28 relations: Antigen, Broadly neutralizing HIV-1 antibodies, CCR5, CD4+ T cells and antitumor immunity, CXCR4, Disulfide, Ectodomain, Enfuvirtide, Entry inhibitor, Env (gene), Envelope glycoprotein GP120, Furin, Glycosylation, Heptad repeat, HIV, Macrophage, Membrane fusion protein, Metastability, Non-covalent interactions, Peptide, Protease, Protein complex, Proteolysis, Retrovirus, T helper cell, Torus, Transmembrane protein, Virus.
Antigen
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.
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Broadly neutralizing HIV-1 antibodies
Broadly Neutralizing HIV-1 Antibodies (bNAbs) are neutralizing antibodies which neutralize multiple HIV-1 viral strains.
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CCR5
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
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CD4+ T cells and antitumor immunity
Understanding of the antitumor immunity role of CD4+ T cells has grown substantially since the late 1990s.
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CXCR4
C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene.
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Disulfide
In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.
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Ectodomain
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell).
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Enfuvirtide
Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.
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Entry inhibitor
Entry inhibitors, also known as fusion inhibitors, are a class of antiretroviral drugs, used in combination therapy for the treatment of HIV infection.
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Env (gene)
Env is a viral gene that encodes the protein forming the viral envelope.
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Envelope glycoprotein GP120
Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope.
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Furin
Furin is a protein that in humans is encoded by the FURIN gene.
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Glycosylation
Glycosylation (see also chemical glycosylation) is the reaction in which a carbohydrate, i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor).
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Heptad repeat
The heptad repeat is an example of a structural motif that consists of a repeating pattern of seven amino acids: where H represents hydrophobic residues, C represents, typically, charged residues, and P represents polar (and, therefore, hydrophilic) residues.
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HIV
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Membrane fusion protein
Membrane fusion proteins (not to be confused with chimeric or fusion proteins) are proteins that cause fusion of biological membranes.
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Metastability
In physics, metastability is a stable state of a dynamical system other than the system's state of least energy.
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Non-covalent interactions
A non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Protease
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
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Protein complex
A protein complex or multiprotein complex is a group of two or more associated polypeptide chains.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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Retrovirus
A retrovirus is a single-stranded positive-sense RNA virus with a DNA intermediate and, as an obligate parasite, targets a host cell.
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T helper cell
The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.
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Torus
In geometry, a torus (plural tori) is a surface of revolution generated by revolving a circle in three-dimensional space about an axis coplanar with the circle.
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Transmembrane protein
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.
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Virus
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
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References
[1] https://en.wikipedia.org/wiki/Gp41