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GABAB receptor

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GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels. [1]

51 relations: Absence seizure, Action potential, Adenylyl cyclase, Autonomic nervous system, Baclofen, BHF-177, BHFF, Biochemical Pharmacology (journal), BSPP (drug), C-terminus, Calcium channel, Cell surface receptor, Central nervous system, CGP-35348, CGP-7930, Epilepsy, Ethanol, Fendiline, G protein, GABA receptor, GABAA receptor, GABAA-rho receptor, GABBR1, GABBR2, Gamma-Aminobutyric acid, Gamma-Hydroxybutyric acid, Gi alpha subunit, Ginsenoside, GS-39783, Homotaurine, Ion channel, Isovaline, Lesogaberan, Metabotropic glutamate receptor, Metabotropic receptor, Muscle relaxant, Neuron, Neurotransmitter, Norman Bowery, Peripheral nervous system, Phaclofen, Phenethylamine, Phenibut, Potassium, Protein dimer, Reversal potential, Saclofen, SCH-50911, SKF-97,541, Structural analog, ..., Venus flytrap. Expand index (1 more) »

Absence seizure

Absence seizures are one of several kinds of generalized seizures.

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Action potential

In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.

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Adenylyl cyclase

Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.

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Autonomic nervous system

The autonomic nervous system (ANS), formerly the vegetative nervous system, is a division of the peripheral nervous system that supplies smooth muscle and glands, and thus influences the function of internal organs.

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Baclofen

Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity.

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BHF-177

BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.

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BHFF

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.

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Biochemical Pharmacology (journal)

Biochemical Pharmacology is a peer-reviewed medical journal published by Elsevier.

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BSPP (drug)

BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Calcium channel

A calcium channel is an ion channel which shows selective permeability to calcium ions.

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Cell surface receptor

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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CGP-35348

CGP-35348 is a compound used in scientific research which acts as an antagonist at GABAB receptors.

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CGP-7930

CGP-7930 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.

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Epilepsy

Epilepsy is a group of neurological disorders characterized by epileptic seizures.

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Ethanol

Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.

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Fendiline

Fendiline is a calcium channel blocker.

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G protein

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

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GABA receptor

The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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GABAA-rho receptor

The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits.

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GABBR1

Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

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GABBR2

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.

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Gamma-Aminobutyric acid

gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.

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Gamma-Hydroxybutyric acid

γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug.

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Gi alpha subunit

Gi alpha subunit (Gαi, or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.

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Ginsenoside

Ginsenosides or panaxosides are a class of natural product steroid glycosides and triterpene saponins.

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GS-39783

GS-39783 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.

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Homotaurine

Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a natural organic compound found in seaweed.

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Ion channel

Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.

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Isovaline

Isovaline is a rare amino acid transported to earth by the Murchison meteorite, which landed in Australia in 1969.

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Lesogaberan

Lesogaberan (AZD-3355) was an experimental drug candidate developed by AstraZeneca for the treatment of gastroesophageal reflux disease (GERD).

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Metabotropic glutamate receptor

The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process.

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Metabotropic receptor

A metabotropic receptor is a type of membrane receptor of eukaryotic cells that acts through a second messenger.

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Muscle relaxant

A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.

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Neuron

A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Norman Bowery

Professor Norman Bowery, (1944 - 25 October 2016) was a British pharmacologist and former Head of Division of Neuroscience and Chair of Pharmacology at the University of Birmingham from 1995 to 2004.

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Peripheral nervous system

The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).

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Phaclofen

Phaclofen, or phosphonobaclofen, is a selective antagonist for the GABAB receptor.

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Phenethylamine

Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.

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Phenibut

Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and sedative effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.

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Potassium

Potassium is a chemical element with symbol K (from Neo-Latin kalium) and atomic number 19.

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Reversal potential

In a biological membrane, the reversal potential (also known as the Nernst potential) of an ion is the membrane potential at which there is no net (overall) flow of that particular ion from one side of the membrane to the other.

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Saclofen

Saclofen is a competitive antagonist for the GABAB receptor.

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SCH-50911

SCH-50911 is a selective GABAB antagonist.

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SKF-97,541

SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Venus flytrap

The Venus flytrap (also referred to as Venus's flytrap or Venus' flytrap), Dionaea muscipula, is a carnivorous plant native to subtropical wetlands on the East Coast of the United States in North Carolina and South Carolina.

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Redirects here:

GABA B Receptor, GABA B receptor, GABA-B, GABA-B receptor, GABAB, GABABR, GABAb receptor, Gaba B Receptor, Gaba b receptor, Gabab receptor, Receptors, gaba-b, Γ-Aminobutyric acid B receptor.

References

[1] https://en.wikipedia.org/wiki/GABAB_receptor

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