Table of Contents
160 relations: Action potential, Active site, Adipiplon, Agonist, Alcohol (drug), Allosteric modulator, Allosteric regulation, Amentoflavone, Amnesia, Anesthetic, Anticonvulsant, Anxiogenic, Anxiolytic, Ataxia, Baicalin, Barbiturate, Benzodiazepine, Bicarbonate, Bicuculline, Bretazenil, Carbamate, Carisoprodol, Cell membrane, Cell proliferation, Cell surface receptor, Central nervous system, Channel blocker, Chemical synapse, Chloride, Chloride potassium symporter 5, Cicutoxin, CL-218,872, Convulsion, Dendrite, Depolarization, Diproqualone, Endocrine system, Endogeny (biology), Epigallocatechin gallate, Epigenetics, Epiphyseal plate, Eszopiclone, Etaqualone, Ethanol, Etomidate, Euphoria, Flumazenil, GABA, GABA receptor, GABAA receptor negative allosteric modulator, ... Expand index (110 more) »
- GABA
- Transmembrane receptors
Action potential
An action potential occurs when the membrane potential of a specific cell rapidly rises and falls.
See GABAA receptor and Action potential
Active site
In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.
See GABAA receptor and Active site
Adipiplon
Adipiplon (developmental code name NG2-73) is an anxiolytic drug developed by Neurogen Corporation.
See GABAA receptor and Adipiplon
Agonist
An agonist is a chemical that activates a receptor to produce a biological response.
See GABAA receptor and Agonist
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ethanol, is one of the most widely used and abused psychoactive drugs in the world and falls under the depressant category.
See GABAA receptor and Alcohol (drug)
Allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli.
See GABAA receptor and Allosteric modulator
Allosteric regulation
In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.
See GABAA receptor and Allosteric regulation
Amentoflavone
Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3 positions, or 3,8-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Biophytum sensitivum, Selaginella tamariscina, Hypericum perforatum (St. John's Wort) and Xerophyta plicata.
See GABAA receptor and Amentoflavone
Amnesia
Amnesia is a deficit in memory caused by brain damage or brain diseases,Gazzaniga, M., Ivry, R., & Mangun, G. (2009) Cognitive Neuroscience: The biology of the mind.
See GABAA receptor and Amnesia
Anesthetic
An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia — in other words, to result in a temporary loss of sensation or awareness.
See GABAA receptor and Anesthetic
Anticonvulsant
Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
See GABAA receptor and Anticonvulsant
Anxiogenic
An anxiogenic or panicogenic substance is one that causes anxiety.
See GABAA receptor and Anxiogenic
Anxiolytic
An anxiolytic (also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety.
See GABAA receptor and Anxiolytic
Ataxia
Ataxia (from Greek α- + -τάξις.
Baicalin
As baicalin is a flavone glycoside, it is a flavonoid.
See GABAA receptor and Baicalin
Barbiturate
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid.
See GABAA receptor and Barbiturate
Benzodiazepine
Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
See GABAA receptor and Benzodiazepine
Bicarbonate
In inorganic chemistry, bicarbonate (IUPAC-recommended nomenclature: hydrogencarbonate) is an intermediate form in the deprotonation of carbonic acid.
See GABAA receptor and Bicarbonate
Bicuculline
Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors.
See GABAA receptor and Bicuculline
Bretazenil
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug which is derived from the benzodiazepine family, and was invented in 1988.
See GABAA receptor and Bretazenil
Carbamate
In organic chemistry, a carbamate is a category of organic compounds with the general formula and structure, which are formally derived from carbamic acid.
See GABAA receptor and Carbamate
Carisoprodol
Carisoprodol, sold under the brand name Soma among others, is a medication used for musculoskeletal pain.
See GABAA receptor and Carisoprodol
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
See GABAA receptor and Cell membrane
Cell proliferation
Cell proliferation is the process by which a cell grows and divides to produce two daughter cells.
See GABAA receptor and Cell proliferation
Cell surface receptor
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. GABAA receptor and cell surface receptor are transmembrane receptors.
See GABAA receptor and Cell surface receptor
Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord.
See GABAA receptor and Central nervous system
Channel blocker
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell.
See GABAA receptor and Channel blocker
Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles or glands.
See GABAA receptor and Chemical synapse
Chloride
The term chloride refers to a compound or molecule that contains either a chlorine ion, which is a negatively charged chlorine atom, or a non-charged chlorine atom covalently bonded to the rest of the molecule by a single bond.
See GABAA receptor and Chloride
Chloride potassium symporter 5
Potassium-chloride transporter member 5 (aka: KCC2 and SLC12A5) is a neuron-specific chloride potassium symporter responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations.
See GABAA receptor and Chloride potassium symporter 5
Cicutoxin
Cicutoxin is a naturally-occurring poisonous chemical compound produced by several plants from the family Apiaceae including water hemlock (Cicuta species) and water dropwort (Oenanthe crocata).
See GABAA receptor and Cicutoxin
CL-218,872
CL-218,872 is a sedative and hypnotic drug used in scientific research.
See GABAA receptor and CL-218,872
Convulsion
A convulsion is a medical condition where the body muscles contract and relax rapidly and repeatedly, resulting in uncontrolled shaking.
See GABAA receptor and Convulsion
Dendrite
A dendrite (from Greek δένδρον déndron, "tree") or dendron is a branched protoplasmic extension of a nerve cell that propagates the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project.
See GABAA receptor and Dendrite
Depolarization
In biology, depolarization or hypopolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell compared to the outside.
See GABAA receptor and Depolarization
Diproqualone
Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique.
See GABAA receptor and Diproqualone
Endocrine system
The endocrine system is a messenger system in an organism comprising feedback loops of hormones that are released by internal glands directly into the circulatory system and that target and regulate distant organs.
See GABAA receptor and Endocrine system
Endogeny (biology)
Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.
See GABAA receptor and Endogeny (biology)
Epigallocatechin gallate
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin.
See GABAA receptor and Epigallocatechin gallate
Epigenetics
In biology, epigenetics is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence.
See GABAA receptor and Epigenetics
Epiphyseal plate
The epiphyseal plate, epiphysial plate, physis, or growth plate is a hyaline cartilage plate in the metaphysis at each end of a long bone.
See GABAA receptor and Epiphyseal plate
Eszopiclone
Eszopiclone, sold under the brand name Lunesta among others, is a medication used in the treatment of insomnia.
See GABAA receptor and Eszopiclone
Etaqualone
Etaqualone (Aolan, Athinazone, Ethinazone) is a quinazolinone-class GABAergic and is an analogue of methaqualone that was developed in the 1960s and marketed mainly in France and some other European countries.
See GABAA receptor and Etaqualone
Ethanol
Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula.
See GABAA receptor and Ethanol
Etomidate
Etomidate (USAN, INN, BAN; marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.
See GABAA receptor and Etomidate
Euphoria
Euphoria is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness.
See GABAA receptor and Euphoria
Flumazenil
Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective GABAA receptor antagonist administered via injection, otic insertion, or intranasally.
See GABAA receptor and Flumazenil
GABA
GABA (gamma Aminobutyric acid, γ-Aminobutyric acid) is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system.
GABA receptor
The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.
See GABAA receptor and GABA receptor
GABAA receptor negative allosteric modulator
A GABAA receptor negative allosteric modulator is a negative allosteric modulator (NAM), or inhibitor, of the GABAA receptor, a ligand-gated ion channel of the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
See GABAA receptor and GABAA receptor negative allosteric modulator
GABAA receptor positive allosteric modulator
In pharmacology, GABAA receptor positive allosteric modulators, also known as GABAkines or GABAA receptor potentiators, are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system.
See GABAA receptor and GABAA receptor positive allosteric modulator
GABAA-rho receptor
The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits. GABAA receptor and GABAA-rho receptor are GABA and transmembrane receptors.
See GABAA receptor and GABAA-rho receptor
GABAB receptor
GABAB receptors (GABABR) are G-protein coupled receptors for gamma-aminobutyric acid (GABA), therefore making them metabotropic receptors, that are linked via G-proteins to potassium channels. GABAA receptor and GABAB receptor are GABA.
See GABAA receptor and GABAB receptor
Gabazine
Gabazine (SR-95531) is a drug that acts as an antagonist at GABAA receptors.
See GABAA receptor and Gabazine
Gaboxadol
Gaboxadol, also known as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a conformationally constrained derivative of the alkaloid muscimol that was first synthesized in 1977 by the Danish chemist Poul Krogsgaard-Larsen.
See GABAA receptor and Gaboxadol
GABRA2
Gamma-aminobutyric acid receptor subunit alpha-2 is a protein in humans that is encoded by the GABRA2 gene. GABAA receptor and GABRA2 are ion channels.
GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3 is a protein that in humans is encoded by the GABRA3 gene. GABAA receptor and GABRA3 are ion channels.
GABRA4
Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene. GABAA receptor and GABRA4 are ion channels.
GABRA5
Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene. GABAA receptor and GABRA5 are ion channels.
GABRA6
Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene. GABAA receptor and GABRA6 are ion channels.
GABRB1
Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene. GABAA receptor and GABRB1 are ion channels.
GABRB2
The GABAA beta-2 subunit is a protein that in humans is encoded by the GABRB2 gene. GABAA receptor and GABRB2 are ion channels.
GABRB3
Gamma-aminobutyric acid receptor subunit beta-3 is a protein that in humans is encoded by the GABRB3 gene. GABAA receptor and GABRB3 are ion channels.
GABRD
Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene. GABAA receptor and GABRD are ion channels.
GABRE
Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene. GABAA receptor and GABRE are ion channels.
GABRG1
Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene. GABAA receptor and GABRG1 are ion channels.
GABRG3
GABAA receptor-γ3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene. GABAA receptor and GABRG3 are ion channels.
GABRP
Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene. GABAA receptor and GABRP are ion channels.
GABRQ
Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene. GABAA receptor and GABRQ are ion channels.
GABRR1
Gamma-aminobutyric acid receptor subunit rho-1 is a protein that in humans is encoded by the GABRR1 gene. GABAA receptor and GABRR1 are ion channels.
GABRR2
Gamma-aminobutyric acid receptor subunit rho-2 is a protein that in humans is encoded by the GABRR2 gene. GABAA receptor and GABRR2 are ion channels.
GABRR3
Gamma-aminobutyric acid receptor subunit rho-3 is a protein that in humans is encoded by the GABRR3 gene. GABAA receptor and GABRR3 are ion channels.
Gamma-aminobutyric acid receptor subunit alpha-1
Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene. GABAA receptor and Gamma-aminobutyric acid receptor subunit alpha-1 are ion channels.
See GABAA receptor and Gamma-aminobutyric acid receptor subunit alpha-1
Gamma-aminobutyric acid receptor subunit gamma-2
Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene. GABAA receptor and gamma-aminobutyric acid receptor subunit gamma-2 are ion channels.
See GABAA receptor and Gamma-aminobutyric acid receptor subunit gamma-2
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.
See GABAA receptor and Genetics
Gephyrin
Gephyrin is a protein that in humans is encoded by the GPHN gene.
See GABAA receptor and Gephyrin
Glutethimide
Glutethimide is a hypnotic sedative that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia.
See GABAA receptor and Glutethimide
Glycine receptor
The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine.
See GABAA receptor and Glycine receptor
Hallucinogen
Hallucinogens are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes.
See GABAA receptor and Hallucinogen
Harmaline
Harmaline is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines.
See GABAA receptor and Harmaline
Harmine
Harmine is a beta-carboline and a harmala alkaloid.
See GABAA receptor and Harmine
Honokiol
Honokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia.
See GABAA receptor and Honokiol
Hypnotic
Hypnotic (from Greek Hypnos, sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia to produce and maintain unconsciousness, "sleep" is metaphorical as there are no regular sleep stages or cyclical natural states; patients rarely recover from anesthesia feeling refreshed and with renewed energy.
See GABAA receptor and Hypnotic
Imidazenil
Imidazenil is an experimental anxiolytic drug which is derived from the benzodiazepine family, and is most closely related to other imidazobenzodiazepines such as midazolam, flumazenil, and bretazenil.
See GABAA receptor and Imidazenil
Inhalational anesthetic
An inhalational anesthetic is a chemical compound possessing general anesthetic properties that is delivered via inhalation.
See GABAA receptor and Inhalational anesthetic
Inhibitory postsynaptic potential
An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential.
See GABAA receptor and Inhibitory postsynaptic potential
Inosine
Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9-glycosidic bond.
See GABAA receptor and Inosine
International Union of Basic and Clinical Pharmacology
The International Union of Basic and Clinical Pharmacology (IUPHAR) is a voluntary, non-profit association representing the interests of scientists in pharmacology-related fields to facilitate Better Medicines through Global Education and Research around the world.
See GABAA receptor and International Union of Basic and Clinical Pharmacology
Ion
An ion is an atom or molecule with a net electrical charge.
Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. GABAA receptor and ion channel are ion channels.
See GABAA receptor and Ion channel
Isoguvacine
Isoguvacine is a GABAA receptor agonist used in scientific research.
See GABAA receptor and Isoguvacine
Β-Alanine
β-Alanine (or beta-alanine) is a naturally occurring beta amino acid, which is an amino acid in which the amino group is attached to the β-carbon (i.e. the carbon two carbon atoms away from the carboxylate group) instead of the more usual α-carbon for alanine (α-alanine).
See GABAA receptor and Β-Alanine
Β-Carboline
β-Carboline (9H-pyridoindole) represents the basic chemical structure for more than one hundred alkaloids and synthetic compounds.
See GABAA receptor and Β-Carboline
Kavalactone
Kavalactones are a class of lactone compounds found in kava roots and Alpinia zerumbet (shell ginger).
See GABAA receptor and Kavalactone
L-838,417
L-838,417 is an anxiolytic drug used in scientific research.
See GABAA receptor and L-838,417
Lanthanum
Lanthanum is a chemical element; it has symbol La and atomic number 57.
See GABAA receptor and Lanthanum
Leydig cell
Leydig cells, also known as interstitial cells of the testes and interstitial cells of Leydig, are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH).
See GABAA receptor and Leydig cell
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See GABAA receptor and Ligand (biochemistry)
Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter. GABAA receptor and ligand-gated ion channel are ion channels.
See GABAA receptor and Ligand-gated ion channel
Lindane
Lindane, also known as gamma-hexachlorocyclohexane (γ-HCH), gammaxene, Gammallin and benzene hexachloride (BHC), is an organochlorine chemical and an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical treatment for lice and scabies.
See GABAA receptor and Lindane
Liver
The liver is a major metabolic organ exclusively found in vertebrate animals, which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and various other biochemicals necessary for digestion and growth.
Lorbamate
Lorbamate (INN; Abbott-19,957) is a muscle relaxant and tranquilizer of the carbamate family which was never marketed.
See GABAA receptor and Lorbamate
Magnolol
Magnolol is an organic compound that is classified as lignan.
See GABAA receptor and Magnolol
Malignancy
Malignancy is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer.
See GABAA receptor and Malignancy
Membrane potential
Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell.
See GABAA receptor and Membrane potential
Menthol
Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints.
See GABAA receptor and Menthol
Meprobamate
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug.
See GABAA receptor and Meprobamate
Methaqualone
Methaqualone is a hypnotic sedative.
See GABAA receptor and Methaqualone
Muscimol
Muscimol is a potent psychoactive compound found in certain mushrooms, most notably the Amanita muscaria and related species of mushroom.
See GABAA receptor and Muscimol
Muscle relaxant
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.
See GABAA receptor and Muscle relaxant
Na–K–Cl cotransporter
The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells.
See GABAA receptor and Na–K–Cl cotransporter
Neuron
A neuron, neurone, or nerve cell is an excitable cell that fires electric signals called action potentials across a neural network in the nervous system.
Neurosteroid
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors.
See GABAA receptor and Neurosteroid
Neurotransmission
Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and react with the receptors on the dendrites of another neuron (the postsynaptic neuron) a short distance away.
See GABAA receptor and Neurotransmission
Neurotransmitter
A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse.
See GABAA receptor and Neurotransmitter
Nicotinamide
Niacinamide or nicotinamide is a form of vitamin B3 found in food and used as a dietary supplement and medication.
See GABAA receptor and Nicotinamide
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. GABAA receptor and Nicotinic acetylcholine receptor are ion channels.
See GABAA receptor and Nicotinic acetylcholine receptor
Nomenclature
Nomenclature is a system of names or terms, or the rules for forming these terms in a particular field of arts or sciences.
See GABAA receptor and Nomenclature
Nonbenzodiazepine
Nonbenzodiazepines, sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia and anxiety.
See GABAA receptor and Nonbenzodiazepine
Nootropic
Nootropics (or; but not or, which are common mispronunciations), colloquially brain supplements, smart drugs and cognitive enhancers, are natural, semisynthetic or synthetic compounds which purportedly improve cognitive functions, such as executive functions, attention or memory.
See GABAA receptor and Nootropic
Occupational burnout
The ICD-11 of the World Health Organization (WHO) describes occupational burnout as an occupational phenomenon resulting from chronic workplace stress that hasn't been successfully managed, with symptoms characterized by "feelings of energy depletion or exhaustion; increased mental distance from one’s job, or feelings of negativism or cynicism related to one's job; and reduced professional efficacy." It is classified as a mismatch between the challenges of work and a person's mental and physical resources, but is not recognized by the WHO as a medical condition.
See GABAA receptor and Occupational burnout
Oenanthotoxin
Oenanthotoxin is a toxin extracted from hemlock water-dropwort (Oenanthe crocata) and other plants of the genus Oenanthe.
See GABAA receptor and Oenanthotoxin
Paradoxical reaction
A paradoxical reaction (or paradoxical effect) is an effect of a chemical substance, such as a medical drug, that is opposite to what would usually be expected.
See GABAA receptor and Paradoxical reaction
Pentamer
A pentamer is an entity composed of five subunits.
See GABAA receptor and Pentamer
Pentylenetetrazol
Pentylenetetrazol, also known as pentylenetetrazole, leptazol, metrazol, pentetrazol (INN), pentamethylenetetrazol, Corazol, Cardiazol, Deumacard, or PTZ, is a drug formerly used as a circulatory and respiratory stimulant.
See GABAA receptor and Pentylenetetrazol
Picrotoxin
Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound.
See GABAA receptor and Picrotoxin
Placenta
The placenta (placentas or placentae) is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation.
See GABAA receptor and Placenta
Pregnenolone sulfate
Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone.
See GABAA receptor and Pregnenolone sulfate
Progabide
Progabide (INN; trade name Gabrene, Sanofi-Aventis) is an analogue and prodrug of γ-aminobutyric acid (GABA) used in the treatment of epilepsy.
See GABAA receptor and Progabide
Propofol
Propofol is the active component of an intravenous anesthetic formulation used for induction and maintenance of general anesthesia.
See GABAA receptor and Propofol
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues.
See GABAA receptor and Protein
Protein isoform
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
See GABAA receptor and Protein isoform
QH-II-66
QH-II-66 (QH-ii-066) is a sedative drug which is a benzodiazepine derivative.
See GABAA receptor and QH-II-66
Quinazolinone
Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C4N2 ring.
See GABAA receptor and Quinazolinone
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
See GABAA receptor and Receptor antagonist
Reversal potential
In a biological membrane, the reversal potential is the membrane potential at which the direction of ionic current reverses.
See GABAA receptor and Reversal potential
Riluzole
Riluzole is a medication used to treat amyotrophic lateral sclerosis and other motor neuron diseases.
See GABAA receptor and Riluzole
Ro15-4513
Ro15-4513 (IUPAC: Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate) is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann–La Roche in the 1980s.
See GABAA receptor and Ro15-4513
Sarmazenil
Sarmazenil (Ro15-3505) is a drug from the benzodiazepine family.
See GABAA receptor and Sarmazenil
Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
See GABAA receptor and Sedation
Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.
See GABAA receptor and Sedative
SL651498
SL651498 is an anxiolytic and anticonvulsant drug used in scientific research, with a chemical structure most closely related to β-carboline derivatives such as abecarnil and gedocarnil.
See GABAA receptor and SL651498
Social stress
Social stress is stress that stems from one's relationships with others and from the social environment in general.
See GABAA receptor and Social stress
Soma (biology)
In cellular neuroscience, the soma (somata or somas), perikaryon (perikarya), neurocyton, or cell body is the bulbous, non-process portion of a neuron or other brain cell type, containing the cell nucleus.
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Stiripentol
Stiripentol, sold under the brand name Diacomit, is an anticonvulsant medication used for the treatment of Dravet syndrome - a serious genetic brain disorder.
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Synapse
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target effector cell.
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Synaptic vesicle
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.
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Taurine
Taurine, or 2-aminoethanesulfonic acid, is a non-proteinogenic naturally occurred amino sulfonic acid that is widely distributed in animal tissues.
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Tetrahydroharmine
Tetrahydroharmine (THH) is a fluorescent indole alkaloid that occurs in the tropical liana species Banisteriopsis caapi.
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Thalamic reticular nucleus
The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally.
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Theanine
Theanine, commonly known as L-theanine and sometimes L-gamma-glutamylethylamide or N5-ethyl-L-glutamine, is an amino acid analogue of the proteinogenic amino acids L-glutamate and L-glutamine and is found primarily in particular plant and fungal species.
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Thienodiazepine
A thienodiazepine is a heterocyclic compound containing a diazepine ring fused to a thiophene ring.
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Translocator protein
Translocator protein (TSPO) is an 18 kDa protein mainly found on the outer mitochondrial membrane.
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Valerenic acid
Valerenic acid is a sesquiterpenoid constituent of the essential oil of the valerian plant.
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Vitamin B3
Vitamin B3, colloquially referred to as niacin, is a vitamin family that includes three forms, or vitamers: niacin (nicotinic acid), nicotinamide (niacinamide), and nicotinamide riboside.
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White blood cell
White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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Zinc
Zinc is a chemical element with the symbol Zn and atomic number 30.
Zolpidem
Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems.
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4-Iodopropofol
4-Iodopropofol is a drug derived from the commonly used sedative anaesthetic agent, propofol.
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin receptors) which are G protein-coupled receptors. GABAA receptor and 5-HT3 receptor are ion channels.
See GABAA receptor and 5-HT3 receptor
See also
GABA
- 4-aminobutyrate transaminase
- GABA
- GABA transporter
- GABA transporter type 2
- GABA transporter type 3
- GABAA receptor
- GABAA-rho receptor
- GABAB receptor
- Gamma-Hydroxybutyric acid
- Glutamate decarboxylase
- Ionotropic GABA receptor
- Rosehip neuron
Transmembrane receptors
- Anton blood group antigen
- BMPR1A
- BMPR1B
- Biogenic amine receptor
- Bone morphogenetic protein receptor, type 1
- Cell surface receptor
- Chemotaxis
- Co-receptor
- E-selectin
- ER-X
- ERx
- Enzyme-linked receptor
- Fc receptors
- GABAA receptor
- GABAA-rho receptor
- Glutamate receptor
- Glycophorin C
- Glycoprotein Ib-IX-V complex
- Immune receptor
- Immune receptors
- Immunoglobulin superfamily
- Inositol trisphosphate receptor
- Integrin-like receptors
- Integrins
- Ionotropic receptors
- Killer cell immunoglobulin-like receptor 2DL3
- Langerin
- Low-density lipoprotein receptor gene family
- Metabotropic receptor
- Methyl-accepting chemotaxis proteins
- Monoamine receptor
- Neuropilin
- Proton coupled amino acid transporter
- Receptor tyrosine phosphatase
- Renin receptor
- Ribosomal protein SA
- Ryanodine receptor
- Sensory rhodopsin II
- Soluble cell adhesion molecules
- TGF beta receptor
- TGF-beta receptor family
- Theseus1
- Toll-like receptors
- Tyrosine kinase receptors
References
Also known as BZ-sensitive GABAA receptor, Benzodiazepine receptor, Benzodiazepine receptors, Benzodiazepine site, Benzodiazepine sites, Central Benzodiazepine Receptor, Central Benzodiazepine Receptors, Central Benzodiazepine Site, Central Benzodiazepine Sites, GABA A receptor, GABA-A, GABA-A receptor, GABAA, GABAA receptors, Gaba-b receptor, Receptors, gaba-a, Γ-Aminobutyric acid A receptor.