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37 relations: Active site, Amprenavir, Aspartic acid, Atazanavir, Ångström, Catalytic triad, Darunavir, Discovery and development of HIV-protease inhibitors, Drug resistance, Food and Drug Administration, Fosamprenavir, Glycine, Group-specific antigen, HIV, HIV/AIDS, Indinavir, Integrase, Lopinavir, Management of HIV/AIDS, MEROPS, Mutation rate, Nelfinavir, Peptide, Pol (HIV), Protease inhibitor (pharmacology), Protein dimer, Proteolysis, Retroviral aspartyl protease, Retrovirus, Reverse transcriptase, Ritonavir, Saquinavir, Scissile bond, Substrate (chemistry), Threonine, Tipranavir, Virus.
Active site
In biology, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.
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Amprenavir
Amprenavir (original brand name Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection.
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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Atazanavir
Atazanavir, sold under the trade name Reyataz among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
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Ångström
The ångström or angstrom is a unit of length equal to (one ten-billionth of a metre) or 0.1 nanometre.
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Catalytic triad
A catalytic triad is a set of three coordinated amino acids that can be found in the active site of some enzymes.
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Darunavir
Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
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Discovery and development of HIV-protease inhibitors
Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed.
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Drug resistance
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a disease or condition.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Fosamprenavir
Fosamprenavir (marketed by ViiV Healthcare as the calcium salt under the trade names Lexiva in the U.S. and Telzir in Europe) is a drug for the treatment of HIV infections.
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Glycine
Glycine (symbol Gly or G) is the amino acid that has a single hydrogen atom as its side chain.
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Group-specific antigen
Group-specific antigen, or gag, is the genetic material that codes for the core structural proteins of a retrovirus.
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HIV
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
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HIV/AIDS
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).
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Indinavir
Indinavir (IDV; trade name Crixivan, manufactured by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.
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Integrase
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
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Lopinavir
Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class.
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Management of HIV/AIDS
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection.
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MEROPS
MEROPS is an on-line database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors.
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Mutation rate
In genetics, the mutation rate is the frequency of new mutations in a single gene or organism over time.
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Nelfinavir
Nelfinavir (brand name Viracept) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV).
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Pol (HIV)
Pol (DNA ymerase) refers to a gene in retroviruses, or the protein produced by that gene.
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Protease inhibitor (pharmacology)
Protease inhibitors (PIs) are a class of antiviral drugs that are widely used to treat HIV/AIDS and hepatitis C. Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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Retroviral aspartyl protease
Retroviral aspartyl proteases are single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses).
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Retrovirus
A retrovirus is a single-stranded positive-sense RNA virus with a DNA intermediate and, as an obligate parasite, targets a host cell.
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Reverse transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.
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Ritonavir
Ritonavir, sold under the trade name Norvir, is an antiretroviral medication used along with other medications to treat HIV/AIDS.
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Saquinavir
Saquinavir, sold under the brand names Invirase and Fortovase, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS.
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Scissile bond
In molecular biology, a scissile bond is a covalent chemical bond that can be broken by an enzyme.
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Substrate (chemistry)
In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.
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Threonine
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.
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Tipranavir
Tipranavir (TPV), or tipranavir disodium, is a nonpeptidic protease inhibitor (PI) manufactured by Boehringer Ingelheim under the trade name Aptivus.
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Virus
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
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Redirects here:
EC 3.4.23.16, Gag protease, HIV aspartyl protease, HIV protease, HIV proteinase, HIV-1 PR, HIV-1 retropepsin, HIV-2 protease, Hiv protease, Hiv-1 protease, Human immunodeficiency virus type 1 protease, Retroproteinase.
References
[1] https://en.wikipedia.org/wiki/HIV-1_protease
