76 relations: Aciclovir, Acute myeloid leukemia, Adenoviridae, Adverse effect, Alternating electric field therapy, Alternative medicine, American Cancer Society, Anaerobic organism, Apoptosis, Aurora B kinase, BI811283, Bladder cancer, Boehringer Ingelheim, Breast milk, Cancer, Carbon nanotube, Carlos Cordon-Cardo, Cell (biology), Chemotherapy, Clinical trial, Clostridium novyi, Clostridium sporogenes, Colloidal gold, Denaturation (biochemistry), Dichloroacetic acid, Drug development, Efficacy, Electric field, Enzyme, Enzyme inhibitor, Epigenetics, Ferrofluid, Geron Corporation, Glioma, Heat shock protein, High-intensity focused ultrasound, Histone, Hyperthermia therapy, Hypoxia (medical), Immunotherapy, Induction heating, Insulin potentiation therapy, Lytic cycle, Magnetic nanoparticles, Magnetic resonance imaging, Medication, Microwave, Model organism, National Center for Complementary and Integrative Health, Necrosis, ..., Neoplasm, Nutlin, Optimism bias, P53, Papilloma, Photodynamic therapy, Phytic acid, Placebo, Pre-clinical development, Prodrug, Protein, Quackwatch, Quercetin, Radiation therapy, Randomized controlled trial, Randy Jirtle, Small molecule, Surgery, Telomerase, Therapeutic index, Thymidine kinase, Tissue (biology), Topical medication, Tumor suppressor, Ultrasound, Verteporfin. Expand index (26 more) » « Shrink index
Aciclovir (ACV), also known as acyclovir, is an antiviral medication.
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery.
Alternating electric field therapy, sometimes called tumor treating fields (TTF or TTFields), is a type of electromagnetic field therapy using low-intensity electrical fields to treat cancer.
Alternative medicine, fringe medicine, pseudomedicine or simply questionable medicine is the use and promotion of practices which are unproven, disproven, impossible to prove, or excessively harmful in relation to their effect — in the attempt to achieve the healing effects of medicine.--> --> --> They differ from experimental medicine in that the latter employs responsible investigation, and accepts results that show it to be ineffective. The scientific consensus is that alternative therapies either do not, or cannot, work. In some cases laws of nature are violated by their basic claims; in some the treatment is so much worse that its use is unethical. Alternative practices, products, and therapies range from only ineffective to having known harmful and toxic effects.--> Alternative therapies may be credited for perceived improvement through placebo effects, decreased use or effect of medical treatment (and therefore either decreased side effects; or nocebo effects towards standard treatment),--> or the natural course of the condition or disease. Alternative treatment is not the same as experimental treatment or traditional medicine, although both can be misused in ways that are alternative. Alternative or complementary medicine is dangerous because it may discourage people from getting the best possible treatment, and may lead to a false understanding of the body and of science.-->---> Alternative medicine is used by a significant number of people, though its popularity is often overstated.--> Large amounts of funding go to testing alternative medicine, with more than US$2.5 billion spent by the United States government alone.--> Almost none show any effect beyond that of false treatment,--> and most studies showing any effect have been statistical flukes. Alternative medicine is a highly profitable industry, with a strong lobby. This fact is often overlooked by media or intentionally kept hidden, with alternative practice being portrayed positively when compared to "big pharma". --> The lobby has successfully pushed for alternative therapies to be subject to far less regulation than conventional medicine.--> Alternative therapies may even be allowed to promote use when there is demonstrably no effect, only a tradition of use. Regulation and licensing of alternative medicine and health care providers varies between and within countries. Despite laws making it illegal to market or promote alternative therapies for use in cancer treatment, many practitioners promote them.--> Alternative medicine is criticized for taking advantage of the weakest members of society.--! Terminology has shifted over time, reflecting the preferred branding of practitioners.. Science Based Medicine--> For example, the United States National Institutes of Health department studying alternative medicine, currently named National Center for Complementary and Integrative Health, was established as the Office of Alternative Medicine and was renamed the National Center for Complementary and Alternative Medicine before obtaining its current name. Therapies are often framed as "natural" or "holistic", in apparent opposition to conventional medicine which is "artificial" and "narrow in scope", statements which are intentionally misleading. --> When used together with functional medical treatment, alternative therapies do not "complement" (improve the effect of, or mitigate the side effects of) treatment.--> Significant drug interactions caused by alternative therapies may instead negatively impact functional treatment, making it less effective, notably in cancer.--> Alternative diagnoses and treatments are not part of medicine, or of science-based curricula in medical schools, nor are they used in any practice based on scientific knowledge or experience.--> Alternative therapies are often based on religious belief, tradition, superstition, belief in supernatural energies, pseudoscience, errors in reasoning, propaganda, fraud, or lies.--> Alternative medicine is based on misleading statements, quackery, pseudoscience, antiscience, fraud, and poor scientific methodology. Promoting alternative medicine has been called dangerous and unethical.--> Testing alternative medicine that has no scientific basis has been called a waste of scarce research resources.--> Critics state that "there is really no such thing as alternative medicine, just medicine that works and medicine that doesn't",--> that the very idea of "alternative" treatments is paradoxical, as any treatment proven to work is by definition "medicine".-->.
The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer.
An anaerobic organism or anaerobe is any organism that does not require oxygen for growth.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
Aurora B kinase is a protein that functions in the attachment of the mitotic spindle to the centromere.
BI 811283 is a small molecule inhibitor of the Aurora B kinase protein being developed by Boehringer Ingelheim for use as an anti-cancer agent.
Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder.
C.H. Boehringer Sohn AG & Ko.
Breast milk is the milk produced by the breasts (or mammary glands) of a human female to feed a child.
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
Carbon nanotubes (CNTs) are allotropes of carbon with a cylindrical nanostructure.
Carlos Cordon-Cardo (born 1957) is a Spanish-born American physician and scientist known for his research in experimental pathology and molecular oncology.
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
Clinical trials are experiments or observations done in clinical research.
Clostridium novyi (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class clostridia.
Clostridium sporogenes is a species of Gram-positive bacteria that belongs to the genus Clostridium.
Colloidal gold is a sol or colloidal suspension of nanoparticles of gold in a fluid, usually water.
Denaturation is a process in which proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure which is present in their native state, by application of some external stress or compound such as a strong acid or base, a concentrated inorganic salt, an organic solvent (e.g., alcohol or chloroform), radiation or heat.
Dichloroacetic acid (DCA), sometimes called bichloroacetic acid (BCA), is the chemical compound with formula.
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.
Efficacy is the ability to get a job done satisfactorily.
An electric field is a vector field surrounding an electric charge that exerts force on other charges, attracting or repelling them.
Enzymes are macromolecular biological catalysts.
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
A ferrofluid (portmanteau of ferromagnetic and fluid) is a liquid that becomes strongly magnetized in the presence of a magnetic field.
Geron Corporation is a biotechnology company located in Menlo Park, California, which specializes in developing and commercializing therapeutic products for cancer that inhibit telomerase.
A glioma is a type of tumor that starts in the glial cells of the brain or the spine.
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.
High intensity focused ultrasound (HIFU) is an early stage medical technology that is in various stages of development worldwide to treat a range of disorders.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes.
Hyperthermia therapy is a type of medical treatment in which body tissue is exposed to higher temperatures in an effort to treat cancer.
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.
Immunotherapy is the "treatment of disease by inducing, enhancing, or suppressing an immune response".
Induction heating is the process of heating an electrically conducting object (usually a metal) by electromagnetic induction, through heat generated in the object by eddy currents.
Insulin potentiation therapy (IPT) is an unproven alternative cancer treatment using insulin as an adjunct to low-dose chemotherapy.
The lytic cycle is one of the two cycles of viral reproduction (referring to bacterial viruses or bacteriophages), the other being the lysogenic cycle.
Magnetic nanoparticles are a class of nanoparticle that can be manipulated using magnetic fields.
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body in both health and disease.
A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
Microwaves are a form of electromagnetic radiation with wavelengths ranging from one meter to one millimeter; with frequencies between and.
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.
The National Center for Complementary and Integrative Health (NCCIH) is a United States government agency which explores complementary and alternative medicine (CAM).
Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.
Neoplasia is a type of abnormal and excessive growth of tissue.
Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumor suppressor p53, and which were discovered by screening a chemical library by Vassilev et al. Nutlin-1, nutlin-2, and nutlin-3 were all identified in the same screen; however, Nutlin-3 is the compound most commonly used in anti-cancer studies.
Optimism bias (also known as unrealistic or comparative optimism) is a cognitive bias that causes a person to believe that they are at a lesser risk of experiencing a negative event compared to others.
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
A papilloma (plural papillomas or papillomata) (papillo- + -oma) is a benign epithelial tumor growing exophytically (outwardly projecting) in nipple-like and often finger-like fronds.
Photodynamic therapy (PDT), sometimes called photochemotherapy, is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity).
Phytic acid (known as inositol hexakisphosphate (IP6), inositol polyphosphate, or phytate when in salt form), discovered in 1903, a saturated cyclic acid, is the principal storage form of phosphorus in many plant tissues, especially bran and seeds.
A placebo is a substance or treatment of no intended therapeutic value.
In drug development, preclinical development, also named preclinical studies and nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) can begin, and during which important feasibility, iterative testing and drug safety data are collected.
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
Quackwatch is a United States-based network of people founded by Stephen Barrett, which aims to "combat health-related frauds, myths, fads, fallacies, and misconduct" and to focus on "quackery-related information that is difficult or impossible to get elsewhere".
Quercetin, a plant flavonol from the flavonoid group of polyphenols, is found in many fruits, vegetables, leaves, and grains; red onions and kale are common foods containing appreciable content of quercetin.
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator.
A randomized controlled trial (or randomized control trial; RCT) is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment.
Randy Jirtle (born November 9, 1947) is an American biologist noted for his pioneering research in epigenetics, the branch of biology that deals with inherited information that does not reside in the nucleotide sequence of DNA.
Within the fields of molecular biology and pharmacology, a small molecule is a low molecular weight (< 900 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.
Surgery (from the χειρουργική cheirourgikē (composed of χείρ, "hand", and ἔργον, "work"), via chirurgiae, meaning "hand work") is a medical specialty that uses operative manual and instrumental techniques on a patient to investigate or treat a pathological condition such as a disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas.
Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres.
The therapeutic index (TI; also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity.
Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 18.104.22.168.
In biology, tissue is a cellular organizational level between cells and a complete organ.
A topical medication is a medication that is applied to a particular place on or in the body.
A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.
Ultrasound is sound waves with frequencies higher than the upper audible limit of human hearing.
Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration.