117 relations: Absorption (pharmacology), Aldehyde dehydrogenase, Allopregnanolone, Ambiguity, Anabolic steroid, Androgen, Androstane, Antiandrogen, Anxiety, Association football, Azasteroid, Benign prostatic hyperplasia, Binding selectivity, Bioavailability, Biological half-life, Biosynthesis, Birth defect, Blood–brain barrier, Bobsleigh, Brain, Butyl group, Carboxylic acid, Caribbean, Case report, Chemoprophylaxis, Clinical trial, Cmax (pharmacology), Cochrane (organisation), CYP3A4, Depression (mood), Dihydrotestosterone, Donald Trump, Dutasteride, Elimination (pharmacology), Enzyme, Enzyme inhibitor, Epididymis, Erectile dysfunction, Estrogen (medication), Feces, Food and Drug Administration, GABAA receptor, Generic drug, Goaltender, Gynecomastia, Hair follicle, Harold Bornstein, HealthNewsReview.org, Hirsutism, Hydroxylation, ..., Hyperandrogenism, Hypoactive sexual desire disorder, Hypospermia, Intersex, Isozyme, José Théodore, Lipophilicity, Liver, Medicare (United States), Merck & Co., Meta-analysis, Metabolism, Metabolite, Minoxidil, Mutation, Neurosteroid, Neurosteroidogenesis inhibitor, Oral administration, Organic compound, P. Roy Vagelos, Pattern hair loss, Persistent adrenarche syndrome, Plasma protein binding, Potency (pharmacology), Precursor (chemistry), Pregnancy, Pregnancy category, President of the United States, Press release, Prostate, Prostate cancer, Prostate-specific antigen, Protein isoform, Quality of life, Reagent, Romário, Sébastien Gattuso, Scalp, Semen, Sex steroid, Sexual dysfunction, Side chain, Side effect, Skeleton (sport), Skin, SRD5A1, SRD5A2, SRD5A3, Steady state, Steroid, Steroid hormone, Structural analog, Tamsulosin, Testosterone, Tissue (biology), Trademark distinctiveness, Trans woman, Transgender hormone therapy (male-to-female), Urine, Volume of distribution, World Anti-Doping Agency, Zach Lund, 3α-Androstanediol, 5α-Reductase, 5α-Reductase deficiency, 5α-Reductase inhibitor, 5β-Reductase. Expand index (67 more) » « Shrink index
In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to bloodstream.
Aldehyde dehydrogenases are a group of enzymes that catalyse the oxidation of aldehydes.
Allopregnanolone, also known as 5α-pregnan-3α-ol-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), as well as brexanolone, is an endogenous inhibitory pregnane neurosteroid.
Ambiguity is a type of meaning in which several interpretations are plausible.
Anabolic steroids, also known more properly as anabolic–androgenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone.
An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.
Androstane is a C19 steroid with a gonane core.
Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone (DHT) from mediating their biological effects in the body.
Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.
Association football, more commonly known as football or soccer, is a team sport played between two teams of eleven players with a spherical ball.
An azasteroid is a type of steroid derivative which has one of the carbon atoms in the steroid ring system replaced by a nitrogen atom.
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate.
Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
A birth defect, also known as a congenital disorder, is a condition present at birth regardless of its cause.
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
Bobsleigh or bobsled is a winter sport in which teams of two or four teammates make timed runs down narrow, twisting, banked, iced tracks in a gravity-powered sleigh.
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
In organic chemistry, butyl is a four-carbon alkyl radical or substituent group with general chemical formula −C4H9, derived from either of the two isomers of butane.
A carboxylic acid is an organic compound that contains a carboxyl group (C(.
The Caribbean is a region that consists of the Caribbean Sea, its islands (some surrounded by the Caribbean Sea and some bordering both the Caribbean Sea and the North Atlantic Ocean) and the surrounding coasts.
In medicine, a case report is a detailed report of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient.
Chemoprevention (also Chemoprophylaxis) refers to the administration of a medication for the purpose of preventing disease or infection.
Clinical trials are experiments or observations done in clinical research.
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
Cochrane is a non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers.
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.
Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone.
Donald John Trump (born June 14, 1946) is the 45th and current President of the United States, in office since January 20, 2017.
Dutasteride, sold under the brand name Avodart among others, is a medication used primarily to treat enlarged prostate in men.
In pharmacology the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.
Enzymes are macromolecular biological catalysts.
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
The epididymis (plural: epididymides or) is a tube that connects a testicle to a vas deferens in the male reproductive system.
Erectile dysfunction (ED), also known as impotence, is a type of sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual activity.
An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.
In ice hockey, the goaltender is the player responsible for preventing the hockey puck from entering their team's net, thus preventing the opposing team from scoring.
Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.
The hair follicle is a dynamic organ found in mammalian skin.
Harold Nelson Bornstein is an American gastroenterologist.
HealthNewsReview.org is a web-based project that rates the completeness, accuracy, and balance of news stories that include claims about medical treatments, tests, products and procedures.
Hirsutism is excessive body hair in men and women on parts of the body where hair is normally absent or minimal, such as on the chin or chest in particular, or the face or body in general.
Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.
Hyperandrogenism, also known as androgen excess, is a medical condition characterized by excessive levels of androgens (male sex hormones such as testosterone) in the female body and the associated effects of the elevated androgen levels.
Hypoactive sexual desire disorder (HSDD) or inhibited sexual desire (ISD) is considered a sexual dysfunction and is characterized as a lack or absence of sexual fantasies and desire for sexual activity, as judged by a clinician.
Hypospermia is a condition in which a man has an unusually low ejaculate (or semen) volume, less than 1.5 ml.
Intersex people are born with any of several variations in sex characteristics including chromosomes, gonads, sex hormones, or genitals that, according to the UN Office of the High Commissioner for Human Rights, "do not fit the typical definitions for male or female bodies".
Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.
José Nicolas Théodore (born September 13, 1976) is a Canadian former professional ice hockey goaltender.
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly"), refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
In the United States, Medicare is a national health insurance program, now administered by the Centers for Medicaid and Medicare Services of the U.S. federal government but begun in 1966 under the Social Security Administration.
Merck & Company, Inc., d.b.a. Merck Sharp & Dohme (MSD) outside the United States and Canada, is an American pharmaceutical company and one of the largest pharmaceutical companies in the world.
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies.
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
A metabolite is the intermediate end product of metabolism.
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.
A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids.
In chemistry, an organic compound is generally any chemical compound that contains carbon.
Pindaros Roy Vagelos (born October 8, 1929 in Westfield, New Jersey), better known as P. Roy Vagelos or Roy Vagelos, is an American physician and business executive, who was president and chief executive officer (1985) and chairman (1986) of the American pharmaceutical company Merck & Co. (known as MSD outside the U.S.). He attracted research scientists who developed many major new drugs.
Pattern hair loss, known as male-pattern hair loss (MPHL) when it affects males and female-pattern hair loss (FPHL) when it affects females, is hair loss that primarily affects the top and front of the scalp.
Persistent adrenarche syndrome (also known as "Adrenal SAHA syndrome") is a cutaneous condition seen typically in thin young women who report great psychological and physical stress in their lives.
Plasma protein binding refers to the degree to which medications attach to proteins within the blood.
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.
Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy.
The President of the United States (POTUS) is the head of state and head of government of the United States of America.
A press release, news release, media release, press statement or video release is a written or recorded communication directed at members of the news media for the purpose of announcing something ostensibly newsworthy.
The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia.
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
Quality of life (QOL) is the general well-being of individuals and societies, outlining negative and positive features of life.
A reagent is a substance or compound added to a system to cause a chemical reaction, or added to test if a reaction occurs.
Romário de Souza Faria (born 29 January 1966), known simply as Romário, is a Brazilian politician who previously achieved worldwide fame as a professional footballer.
Sébastien Gattuso (born 28 June 1971) is a Monegasque athlete specializing in the 100 metres.
The scalp is the anatomical area bordered by the face at the front, and by the neck at the sides and back.
Semen, also known as seminal fluid, is an organic fluid that may contain spermatozoa.
Sex steroids, also known as gonadocorticoids and gonadal steroids, are steroid hormones that interact with vertebrate androgen or estrogen receptors.
Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.
In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called "main chain" or backbone.
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
Skeleton is a winter sliding sport in which a person rides a small sled, known as a skeleton bobsled (or -sleigh), down a frozen track while lying face down and head-first.
Skin is the soft outer tissue covering vertebrates.
3-oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene.
3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.
Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.
In systems theory, a system or a process is in a steady state if the variables (called state variables) which define the behavior of the system or the process are unchanging in time.
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.
A steroid hormone is a steroid that acts as a hormone.
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
Tamsulosin, sold under the trade name Alna ® / Flomax ®, is a medication used to treat symptomatic benign prostatic hyperplasia (BPH) and chronic prostatitis, help with the passage of kidney stones, and for urinary retention along with other measures.
Testosterone is the primary male sex hormone and an anabolic steroid.
In biology, tissue is a cellular organizational level between cells and a complete organ.
Trademark distinctiveness is an important concept in the law governing trademarks and service marks.
A trans woman (sometimes trans-woman or transwoman) is a woman who was assigned male at birth.
Transgender hormone therapy of the male-to-female (MTF) type, also known as feminizing hormone therapy, is a form of hormone replacement therapy (HRT) and sex reassignment therapy which is used to change the secondary sexual characteristics of transgender people from masculine (or androgynous) to feminine.
Urine is a liquid by-product of metabolism in humans and in many animals.
In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.
The World Anti-Doping Agency (WADA; Agence mondiale antidopage, AMA) is a foundation initiated by the International Olympic Committee based in Canada to promote, coordinate and monitor the fight against drugs in sports.
Zach Lund (born March 22, 1979) is an American skeleton racer who has competed since 2000.
3α-Androstanediol (often abbreviated as 3α-diol), also known as 5α-androstane-3α,17β-diol, is an endogenous inhibitory androstane neurosteroid and weak androgen, and a major metabolite of dihydrotestosterone (DHT).
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism.
5α-Reductase deficiency (5-ARD) is an autosomal recessive intersex condition caused by a mutation of the 5α reductase type II gene.
5α-Reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers, are a class of medications with antiandrogenic effects which are used primarily in the treatment of enlarged prostate and scalp hair loss.
5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.
ATC code D11AX10, ATC code G04CB01, ATCvet code QD11AX10, ATCvet code QG04CB01, Appecia, C23H36N2O2, Chibro-Proscar, Finalo, Finara, Finasterid, Finastid, Finax, Fincar, Finpecia, Gefina, L 652,931, L 652931, L-652,931, L-652931, L652,931, L652931, MK 906, MK-906, MK906, Post-Finasteride Syndrome, Post-finasteride Syndrome, Post-finasteride syndrome, Procecia, Propecia, Proscar, Prosteride, Prostide, YM 152, YM-152, YM152.