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28 relations: Arachidonic acid, CD8+ cell, Chemotaxis, Chinese hamster ovary cell, Cyclic adenosine monophosphate, Docosahexaenoic acid, Epithelium, Formyl peptide receptor 1, Formyl peptide receptor 2, G protein–coupled receptor, Homology (biology), Inflammation, Ligand, Lipoxin, Lymphocyte, Macrophage, Molecular cloning, N-Formylmethionine-leucyl-phenylalanine, Neutrophil, Omega-3 fatty acid, Orphan receptor, Polyunsaturated fatty acid, Receptor (biochemistry), Resolvin, Rhodopsin-like receptors, Specialized pro-resolving mediators, T helper 17 cell, T helper cell.
Arachidonic acid
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
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CD8+ cell
CD8+ T cells (commonly known as cytotoxic T cells) are cells of the immune system that contribute to the body's adaptive immune response.
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Chemotaxis
Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.
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Chinese hamster ovary cell
Chinese hamster ovary (CHO) cells are an epithelial cell line derived from the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of therapeutic proteins.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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Docosahexaenoic acid
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina.
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Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
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Formyl peptide receptor 1
Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the formyl peptide receptor 1 (FPR1) gene.
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Formyl peptide receptor 2
N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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Lipoxin
Lipoxins (LXs or Lxs), an acronym for lipoxygenase interaction products, are bioactive autacoid metabolites of arachidonic acid made by various cell types.
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Lymphocyte
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Molecular cloning
Molecular cloning is a set of experimental methods in molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms.
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N-Formylmethionine-leucyl-phenylalanine
N-Formylmethionyl-leucyl-phenylalanine (FMLP) or N-formyl-met-leu-phe) is a N-formylated tripeptide and sometimes simply referred to as chemotactic peptide is a potent polymorphonuclear leukocyte (PMN) chemotactic factor and is also a macrophage activator. FMLP is the prototypical representative of the N-fomylated oligopeptide family of chemotactic factors. These oligopeptides are known to be, or mimic the actions of, the N-formyl oligopeptides that are (a) released by tissue bacteria, (b) attract and activate circulating blood leukocytes by binding to specific G protein coupled receptors on these cells, and (c) thereby direct the inflammatory response to sites of bacterial invasion. FMLP is involved in the innate immunity mechanism for host defense against pathogens. FMLP led to the first discovery of a leukocyte receptor for a chemotactic factor, defined three different types of FMLP receptors that have complimentary and/or opposing effects on inflammatory responses as well as many other activities, and helped define the stimulus-response coupling mechanisms by which diverse chemotactic factors and their G protein coupled receptors induce cellular function.
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Neutrophil
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
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Omega-3 fatty acid
Omega−3 fatty acids, also called ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs).
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Orphan receptor
In biochemistry, an orphan receptor is a protein that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified.
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Polyunsaturated fatty acid
Polyunsaturated fatty acids (PUFAs) are fatty acids that contain more than one double bond in their backbone.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Resolvin
Resolvins are metabolic byproducts of omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as docosapentaenoic acid (DPA) and clupanodonic acid.
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Rhodopsin-like receptors
Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors.
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Specialized pro-resolving mediators
Specialized pro-resolving mediators (SPM, also termed specialized proresolving mediators) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty acids (PUFA) by one or a combination of lipoxygenase, cyclooxygenase, and cytochrome P450 monooxygenase enzymes.
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T helper 17 cell
T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).
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T helper cell
The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.
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References
[1] https://en.wikipedia.org/wiki/GPR32
