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14 relations: Arachidonic acid, COX-2 inhibitor, Cyclooxygenase, Docosahexaenoic acid, Eicosapentaenoic acid, Essential fatty acid, Free Radical Biology and Medicine, Inflammation, Lipid peroxidation, Neuroprostanes, Nonclassic eicosanoid, Oxidative stress, Pain, Prostaglandin.
Arachidonic acid
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
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COX-2 inhibitor
Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain.
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Cyclooxygenase
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid.
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Docosahexaenoic acid
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina.
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Eicosapentaenoic acid
Eicosapentaenoic acid (EPA; also icosapentaenoic acid) is an omega-3 fatty acid.
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Essential fatty acid
Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health but cannot synthesize them.
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Free Radical Biology and Medicine
Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Free Radical Biology and Medicine.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Lipid peroxidation
Lipid peroxidation is the oxidative degradation of lipids.
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Neuroprostanes
The neuroprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily docosahexaenoic acid) without the direct action of cyclooxygenase (COX) enzymes.
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Nonclassic eicosanoid
Nonclassic eicosanoids are biologically active signaling molecules made by oxygenation of twenty-carbon fatty acids other than the classic eicosanoids.
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Oxidative stress
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
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Pain
Pain is a distressing feeling often caused by intense or damaging stimuli.
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Prostaglandin
The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.
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