13 relations: Afimoxifene, Bisphenol A, Diethylstilbestrol, Dissociation constant, Endocrine disruptor, Estrogen receptor, Gene, Inverse agonist, Nuclear receptor, Orphan receptor, Placenta, Selective estrogen receptor modulator, Steroid hormone receptor.
Afimoxifene, also known as 4-hydroxytamoxifen (4-OHT, 4-HT, OHTAM, others), is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and the major active metabolite of tamoxifen.
Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups.
Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is an estrogen medication which is mostly no longer used.
In chemistry, biochemistry, and pharmacology, a dissociation constant (K_d) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions.
Endocrine disruptors are chemicals that can interfere with endocrine (or hormone) systems at certain doses.
Estrogen receptors (ERs) are a group of proteins found inside cells.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
In biochemistry, an orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified.
The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.
Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).
Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.