51 relations: Absence seizure, Action potential, Adenylyl cyclase, Autonomic nervous system, Baclofen, BHF-177, BHFF, Biochemical Pharmacology (journal), BSPP (drug), C-terminus, Calcium channel, Cell surface receptor, Central nervous system, CGP-35348, CGP-7930, Epilepsy, Ethanol, Fendiline, G protein, GABA receptor, GABAA receptor, GABAA-rho receptor, GABBR1, GABBR2, Gamma-Aminobutyric acid, Gamma-Hydroxybutyric acid, Gi alpha subunit, Ginsenoside, GS-39783, Homotaurine, Ion channel, Isovaline, Lesogaberan, Metabotropic glutamate receptor, Metabotropic receptor, Muscle relaxant, Neuron, Neurotransmitter, Norman Bowery, Peripheral nervous system, Phaclofen, Phenethylamine, Phenibut, Potassium, Protein dimer, Reversal potential, Saclofen, SCH-50911, SKF-97,541, Structural analog, ..., Venus flytrap. Expand index (1 more) » « Shrink index
Absence seizures are one of several kinds of generalized seizures.
In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.
Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.
The autonomic nervous system (ANS), formerly the vegetative nervous system, is a division of the peripheral nervous system that supplies smooth muscle and glands, and thus influences the function of internal organs.
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity.
BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.
BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.
Biochemical Pharmacology is a peer-reviewed medical journal published by Elsevier.
BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
A calcium channel is an ion channel which shows selective permeability to calcium ions.
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
CGP-35348 is a compound used in scientific research which acts as an antagonist at GABAB receptors.
CGP-7930 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.
Epilepsy is a group of neurological disorders characterized by epileptic seizures.
Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.
Fendiline is a calcium channel blocker.
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
The GABAA-rho receptor (previously known as the GABAC receptor) is a subclass of GABAA receptors composed entirely of rho (ρ) subunits.
Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.
Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.
gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.
γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug.
Gi alpha subunit (Gαi, or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.
Ginsenosides or panaxosides are a class of natural product steroid glycosides and triterpene saponins.
GS-39783 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.
Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a natural organic compound found in seaweed.
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
Isovaline is a rare amino acid transported to earth by the Murchison meteorite, which landed in Australia in 1969.
Lesogaberan (AZD-3355) was an experimental drug candidate developed by AstraZeneca for the treatment of gastroesophageal reflux disease (GERD).
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process.
A metabotropic receptor is a type of membrane receptor of eukaryotic cells that acts through a second messenger.
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
Neurotransmitters are endogenous chemicals that enable neurotransmission.
Professor Norman Bowery, (1944 - 25 October 2016) was a British pharmacologist and former Head of Division of Neuroscience and Chair of Pharmacology at the University of Birmingham from 1995 to 2004.
The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).
Phaclofen, or phosphonobaclofen, is a selective antagonist for the GABAB receptor.
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.
Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and sedative effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.
Potassium is a chemical element with symbol K (from Neo-Latin kalium) and atomic number 19.
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
In a biological membrane, the reversal potential (also known as the Nernst potential) of an ion is the membrane potential at which there is no net (overall) flow of that particular ion from one side of the membrane to the other.
Saclofen is a competitive antagonist for the GABAB receptor.
SCH-50911 is a selective GABAB antagonist.
SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist.
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
The Venus flytrap (also referred to as Venus's flytrap or Venus' flytrap), Dionaea muscipula, is a carnivorous plant native to subtropical wetlands on the East Coast of the United States in North Carolina and South Carolina.