35 relations: Antiestrogen, Biotransformation, Bond cleavage, Clinical trial, EC508, Endometriosis, Endometrium, Enzyme, Enzyme inhibitor, Ester, Estradiol, Estrogen, Estrogen receptor, Estrone sulfamate, Estrone sulfate, First pass effect, Hormone replacement therapy, Hydrolysis, In vitro, Ligand (biochemistry), Liver, Menopause, Oral administration, Organic compound, Potency (pharmacology), Prodrug, Route of administration, Steroid, Steroid sulfatase, Sulfamic acid, Sulfate, Sulfonamide, Tissue selectivity, Transdermal, 17β-Hydroxysteroid dehydrogenase.
Antiestrogens, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like estradiol from mediating their biological effects in the body.
Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound.
Bond cleavage, or scission, is the splitting of chemical bonds.
Clinical trials are experiments or observations done in clinical research.
EC508, also known as estradiol 17β-(1-(4-(aminosulfonyl)benzoyl)--proline), is an estrogen which is under development by Evestra for use in menopausal hormone therapy and as a hormonal contraceptive for the prevention of pregnancy in women.
Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the inside of the uterus, grows outside of it.
The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus.
Enzymes are macromolecular biological catalysts.
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
Estrogen, or oestrogen, is the primary female sex hormone.
Estrogen receptors (ERs) are a group of proteins found inside cells.
Estrone sulfamate (EMATE), or estrone-3-O-sulfamate, is a highly potent, irreversible inhibitor of steroid sulfatase (STS) with additional estrogenic activity which is used in scientific research.
Estrone sulfate (E1S), or estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate.
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
Hormone replacement therapy (HRT) is any form of hormone therapy wherein the patient, in the course of medical treatment, receives hormones, either to supplement a lack of naturally occurring hormones or to substitute other hormones for naturally occurring hormones.
Hydrolysis is a term used for both an electro-chemical process and a biological one.
In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.
In chemistry, an organic compound is generally any chemical compound that contains carbon.
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body.
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids.
Sulfamic acid, also known as amidosulfonic acid, amidosulfuric acid, aminosulfonic acid, and sulfamidic acid, is a molecular compound with the formula H3NSO3.
The sulfate or sulphate (see spelling differences) ion is a polyatomic anion with the empirical formula.
In chemistry, the sulfonamide functional group (also spelled sulphonamide) is -S(.
Tissue selectivity is a topic in distribution (pharmacology) and a property of some drugs.
Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution.
17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.