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53 relations: Alcohol, Amiodarone, Antiarrhythmic agent, Arrhythmogenic right ventricular dysplasia, Artificial cardiac pacemaker, Atrial fibrillation, AV nodal reentrant tachycardia, Bioavailability, Brugada syndrome, Calcium sparks, Cardiac action potential, Cardiac Arrhythmia Suppression Trial, Cardiac muscle, Catecholaminergic polymorphic ventricular tachycardia, Cimetidine, Circulation Research, Coronary artery disease, CYP2D6, Cytochrome P450, Digoxin, Ejection fraction, Electrical conduction system of the heart, Electrocardiography, Encainide, Half-life, Heart, Heart arrhythmia, Heart failure, Hypokalemia, Interstitial lung disease, Kidney, Left ventricular hypertrophy, Molecular Pharmacology, Nav1.5, Paroxetine, Patent, Pediatrics, Premature ventricular contraction, Proarrhythmia, Propafenone, Quinidine, Racemic mixture, Ryanodine receptor 2, Sarcoplasmic reticulum, Sodium, Sodium bicarbonate, Sodium channel, Supraventricular tachycardia, Tachycardia, Torsades de pointes, ..., Ventricular tachycardia, Wolff–Parkinson–White syndrome, 3M. Expand index (3 more) »
Alcohol
In chemistry, an alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a carbon.
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Amiodarone
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats.
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Antiarrhythmic agent
Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a group of pharmaceuticals that are used to suppress abnormal rhythms of the heart (cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
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Arrhythmogenic right ventricular dysplasia
Arrhythmogenic right ventricular dysplasia (ARVD), or arrhythmogenic right ventricular cardiomyopathy (ARVC), is an inherited heart disease.
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Artificial cardiac pacemaker
A pacemaker (or artificial pacemaker, so as not to be confused with the heart's natural pacemaker) is a medical device that generates electrical impulses delivered by electrodes to contract the heart muscles and regulate the electrical conduction system of the heart.
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Atrial fibrillation
Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm characterized by rapid and irregular beating of the atria.
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AV nodal reentrant tachycardia
AV nodal reentrant tachycardia (AVNRT), or atrioventricular nodal reentrant tachycardia, is a type of abnormal fast heart rhythm.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Brugada syndrome
Brugada syndrome (BrS) is a genetic condition that results in abnormal electrical activity within the heart, increasing the risk of sudden cardiac death.
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Calcium sparks
A calcium spark is the microscopic release of calcium (Ca2+) from a store known as the sarcoplasmic reticulum (SR), located within muscle cells.
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Cardiac action potential
The cardiac action potential is a brief change in voltage (membrane potential) across the cell membrane of heart cells.
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Cardiac Arrhythmia Suppression Trial
The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized, controlled study designed to test the hypothesis that suppression of premature ventricular complexes (PVC) with class I antiarrhythmic agents after a myocardial infarction (MI) would reduce mortality.
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Cardiac muscle
Cardiac muscle (heart muscle) is one of the three major types of muscle, the others being skeletal and smooth muscle.
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Catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disorder that predisposes those affected to potentially life-threatening abnormal heart rhythms or arrhythmias.
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Cimetidine
Cimetidine, sold under the brand name Tagamet among others, is a histamine H2 receptor antagonist that inhibits stomach acid production.
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Circulation Research
Circulation Research is a biweekly peer-reviewed medical journal published by Lippincott Williams & Wilkins and edited by Roberto Bolli.
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Coronary artery disease
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Digoxin
Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions.
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Ejection fraction
An ejection fraction (EF) is the volumetric fraction of fluid (usually blood) ejected from a chamber (usually the heart) with each contraction (or heartbeat).
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Electrical conduction system of the heart
The electrical conduction system of the heart transmits signals generated usually by the sinoatrial node to cause contraction of the heart muscle.
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Electrocardiography
Electrocardiography (ECG or EKG) is the process of recording the electrical activity of the heart over a period of time using electrodes placed on the skin.
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Encainide
Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent.
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Half-life
Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.
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Heart
The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.
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Heart arrhythmia
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
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Heart failure
Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.
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Hypokalemia
Hypokalemia, also spelled hypokalaemia, is a low level of potassium (K+) in the blood serum.
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Interstitial lung disease
Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), is a group of lung diseases affecting the interstitium (the tissue and space around the air sacs of the lungs).
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Left ventricular hypertrophy
Left ventricular hypertrophy (LVH) is thickening of the heart muscle of the left ventricle of the heart, that is, left-sided ventricular hypertrophy.
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Molecular Pharmacology
Molecular Pharmacology is a peer-reviewed scientific journal published by the American Society for Pharmacology and Experimental Therapeutics since 1965.
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Nav1.5
NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit.
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Paroxetine
Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.
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Patent
A patent is a set of exclusive rights granted by a sovereign state or intergovernmental organization to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention.
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Pediatrics
Pediatrics (also spelled paediatrics or pædiatrics) is the branch of medicine that involves the medical care of infants, children, and adolescents.
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Premature ventricular contraction
A premature ventricular contraction (PVC)—also known as a premature ventricular complex, ventricular premature contraction (or complex or complexes) (VPC), ventricular premature beat (VPB), or ventricular extrasystole (VES)—is a relatively common event where the heartbeat is initiated by Purkinje fibers in the ventricles rather than by the sinoatrial node, the normal heartbeat initiator.
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Proarrhythmia
Proarrhythmia is a new or more frequent occurrence of pre-existing arrhythmias, paradoxically precipitated by antiarrhythmic therapy, which means it is a side effect associated with the administration of some existing antiarrhythmic drugs, as well as drugs for other indications.
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Propafenone
Propafenone (brand name Rythmol SR or Rytmonorm) is a class 1C anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
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Quinidine
Quinidine is a pharmaceutical agent that acts as a class I antiarrhythmic agent (Ia) in the heart.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Ryanodine receptor 2
Ryanodine receptor 2 (RYR2) is a protein found primarily in cardiac muscle.
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Sarcoplasmic reticulum
The sarcoplasmic reticulum (SR) is a membrane-bound structure found within muscle cells that is similar to the endoplasmic reticulum in other cells.
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Sodium
Sodium is a chemical element with symbol Na (from Latin natrium) and atomic number 11.
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Sodium bicarbonate
Sodium bicarbonate (IUPAC name: sodium hydrogen carbonate), commonly known as baking soda, is a chemical compound with the formula NaHCO3.
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Sodium channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
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Supraventricular tachycardia
Supraventricular tachycardia (SVT) is an abnormally fast heart rhythm arising from improper electrical activity in the upper part of the heart.
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Tachycardia
Tachycardia, also called tachyarrhythmia, is a heart rate that exceeds the normal resting rate.
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Torsades de pointes
Torsades de pointes or torsade depointes (TdP or simply torsade(s)) (translated as "twisting of the points"), is a specific type of abnormal heart rhythm that can lead to sudden cardiac death.
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Ventricular tachycardia
Ventricular tachycardia (V-tach or VT) is a type of regular and fast heart rate that arises from improper electrical activity in the ventricles of the heart.
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Wolff–Parkinson–White syndrome
Wolff–Parkinson–White syndrome (WPWS) is a disorder due to a specific type of problem with the electrical system of the heart which has resulted in symptoms.
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3M
The 3M Company, formerly known as the Minnesota Mining and Manufacturing Company, is an American multinational conglomerate corporation based in Maplewood, Minnesota, a suburb of St. Paul.
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Redirects here:
ATC code C01BC04, ATCvet code QC01BC04, Almarytm, Apocard, C17H20F6N2O3, Flecaine, Flecainide acetate, Tambocor.
References
[1] https://en.wikipedia.org/wiki/Flecainide
