Estranes, estrogens and Hepatotoxins.

See Estradiol glucuronide and Estradiol

Estradiol 3-glucuronide

Estradiol 3-glucuronide (E2-3G), also known as 17β-estradiol 3-(β-D-glucuronide), is a naturally occurring and endogenous estrogen conjugate. Estradiol glucuronide and Estradiol 3-glucuronide are estradiol esters, estrogens, glucuronide esters and human metabolites.

See Estradiol glucuronide and Estradiol 3-glucuronide

Estradiol sulfate

Estradiol sulfate (E2S), or 17β-estradiol 3-sulfate, is a natural, endogenous steroid and an estrogen ester. Estradiol glucuronide and Estradiol sulfate are estradiol esters and human metabolites.

See Estradiol glucuronide and Estradiol sulfate

Estriol glucuronide

Estriol glucuronide (E3G), or oestriol glucuronide, also known as estriol monoglucuronide, as well as estriol 16α-β-D-glucosiduronic acid, is a natural, steroidal estrogen and the glucuronic acid (β-D-glucopyranuronic acid) conjugate of estriol. Estradiol glucuronide and estriol glucuronide are Estranes, estrogens, glucuronide esters and human metabolites.

See Estradiol glucuronide and Estriol glucuronide

Estriol sulfate

Estriol sulfate, or estriol 3-sulfate, is a conjugated metabolite of estriol that is present in high quantities during pregnancy. Estradiol glucuronide and estriol sulfate are estrogens and human metabolites.

See Estradiol glucuronide and Estriol sulfate

Estrogen

Estrogen (oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. Estradiol glucuronide and Estrogen are Estranes, estrogens and Hepatotoxins.

See Estradiol glucuronide and Estrogen

Estrogen conjugate

An estrogen conjugate is a conjugate of an endogenous estrogen. Estradiol glucuronide and estrogen conjugate are Estranes, estrogens and human metabolites.

See Estradiol glucuronide and Estrogen conjugate

Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

See Estradiol glucuronide and Estrogen receptor

Estrone

Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. Estradiol glucuronide and Estrone are Estranes and estrogens.

See Estradiol glucuronide and Estrone

Estrone glucuronide

Estrone glucuronide, or estrone-3-D-glucuronide, is a conjugated metabolite of estrone. Estradiol glucuronide and estrone glucuronide are Estranes, estrogens, glucuronide esters and human metabolites.

See Estradiol glucuronide and Estrone glucuronide

Estrone sulfate

Estrone sulfate, also known as E1S, E1SO4 and estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate. Estradiol glucuronide and estrone sulfate are estrogens and human metabolites.

See Estradiol glucuronide and Estrone sulfate

Excretion

Excretion is elimination of metabolic waste, which is an essential process in all organisms.

See Estradiol glucuronide and Excretion

Exogeny

In a variety of contexts, exogeny or exogeneity is the fact of an action or object originating externally.

See Estradiol glucuronide and Exogeny

First pass effect

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.

See Estradiol glucuronide and First pass effect

Gastrointestinal tract

The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.

See Estradiol glucuronide and Gastrointestinal tract

Glucuronic acid

Glucuronic acid (from Greek γλεῦκος "sweet wine, must" and οá½–ρον "urine") is a uronic acid that was first isolated from urine (hence the name "uronic acid").

See Estradiol glucuronide and Glucuronic acid

Glucuronosyltransferase

Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule.

See Estradiol glucuronide and Glucuronosyltransferase

GPER

G protein-coupled estrogen receptor 1 (GPER), also known as G protein-coupled receptor 30 (GPR30), is a protein that in humans is encoded by the GPER gene.

See Estradiol glucuronide and GPER

In vitro

In vitro (meaning in glass, or in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

See Estradiol glucuronide and In vitro

Intravenous therapy

Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.

See Estradiol glucuronide and Intravenous therapy

Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation.

See Estradiol glucuronide and Kidney

Lipoidal estradiol

Lipoidal estradiol (LE2) is the variety of endogenous C17β long-chain fatty acid esters of estradiol which are formed as metabolites of estradiol. Estradiol glucuronide and Lipoidal estradiol are estradiol esters, Estranes, estrogens and human metabolites.

See Estradiol glucuronide and Lipoidal estradiol

Liver

The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.

See Estradiol glucuronide and Liver

Mammary gland

A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring.

See Estradiol glucuronide and Mammary gland

Membrane estrogen receptor

Membrane estrogen receptors (mERs) are a group of receptors which bind estrogen.

See Estradiol glucuronide and Membrane estrogen receptor

Metabolite

In biochemistry, a metabolite is an intermediate or end product of metabolism.

See Estradiol glucuronide and Metabolite

Multidrug resistance-associated protein 2

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.

See Estradiol glucuronide and Multidrug resistance-associated protein 2

Oral administration

| name.

See Estradiol glucuronide and Oral administration

Organo anion transporter family

Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane.

See Estradiol glucuronide and Organo anion transporter family

Ovulation

Ovulation is the release of eggs from the ovaries.

See Estradiol glucuronide and Ovulation

Pharmacokinetics

Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration.

See Estradiol glucuronide and Pharmacokinetics

Potency (pharmacology)

In pharmacology, potency or biological potency is a measure of a drug's biological activity expressed in terms of the dose required to produce a pharmacological effect of given intensity.

See Estradiol glucuronide and Potency (pharmacology)

Prostate

The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation.

See Estradiol glucuronide and Prostate

Route of administration

In pharmacology and toxicology, a route of administration is the way by which a drug, fluid, poison, or other substance is taken into the body.

See Estradiol glucuronide and Route of administration

Solute carrier organic anion transporter family member 1A2

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.

See Estradiol glucuronide and Solute carrier organic anion transporter family member 1A2

Solute carrier organic anion transporter family member 1B1

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.

See Estradiol glucuronide and Solute carrier organic anion transporter family member 1B1

Solute carrier organic anion transporter family member 1B3

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

See Estradiol glucuronide and Solute carrier organic anion transporter family member 1B3

Solute carrier organic anion transporter family member 3A1

Solute carrier organic anion transporter family member 3A1 is a protein that in humans is encoded by the SLCO3A1 gene.

See Estradiol glucuronide and Solute carrier organic anion transporter family member 3A1

Structural isomer

In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a compound is another compound whose molecule has the same number of atoms of each element, but with logically distinct bonds between them.

See Estradiol glucuronide and Structural isomer

Testicle

A testicle or testis (testes) is the male gonad in all bilaterians, including humans.

See Estradiol glucuronide and Testicle

Tissue (biology)

In biology, tissue is an assembly of similar cells and their extracellular matrix from the same embryonic origin that together carry out a specific function.

See Estradiol glucuronide and Tissue (biology)

Urine

Urine is a liquid by-product of metabolism in humans and in many other animals.

See Estradiol glucuronide and Urine

See also

Glucuronide esters

References

[1] https://en.wikipedia.org/wiki/Estradiol_glucuronide

Also known as E2-17G, Estradiol 17-D-glucuronide, Estradiol 17-glucuronide, Estradiol 17β-D-glucuronide, Estradiol 17β-glucuronide.

, Solute carrier organic anion transporter family member 1B1, Solute carrier organic anion transporter family member 1B3, Solute carrier organic anion transporter family member 3A1, Structural isomer, Testicle, Tissue (biology), Urine.