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8 relations: Almorexant, Filorexant, GlaxoSmithKline, Insomnia, Lemborexant, Orexin receptor, Receptor antagonist, Suvorexant.
Almorexant
Almorexant (INN, codenamed ACT-078573) is an orexin antagonist, functioning as a competitive receptor antagonist of the OX1 and OX2 orexin receptors, which was being developed by the pharmaceutical companies Actelion and GSK for the treatment of insomnia.
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Filorexant
Filorexant (INN, USAN) (code name MK-6096) is an orexin antagonist which is or was under development by Merck for the treatment of insomnia.
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GlaxoSmithKline
GlaxoSmithKline plc (GSK) is a British pharmaceutical company headquartered in Brentford, London.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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Lemborexant
Lemborexant (code name E-2006) is a dual antagonist of the orexin OX1 and OX2 receptors which is under development by Eisai for the treatment of insomnia.
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Orexin receptor
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Suvorexant
Suvorexant, sold under the trade name Belsomra, is a medication for the treatment of insomnia.
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