GFRα

The GDNF family receptor-α (GFRα) proteins are a group of co-receptors which form complexes with GDNF-family ligands (GFLs) to activate RET, the receptor of the GFLs. ^[1]

13 relations: Artemin, Co-receptor, GDNF family of ligands, GFRA1, GFRA2 (gene), GFRA3, GFRA4, Glial cell line-derived neurotrophic factor, Neurturin, Persephin, Protein, Receptor (biochemistry), RET proto-oncogene.

Artemin

Artemin, also known as enovin or neublastin, is a protein that in humans is encoded by the ARTN gene.

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A co-receptor is a cell surface receptor that binds a signalling molecule in addition to a primary receptor in order to facilitate ligand recognition and initiate biological processes, such as entry of a pathogen into a host cell.

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GDNF family of ligands

The GDNF family of ligands (GFL) consists of four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN).

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GFRA1

GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.

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GFRA2 (gene)

GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene.

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GFRA3

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.

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GFRA4

GDNF family receptor alpha-4 (GFRα4), also known as the persephin receptor, is a protein that in humans is encoded by the GFRA4 gene.

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Glial cell line-derived neurotrophic factor

Glial cell-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene.

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Neurturin

Neurturin (NRTN) is a protein.

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Persephin

Persephin is a neurotrophic factor in the glial cell line-derived neurotrophic factor (GDNF) family.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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RET proto-oncogene

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules.

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Redirects here:

GDNF family receptor, GDNF family receptor alpha, GDNF family receptor-alpha, GDNF family receptor-α, GDNF receptor alpha, GDNF receptor-alpha, GDNF receptor-α, GFR alpha, GFR-alpha, GFR-α, GFRalpha.

References

[1] https://en.wikipedia.org/wiki/GFRα

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