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Factor V Leiden

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Factor V Leiden (rs6025) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting (hypercoagulability). [1]

54 relations: Allele, Amino acid, Anticoagulant, Arginine, Clinical Chemistry and Laboratory Medicine, Cofactor (biochemistry), Deep vein thrombosis, Dilute Russell's viper venom time, Disease, Dominance (genetics), Enzyme, Estrogen, Exon, Factor V, Factor X, Fibrin, Fibrinogen, Gel electrophoresis of nucleic acids, Gene, Glutamine, Heart, Hematology, Heredity, Hormonal contraception, Leiden, Lung, Miscarriage, Missense mutation, Mutation, Myocardial infarction, Partial thromboplastin time, Penetrance, PharmGKB, Polymerase chain reaction, Pre-eclampsia, Pregnancy, Protein, Protein C, Prothrombin G20210A, Pulmonary circulation, Pulmonary embolism, Restriction enzyme, Single-nucleotide polymorphism, Stillbirth, Stroke, Surgery, Thrombin, Thrombophilia, Thrombus, Tobacco smoking, ..., Transient ischemic attack, Vein, Warfarin, Zygosity. Expand index (4 more) »

Allele

An allele is a variant form of a given gene.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Anticoagulant

Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.

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Arginine

Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.

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Christmas

Christmas is an annual festival commemorating the birth of Jesus Christ,Martindale, Cyril Charles.

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Christmas and holiday season

The Christmas season, also called the festive season, or the holiday season (mainly in the U.S. and Canada; often simply called the holidays),, is an annually recurring period recognized in many Western and Western-influenced countries that is generally considered to run from late November to early January.

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Christmas Eve

Christmas Eve is the evening or entire day before Christmas Day, the festival commemorating the birth of Jesus.

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Christmas traditions

Christmas traditions vary from country to country.

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Clinical Chemistry and Laboratory Medicine

Clinical Chemistry and Laboratory Medicine is a monthly peer-reviewed scientific journal that is published by De Gruyter.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Deep vein thrombosis

Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly the legs.

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Dilute Russell's viper venom time

Dilute Russell's viper venom time (dRVVT) is a laboratory test often used for detection of lupus anticoagulant (LA).

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Disease

A disease is any condition which results in the disorder of a structure or function in an organism that is not due to any external injury.

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Dominance (genetics)

Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Estrogen

Estrogen, or oestrogen, is the primary female sex hormone.

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Exon

An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

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Factor V

Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor.

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Factor X

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade.

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Fibrin

Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.

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Fibrinogen

Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood.

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Gel electrophoresis of nucleic acids

Nucleic acid electrophoresis is an analytical technique used to separate DNA or RNA fragments by size and reactivity.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Glutamine

Glutamine (symbol Gln or Q) is an α-amino acid that is used in the biosynthesis of proteins.

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Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

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Hematology

Hematology, also spelled haematology, is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood.

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Heredity

Heredity is the passing on of traits from parents to their offspring, either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents.

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Hormonal contraception

Hormonal contraception refers to birth control methods that act on the endocrine system.

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Leiden

Leiden (in English and archaic Dutch also Leyden) is a city and municipality in the province of South Holland, Netherlands.

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Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

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Miscarriage

Miscarriage, also known as spontaneous abortion and pregnancy loss, is the natural death of an embryo or fetus before it is able to survive independently.

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Missense mutation

In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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New Year

New Year is the time or day at which a new calendar year begins and the calendar's year count increments by one.

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New Year's Day

New Year's Day, also called simply New Year's or New Year, is observed on January 1, the first day of the year on the modern Gregorian calendar as well as the Julian calendar.

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New Year's Eve

In the Gregorian calendar, New Year's Eve (also known as Old Year's Day or Saint Sylvester's Day in many countries), the last day of the year, is on 31 December which is the seventh day of Christmastide.

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Partial thromboplastin time

The partial thromboplastin time (PTT) or activated partial thromboplastin time (aPTT or APTT) is a medical test that characterizes blood coagulation, also known as clotting.

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Penetrance

Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype).

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PharmGKB

The Pharmacogenomics Knowledgebase (PharmGKB) is a publicly available, online knowledgebase responsible for the aggregation, curation, integration and dissemination of knowledge regarding the impact of human genetic variation on drug response.

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Polymerase chain reaction

Polymerase chain reaction (PCR) is a technique used in molecular biology to amplify a single copy or a few copies of a segment of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.

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Pre-eclampsia

Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine.

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Pregnancy

Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein C

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals.

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Prothrombin G20210A

Prothrombin G20210A is a genetic condition that increases the risk of blood clots including deep vein thrombosis and pulmonary embolism.

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Pulmonary circulation

The pulmonary circulation is the portion of the circulatory system which carries deoxygenated blood away from the right ventricle of the heart, to the lungs, and returns oxygenated blood to the left atrium and ventricle of the heart.

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Pulmonary embolism

Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism).

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Restriction enzyme

A restriction enzyme or restriction endonuclease is an enzyme that cleaves DNA into fragments at or near specific recognition sites within the molecule known as restriction sites.

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Single-nucleotide polymorphism

A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

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Stillbirth

Stillbirth is typically defined as fetal death at or after 20 to 28 weeks of pregnancy.

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Stroke

A stroke is a medical condition in which poor blood flow to the brain results in cell death.

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Surgery

Surgery (from the χειρουργική cheirourgikē (composed of χείρ, "hand", and ἔργον, "work"), via chirurgiae, meaning "hand work") is a medical specialty that uses operative manual and instrumental techniques on a patient to investigate or treat a pathological condition such as a disease or injury, to help improve bodily function or appearance or to repair unwanted ruptured areas.

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Thrombin

Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.

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Thrombophilia

Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).

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Thrombus

A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.

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Tobacco smoking

Tobacco smoking is the practice of smoking tobacco and inhaling tobacco smoke (consisting of particle and gaseous phases).

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Transient ischemic attack

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by loss of blood flow (ischemia) in the brain, spinal cord, or retina, without tissue death (infarction).

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Vein

Veins are blood vessels that carry blood toward the heart.

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Warfarin

Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner).

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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2018

2018 has been designated as the third International Year of the Reef by the International Coral Reef Initiative.

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2019

2019 (MMXIX) will be a common year starting on Tuesday of the Gregorian calendar, the 2019th year of the Common Era (CE) and Anno Domini (AD) designations, the 19th year of the 3rd millennium, the 19th year of the 21st century, and the 10th and last year of the 2010s decade.

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Redirects here:

APC resistance, Leiden type, Arg506Gln, Factor 5 Leiden, Factor V G1691A, Factor V Leiden mutation, Factor V Leiden thrombophilia, Factor v leiden, R506Q, Rs6025.

References

[1] https://en.wikipedia.org/wiki/Factor_V_Leiden

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