74 relations: Agonist, AP-1 transcription factor, BAG1, C-terminus, CEBPB, Cell membrane, Cell nucleus, Central nervous system, Chromosome 5, Corticosteroid, Cortisol, CREB-binding protein, Cushing's disease, Cytoplasm, Cytosol, DAP3, Death-associated protein 6, Depression (mood), Developmental biology, Dexamethasone, DNA-binding domain, FKBP52, Gene, Gene expression, Glucocorticoid, Heat shock protein, Heat shock protein 90kDa alpha (cytosolic), member A1, HNRPU, Hormone response element, Hsp70, Hsp90, Immune system, Ketoconazole, MED1, MED14, Membrane glucocorticoid receptor, Metabolism, Mifepristone, Mineralocorticoid receptor, Mothers against decapentaplegic homolog 3, N-terminus, Neuroendocrine cell, NF-κB, Norepinephrine, NRIP1, Nuclear receptor, Nuclear receptor co-repressor 1, Nuclear receptor coactivator 1, Nuclear receptor coactivator 2, Nuclear receptor coactivator 3, ..., Pleiotropy, Posttraumatic stress disorder, POU2F1, Protein dimer, Protein–protein interaction, RANBP9, Receptor (biochemistry), Receptor antagonist, RELA, Selective glucocorticoid receptor modulator, Serotonin, SMARCA4, SMARCD1, STAT3, STAT5B, Steroid hormone receptor, Tacrolimus, Thioredoxin, Transactivation, Transcription (biology), Transcription factor, Transrepression, TRIM28, YWHAH. Expand index (24 more) » « Shrink index
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
Chromosome 5 is one of the 23 pairs of chromosomes in humans.
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.
Cortisol is a steroid hormone, in the glucocorticoid class of hormones.
CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.
Cushing's disease is a cause of Cushing's syndrome characterised by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism).
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.
28S ribosomal protein S29, mitochondrial, also known as death-associated protein 3 (DAP3), is a protein that in humans is encoded by the DAP3 gene on chromosome 1.
Death-associated protein 6 also known as Daxx is a protein that in humans is encoded by the DAXX gene.
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.
Developmental biology is the study of the process by which animals and plants grow and develop.
Dexamethasone is a type of corticosteroid medication.
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.
FK506-binding protein 4 is a protein that in humans is encoded by the FKBP4 gene.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene.
Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene.
A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene that is able to bind to a specific hormone receptor complex and therefore regulate transcription.
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins.
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation.
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
Ketoconazole is a synthetic imidazole antifungal drug used primarily to treat fungal infections.
Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene.
Mediator of RNA polymerase II transcription subunit 14 is an enzyme that in humans is encoded by the MED14 gene.
Membrane glucocorticoid receptors (mGRs) are a group of receptors which bind and are activated by glucocorticoids such as cortisol and corticosterone, as well as certain exogenous glucocorticoids such as dexamethasone.
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol, to bring about an abortion.
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene.
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
Neuroendocrine cells are cells that receive neuronal input (neurotransmitters released by nerve cells or neurosecretory cells) and, as a consequence of this input, release message molecules (hormones) to the blood.
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
Nuclear receptor-interacting protein 1 (NRIP1) also known as receptor-interacting protein 140 (RIP140) is a protein that in humans is encoded by the NRIP1 gene.
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.
The nuclear receptor coactivator 1 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity.
The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene.
The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.
Pleiotropy (from Greek πλείων pleion, "more", and τρόπος tropos, "way") occurs when one gene influences two or more seemingly unrelated phenotypic traits.
Posttraumatic stress disorder (PTSD)Acceptable variants of this term exist; see the Terminology section in this article.
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.
Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor agonists (DIGRAs) are a class of experimental drugs designed to share many of the desirable anti-inflammatory, immunosuppressive, or anticancer properties of classical glucocorticoid drugs but with fewer side effects such as skin atrophy.
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 is a protein that in humans is encoded by the SMARCD1 gene.
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene.
Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.
Steroid hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells.
Thioredoxin is a class of small redox proteins known to be present in all organisms.
In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
In the field of molecular biology, transrepression is a process whereby one protein represses (i.e., inhibits) the activity of a second protein through a protein-protein interaction.
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene.
14-3-3 protein eta is a protein that in humans is encoded by the YWHAH gene.