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53 relations: Activation-induced cell death, Antibody, Apoptosis, Autoimmune lymphoproliferative syndrome, Bcl-2, Bcl-2 homologous antagonist killer, Bcl-2-associated X protein, Bcl-xL, BH3 interacting-domain death agonist, Cancer, Carcinogenesis, Caspase 8, Chemotherapy, Chromosome 10, Cornea, Cysteine, Cytochrome c, Cytotoxic T cell, Death domain, Death effector domain, Death-inducing signaling complex, Decoy receptor 3, Diablo homolog, Eugene C. Butcher, Ezrin, FADD, FAF1, Fas receptor, FNBP1, FYN, GRB2, Haplotype, Homeostasis, Homotrimer, Immune privilege, Immune response, Immune system, Inhibitor of apoptosis, Lupus erythematosus, Lymphadenopathy, Lymphocyte, Matrix metalloproteinase, PACSIN2, Perforin, Protein isoform, Protein–protein interaction, Signal transduction, Splenomegaly, T cell, Testicle, ..., Transmembrane protein, Tumor necrosis factor superfamily, Vascular endothelial growth inhibitor. Expand index (3 more) »
Activation-induced cell death
AICD (activation-induced cell death) is programmed cell death caused by the interaction of Fas receptors (Fas, CD95) and Fas ligands (FasL, CD95 ligand).
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Autoimmune lymphoproliferative syndrome
Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome,Straus SE, Jaffe ES, Puck JM et al.
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Bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.
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Bcl-2 homologous antagonist killer
Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene on chromosome 6.
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Bcl-2-associated X protein
Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene.
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Bcl-xL
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria.
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BH3 interacting-domain death agonist
The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.
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Caspase 8
Caspase-8 is a caspase protein, encoded by the CASP8 gene.
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Chemotherapy
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.
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Chromosome 10
Chromosome 10 is one of the 23 pairs of chromosomes in humans.
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Cornea
The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber.
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Cysteine
Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.
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Cytochrome c
The cytochrome complex, or cyt c is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion.
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Cytotoxic T cell
A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
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Death domain
The death domain (DD) is a protein interaction module composed of a bundle of six alpha-helices.
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Death effector domain
The death-effector domain (DED) is a protein interaction domain found only in eukaryotes that regulates a variety of cellular signalling pathways.
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Death-inducing signaling complex
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.
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Decoy receptor 3
Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.
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Diablo homolog
Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12.
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Eugene C. Butcher
Eugene C. "Gene" Butcher, M.D. (born 6 January 1950) is an immunologist and a Professor of Pathology at Stanford University.
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Ezrin
Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.
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FADD
Fas-associated protein with death domain (FADD), also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.
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FAF1
FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.
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Fas receptor
The first apoptosis signal receptor (Fas or FasR), also known as apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6) is a protein that in humans is encoded by the FAS gene.
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FNBP1
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.
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FYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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Haplotype
A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent.
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Homeostasis
Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.
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Homotrimer
Trimeric form of a TNF-α mutant A homotrimer is a protein which is composed of three identical units of polypeptide.
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Immune privilege
Certain sites of the human body have immune privilege, meaning they are able to tolerate the introduction of antigens without eliciting an inflammatory immune response.
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Immune response
The Immune response is the body's response caused by its immune system being activated by antigens.
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Immune system
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
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Inhibitor of apoptosis
Apoptosis, or programmed cell death, is a highly regulated process used by many multicellular organisms.
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Lupus erythematosus
Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues.
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Lymphadenopathy
Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number, or consistency.
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Lymphocyte
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.
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Matrix metalloproteinase
Matrix metalloproteinases (MMPs), also known as matrixins, are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins.
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PACSIN2
Protein kinase C and casein kinase substrate in neurons protein 2 (Pacsin 2) is a protein that in humans is encoded by the PACSIN2 gene.
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Perforin
Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Splenomegaly
Splenomegaly is an enlargement of the spleen.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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Testicle
The testicle or testis is the male reproductive gland in all animals, including humans.
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Transmembrane protein
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.
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Tumor necrosis factor superfamily
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers.
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Vascular endothelial growth inhibitor
Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene.
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Redirects here:
CD178, FAS ligand, FASLG, FASLG (gene), Fas ligand protein, TNFSF6.
References
[1] https://en.wikipedia.org/wiki/Fas_ligand
