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FNDC5

Index FNDC5

Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. [1]

24 relations: Adipocyte, Amino acid, Ancient Greece, Brown adipose tissue, C-terminus, Epidermal growth factor, Fibronectin type III domain, Gene, Gene expression, Glycosylation, GW501516, Iris (mythology), Membrane protein, Messenger RNA, Myokine, N-terminus, Peptide hormone, Peroxisome, PPARGC1A, Protein, Start codon, TGF alpha, Thermogenin, White adipose tissue.

Adipocyte

Adipocytes, also known as lipocytes and fat cells, are the cells that primarily compose adipose tissue, specialized in storing energy as fat.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Ancient Greece

Ancient Greece was a civilization belonging to a period of Greek history from the Greek Dark Ages of the 13th–9th centuries BC to the end of antiquity (AD 600).

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Brown adipose tissue

Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat).

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Epidermal growth factor

Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR.

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Fibronectin type III domain

The Fibronectin type III domain is an evolutionary conserved protein domain that is widely found in animal proteins.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

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Glycosylation

Glycosylation (see also chemical glycosylation) is the reaction in which a carbohydrate, i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor).

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GW501516

GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.

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Iris (mythology)

In Greek mythology, Iris (Ἶρις) is the personification of the rainbow and messenger of the gods.

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Membrane protein

Membrane proteins are proteins that interact with, or are part of, biological membranes.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Myokine

A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Peptide hormone

Peptide hormones or protein hormones are hormones whose molecules are peptides or proteins, respectively.

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Peroxisome

A peroxisome is a type of organelle known as a microbody, found in virtually all eukaryotic cells.

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PPARGC1A

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Start codon

The start codon is the first codon of a messenger RNA (mRNA) transcript translated by a ribosome.

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TGF alpha

Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene.

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Thermogenin

Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is an uncoupling protein found in the mitochondria of brown adipose tissue (BAT).

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White adipose tissue

White adipose tissue (WAT) or white fat is one of the two types of adipose tissue found in mammals.

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References

[1] https://en.wikipedia.org/wiki/FNDC5

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