63 relations: African clawed frog, AP-1 transcription factor, Ataxia telangiectasia and Rad3 related, Ataxia telangiectasia mutated, Biochemical switches in the cell cycle, C-terminus, Cancer, Cdc25, Cdc6, Cdr2 (S. pombe), Cell cycle, Cell nucleus, Centrosome, CHEK1, CHEK2, Chromatin, Chromosome, Consensus sequence, Cyclin A2, Cyclin B1, Cyclin B2, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cytoplasm, DNA, DNA repair, DNA replication, Drosophila, ETS transcription factor family, Extracellular signal-regulated kinases, G1 phase, Gadd45, Gene regulatory network, Histone H1, Homology (biology), Hysteresis, Interphase, Kinase, Lamin, Maturation promoting factor, Microtubule-associated protein, Mitosis, Myc, Nuclear export signal, P21, P53, Phosphatase, PLK1, Positive feedback, Promoter (genetics), ..., Prophase, Protein, Protein domain, Protein isoform, S phase, Schizosaccharomyces pombe, Serine, Stratifin, TFE3, Transcription factor, Vertebrate, Wee1, Xenopus. Expand index (13 more) » « Shrink index
The African clawed frog (Xenopus laevis, also known as the xenopus, African clawed toad, African claw-toed frog or the platanna) is a species of African aquatic frog of the Pipidae family.
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In the field of molecular biology, the activator protein 1 (AP-1) is a transcription factor which is a heterodimeric protein composed of proteins belonging to the c-Fos, c-Jun, ATF and JDP families.
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene.
Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks.
A series of biochemical switches control transitions between and within the various phases of the cell cycle.
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cancer, also known as a malignant tumor or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cdc25 is a dual-specificity phosphatase first isolated from the yeast Schizosaccharomyces pombe as a cell cycle defective mutant.
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Cdc6, or cell division cycle 6, is a protein in eukaryotic cells that is studied in the budding yeast Saccharomyces cerevisiae.
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Cdr2 is a serine/threonine protein kinase mitotic regulator in the fission yeast S. pombe.
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The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication (replication) that produces two daughter cells.
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In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel) is a membrane-enclosed organelle found in eukaryotic cells.
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In cell biology, the centrosome (Latin centrum 'center' + Greek sōma 'body') is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell as well as a regulator of cell-cycle progression.
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Checkpoint kinase 1, commonly referred to as Chk1 is an Serine/threonine-specific protein kinase that in humans, is encoded by the CHEK1 gene.
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CHEK2 is the official symbol for the human gene Checkpoint kinase 2.
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Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein and RNA.
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A chromosome (''chromo-'' + ''-some'') is a packaged and organized structure containing most of the DNA of a living organism.
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In molecular biology and bioinformatics, the consensus sequence is the calculated order of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment.
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Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene.
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G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene.
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G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.
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Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation.
Cyclin-dependent kinase 2, also known as cell division protein kinase 2, is an enzyme that in humans is encoded by the CDK2 gene.
The cytoplasm comprises cytosol (the gel-like substance enclosed within the cell membrane) – and the organelles – the cell's internal sub-structures.
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Deoxyribonucleic acid (DNA) is a molecule that carries most of the genetic instructions used in the development, functioning and reproduction of all known living organisms and many viruses.
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DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
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DNA replication is the process of producing two identical replicas from one original DNA molecule.
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Drosophila is a genus of small flies, belonging to the family Drosophilidae, whose members are often called "fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.
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In the field of molecular biology, the ETS (E26 transformation-specific or E-twenty-six) family is one of the largest families of transcription factors and is unique to metazoans.
In molecular biology, extracellular-signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.
The G1 phase, or Growth 1/Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.
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The Growth Arrest and DNA Damage or gadd45 genes, including GADD45A (originally termed gadd45) GADD45B (originally termed MyD118), and GADD45G (originally termed CR6), are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation.
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A gene regulatory network or genetic regulatory network (GRN) is a collection of regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins.
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Histone H1 is one of the five main histone protein families which are components of chromatin in eukaryotic cells.
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In the context of biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different species.
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Hysteresis is the time-based dependence of a system's output on present and past inputs.
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Interphase is the phase of the cell cycle in which a typical cell spends most of its life.
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In biochemistry, a kinase is a type of enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.
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Nuclear lamins (not to be confused with laminins), also known as Class V intermediate filaments, are fibrous proteins providing structural function and transcriptional regulation in the cell nucleus.
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Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs.
In cell biology, microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton.
Mitosis is a part of the cell cycle in which chromosomes in a cell nucleus are separated into two identical sets of chromosomes, each in its own nucleus.
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Myc (c-Myc) is a regulator gene that codes for a transcription factor.
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A nuclear export signal (NES) is a short amino acid sequence of 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex using nuclear transport.
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p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor that inhibits the complexes of CDK2 and CDK1.
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Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
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A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation).
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Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.
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Positive feedback is a process that occurs in a feedback loop in which the effects of a small disturbance on a system include an increase in the magnitude of the perturbation.
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In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.
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Prophase (from the Greek πρό, "before" and φάσις, "stage"), is a stage of mitosis in which the chromatin condenses into double rod-shaped structures called chromosomes in which the chromatin becomes visible.
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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
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A protein isoform is any of several different forms of the same protein.
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S-phase (synthesis phase) is the part of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.
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Schizosaccharomyces pombe, also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology.
Serine (abbreviated as Ser or S) is an amino acid with the formula HO2CCH(NH2)CH2OH.
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14-3-3 protein sigma, or 14-3-3σ protein is a protein that is in humans and is encoded by the SFN gene.
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Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene.
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In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA.
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Vertebrates comprise any species of animals within the subphylum Vertebrata (chordates with backbones).
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Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe).
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Xenopus (Gk., ξενος, xenos.
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