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Follicular B helper T cells

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Follicular B helper T cells (also known as just follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5. [1]

35 relations: Activation-induced cytidine deaminase, Affinity maturation, Antigen, Autoimmune disease, Autoimmunity, B cell, BCL6, CD154, CD278, CD4, CXCR5, Cytotoxic T cell, Follicular B cell, FOXP3, Germinal center, Immunity (medical), Immunization, Immunosenescence, Interleukin 21, Interleukin 4, Lymph node, Memory B cell, Paracrine signalling, Peripheral tolerance, Peyer's patch, Plasma cell, Regulatory T cell, Sjögren syndrome, Somatic hypermutation, Spleen, Systemic lupus erythematosus, T cell, T helper 17 cell, T helper cell, Vaccine.

Activation-induced cytidine deaminase

Activation-induced cytidine deaminase, also known as AICDA and AID, is a 24 kDa enzyme which in humans is encoded by the AICDA gene.

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Affinity maturation

In immunology, affinity maturation is the process by which Tfh cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response.

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Antigen

In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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Autoimmunity

Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues.

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B cell

B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.

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BCL6

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.

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CD154

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules.

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CD278

Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene.

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CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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CXCR5

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family.

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Cytotoxic T cell

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.

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Follicular B cell

Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary lymphoid organs, including spleen and lymph nodes.

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FOXP3

FOXP3 (forkhead box P3), also known as scurfin, is a protein involved in immune system responses.

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Germinal center

Germinal centers or germinal centres (GCs) are sites within secondary lymphoid organs – lymph nodes and the spleen where mature B cells proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity), and switch the class of their antibodies (for example from IgM to IgG) during a normal immune response to an infection.

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Immunity (medical)

In biology, immunity is the balanced state of multicellular organisms having adequate biological defenses to fight infection, disease, or other unwanted biological invasion, while having adequate tolerance to avoid allergy, and autoimmune diseases.

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Immunization

Immunization, or immunisation, is the process by which an individual's immune system becomes fortified against an agent (known as the immunogen).

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Immunosenescence

Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement.

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Interleukin 21

Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene.

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Interleukin 4

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Memory B cell

Memory B cells are a B cell sub-type that are formed within germinal centers following primary infection and are important in generating an accelerated and more robust antibody-mediated immune response in the case of re-infection (also known as a secondary immune response).

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Paracrine signalling

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.

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Peripheral tolerance

Peripheral tolerance is the second branch of immunological tolerance, after central tolerance.

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Peyer's patch

Peyer's patches (or aggregated lymphoid nodules, or occasionally PP for brevity) are organized lymphoid follicles, named after the 17th-century Swiss anatomist Johann Conrad Peyer.

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Plasma cell

Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies.

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Regulatory T cell

The regulatory T cells (Tregs), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.

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Sjögren syndrome

Sjögren syndrome (SjS, SS) is a long-term autoimmune disease in which the moisture-producing glands of the body are affected.

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Somatic hypermutation

Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), as seen during class switching.

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Spleen

The spleen is an organ found in virtually all vertebrates.

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T helper 17 cell

T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).

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T helper cell

The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.

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Vaccine

A vaccine is a biological preparation that provides active acquired immunity to a particular disease.

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Redirects here:

Follicular B Helper T cells, Follicular helper T cells, ThF.

References

[1] https://en.wikipedia.org/wiki/Follicular_B_helper_T_cells

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