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Hematopoietic stem cell transplantation

Index Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. [1]

145 relations: Aciclovir, Acta Oncologica, Acute lymphoblastic leukemia, Acute myeloid leukemia, Allele, Allotransplantation, Amniotic fluid, Antibiotic, Anticoagulant, Antiviral drug, Apheresis, Aplastic anemia, Autoimmune disease, Autologous stem-cell transplantation, Base pair, BBC News, Belfast Telegraph, Bile, Bilirubin, Blood, Blood (journal), Blood cell, Bone marrow, Bone Marrow Donors Worldwide, Bone Marrow Transplantation (journal), British Journal of Haematology, Cancer, CCR5, Chemotherapy, Childbirth, Chimera (genetics), Chronic granulomatous disease, Chronic myelogenous leukemia, Cord blood, Cord blood bank, Corticosteroid, Criticality accident, Cyclophosphamide, Defibrotide, Desmoplastic small-round-cell tumor, Diabetes mellitus type 1, Dimethyl sulfoxide, DNA, Donor lymphocyte infusion, E. Donnall Thomas, Ethnic group, Ewing's sarcoma, Fanconi anemia, Fibrosis, Filgrastim, ..., Fred Hutchinson Cancer Research Center, Gastrointestinal tract, General anaesthesia, Georges Mathé, Gero Hütter, Glioma, Graft-versus-host disease, Graft-versus-tumor effect, Granulocyte colony-stimulating factor, Haematologica, Heart, Hematopoietic stem cell, Hepatic veno-occlusive disease, Hepatomegaly, Herpes simplex, HIV, HLA-DQB1, Hodgkin's lymphoma, Human leukocyte antigen, Hypodermic needle, Immune system, Immunosuppression, Immunosuppressive drug, Infection, Irradiation, Lenograstim, Leukemia, Leukoencephalopathy, Liquid nitrogen, Liver, Locus (genetics), Lymphoma, Major histocompatibility complex, Malignant infantile osteopetrosis, Management of HIV/AIDS, Measles, Medication, Microtransplantation, Mouth, Mucopolysaccharidosis, Mucositis, Multiple myeloma, Multiple sclerosis, Muscle, Myelodysplastic syndrome, National Marrow Donor Program, Neoplasm, Neuroblastoma, Neutropenia, Nigeria, Nobel Prize in Physiology or Medicine, Non-Hodgkin lymphoma, Opportunistic infection, Oral cancer, Osmosis, Osteochondrodysplasia, Pediatrics, Pelvis, Placenta, Poliomyelitis, Prednisone, Preimplantation genetic diagnosis, Preventive healthcare, Prochymal, Race (human categorization), Radiation, Radiation therapy, Red blood cell, Robert A. Good, Roentgen equivalent man, Savior sibling, Scleroderma, Sepsis, Septic shock, Serostatus, Severe combined immunodeficiency, Sickle cell disease, Skin, Splenic injury, Squamous cell carcinoma, Stem cell, T cell, Thalassemia, Timothy Ray Brown, Total body irradiation, Transplant rejection, Twin, Umbilical cord, University of Minnesota, Ursodeoxycholic acid, Vaccine, Valaciclovir, Vinča Nuclear Institute, White blood cell, Wiskott–Aldrich syndrome. Expand index (95 more) »

Aciclovir

Aciclovir (ACV), also known as acyclovir, is an antiviral medication.

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Acta Oncologica

Acta Oncologica is a peer-reviewed medical journal of oncology and the official journal of the five Nordic oncological societies.

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Acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.

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Acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.

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Allele

An allele is a variant form of a given gene.

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Allotransplantation

Allotransplant (allo- meaning "other" in Greek) is the transplantation of cells, tissues, or organs, to a recipient from a genetically non-identical donor of the same species.

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Amniotic fluid

The amniotic fluid is the protective liquid contained by the amniotic sac of a gravid Amniote.

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Antibiotic

An antibiotic (from ancient Greek αντιβιοτικά, antibiotiká), also called an antibacterial, is a type of antimicrobial drug used in the treatment and prevention of bacterial infections.

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Anticoagulant

Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.

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Antiviral drug

Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones.

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Apheresis

Apheresis (ἀφαίρεσις (aphairesis, "a taking away")) is a medical technology in which the blood of a person is passed through an apparatus that separates out one particular constituent and returns the remainder to the circulation.The blood is filtered to remove the stem cells.

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Aplastic anemia

Aplastic anaemia is a rare disease in which the bone marrow and the hematopoietic stem cells that reside there are damaged.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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Autologous stem-cell transplantation

Autologous stem-cell transplantation (also called autogenous, autogeneic, or autogenic stem-cell transplantation and abbreviated auto-SCT) is autologous transplantation of stem cells—that is, transplantation in which stem cells (undifferentiated cells from which other cell types develop) are removed from a person, stored, and later given back to that same person.

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Base pair

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.

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BBC News

BBC News is an operational business division of the British Broadcasting Corporation (BBC) responsible for the gathering and broadcasting of news and current affairs.

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Belfast Telegraph

The Belfast Telegraph is a daily newspaper published in Belfast, Northern Ireland, by Independent News & Media.

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Bile

Bile or gall is a dark green to yellowish brown fluid, produced by the liver of most vertebrates, that aids the digestion of lipids in the small intestine.

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Bilirubin

Bilirubin is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.

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Blood

Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.

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Blood (journal)

Blood is a peer-reviewed medical journal published by the American Society of Hematology.

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Blood cell

A blood cell, also called a haematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found mainly in the blood.

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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Bone Marrow Donors Worldwide

Bone Marrow Donors Worldwide (BMDW) is an organization based in Leiden, Netherlands, that coordinates the collection of the HLA phenotypes and other relevant data of volunteer hematopoietic cell donors (used to perform what used to be called bone marrow transplants, but now referred as hematopoietic cell transplants) and cord blood units across the globe.

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Bone Marrow Transplantation (journal)

Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans.

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British Journal of Haematology

The British Journal of Haematology is a peer-reviewed medical journal focusing on hematology and other blood-related topics, such as blood diseases and their treatment.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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CCR5

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Childbirth

Childbirth, also known as labour and delivery, is the ending of a pregnancy by one or more babies leaving a woman's uterus by vaginal passage or C-section.

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Chimera (genetics)

A genetic chimerism or chimera (also spelled chimaera) is a single organism composed of cells with distinct genotypes.

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Chronic granulomatous disease

Chronic granulomatous disease (CGD) (also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens.

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Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.

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Cord blood

Umbilical cord blood is blood that remains in the placenta and in the attached umbilical cord after childbirth.

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Cord blood bank

A cord blood bank is a facility which stores umbilical cord blood for future use.

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Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.

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Criticality accident

A criticality accident is an uncontrolled nuclear fission chain reaction.

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Cyclophosphamide

Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.

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Defibrotide

Defibrotide, sold under the brandname Defitelio, is a mixture of single-stranded oligonucleotides that is purified from the intestinal mucosa of pigs.

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Desmoplastic small-round-cell tumor

Desmoplastic small-round-cell tumor is an aggressive and rare cancer that primarily occurs as masses in the abdomen.

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Diabetes mellitus type 1

Diabetes mellitus type 1, also known as type 1 diabetes, is a form of diabetes mellitus in which not enough insulin is produced.

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Dimethyl sulfoxide

Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Donor lymphocyte infusion

Donor lymphocyte (or leukocyte) infusion (DLI) or buffy coat infusion is a form of adoptive immunotherapy used after hematopoietic stem cell transplantation.

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E. Donnall Thomas

Edward Donnall "Don" Thomas (March 15, 1920 – October 20, 2012)Frederick R. Appelbaum.

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Ethnic group

An ethnic group, or an ethnicity, is a category of people who identify with each other based on similarities such as common ancestry, language, history, society, culture or nation.

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Ewing's sarcoma

Ewing's sarcoma or Ewing sarcoma is a malignant small, round, blue cell tumor.

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Fanconi anemia

Fanconi anaemia (FA) is a rare genetic disease resulting in impaired response to DNA damage.

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Fibrosis

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.

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Filgrastim

Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low blood neutrophils.

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Fred Hutchinson Cancer Research Center

The Fred Hutchinson Cancer Research Center, also known as Fred Hutch or The Hutch, is a cancer research institute established in 1972 in Seattle, Washington.

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Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

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General anaesthesia

General anaesthesia or general anesthesia (see spelling differences) is a medically induced coma with loss of protective reflexes, resulting from the administration of one or more general anaesthetic agents.

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Georges Mathé

Georges Mathé (9 July 1922 – 15 October 2010) was a French oncologist and immunologist.

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Gero Hütter

Gero Hütter (born 18 December 1968) is a German hematologist.

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Glioma

A glioma is a type of tumor that starts in the glial cells of the brain or the spine.

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Graft-versus-host disease

Graft-versus-host disease (GvHD) is a medical complication following the receipt of transplanted tissue from a genetically different person.

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Graft-versus-tumor effect

Graft-versus-tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT).

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Granulocyte colony-stimulating factor

Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.

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Haematologica

Haematologica (Pavia, Italy) is a monthly, open access, peer reviewed, scientific journal, published by the Ferrata Storti Foundation.

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Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

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Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.

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Hepatic veno-occlusive disease

Hepatic veno-occlusive disease or veno-occlusive disease with immunodeficiency (VODI) is a condition in which some of the small veins in the liver are obstructed.

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Hepatomegaly

Hepatomegaly is the condition of having an enlarged liver.

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Herpes simplex

Herpes simplex is a viral disease caused by the herpes simplex virus.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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HLA-DQB1

Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene.

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Hodgkin's lymphoma

Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.

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Human leukocyte antigen

The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans.

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Hypodermic needle

Hypodermic needle features A hypodermic needle (from Greek ὑπο- (under-), and δέρμα (skin)), one of a category of medical tools which enter the skin, called sharps, is a very thin, hollow tube with a sharp tip that contains a small opening at the pointed end.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Immunosuppression

Immunosuppression is a reduction of the activation or efficacy of the immune system.

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Immunosuppressive drug

Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system.

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Infection

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.

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Irradiation

Irradiation is the process by which an object is exposed to radiation.

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Lenograstim

Lenograstim is a recombinant granulocyte colony-stimulating factor which functions as an immunostimulator.

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Leukemia

Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.

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Leukoencephalopathy

The term leukoencephalopathy is a broad term for leukodystrophy-like diseases.

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Liquid nitrogen

Liquid nitrogen is nitrogen in a liquid state at an extremely low temperature.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Major histocompatibility complex

The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility.

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Malignant infantile osteopetrosis

Malignant infantile osteopetrosis, also known as infantile autosomal recessive osteopetrosis or simply infantile osteopetrosis is a rare osteosclerosing type of skeletal dysplasia that typically presents in infancy and is characterized by a unique radiographic appearance of generalized hyperostosis - excessive growth of bone.

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Management of HIV/AIDS

The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection.

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Measles

Measles is a highly contagious infectious disease caused by the measles virus.

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Medication

A medication (also referred to as medicine, pharmaceutical drug, or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.

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Microtransplantation

Microtransplantation(MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy.

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Mouth

In animal anatomy, the mouth, also known as the oral cavity, buccal cavity, or in Latin cavum oris, is the opening through which many animals take in food and issue vocal sounds.

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Mucopolysaccharidosis

Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes needed to break down molecules called glycosaminoglycans.

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Mucositis

Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer.

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Multiple myeloma

Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies.

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Multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

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Muscle

Muscle is a soft tissue found in most animals.

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Myelodysplastic syndrome

Myelodysplastic syndromes (MDS) are a group of cancers in which immature blood cells in the bone marrow do not mature and therefore do not become healthy blood cells.

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National Marrow Donor Program

The National Marrow Donor Program (NMDP) is a nonprofit organization founded in 1986 and based in Minneapolis, Minnesota that operates the Be The Match Registry of volunteer hematopoietic cell donors and umbilical cord blood units in the United States.

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Neoplasm

Neoplasia is a type of abnormal and excessive growth of tissue.

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Neuroblastoma

Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands, but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Occasionally, neuroblastoma may be due to a mutation inherited from a person's parents. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiation, chemotherapy, or stem cell transplantation. Low-risk disease in babies typically has a good outcome with surgery or simply observation. In high-risk disease, chances of long-term survival, however, are less than 40% despite aggressive treatment. Neuroblastoma is the most common cancer in babies and the third-most common cancer in children after leukemia and brain cancer. About one in every 7,000 children is affected at some time. About 90% of cases occur in children less than 5 years old and it is rare in adults. Of cancer deaths in children, about 15% are due to neuroblastoma. The disease was first described in the 1800s.

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Neutropenia

Neutropenia or neutropaenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood.

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Nigeria

Nigeria, officially the Federal Republic of Nigeria is a federal republic in West Africa, bordering Benin in the west, Chad and Cameroon in the east, and Niger in the north.

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Nobel Prize in Physiology or Medicine

The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin), administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the fields of life sciences and medicine.

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Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.

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Opportunistic infection

An opportunistic infection is an infection caused by pathogens (bacteria, viruses, fungi, or protozoa) that take advantage of an opportunity not normally available, such as a host with a weakened immune system, an altered microbiota (such as a disrupted gut microbiota), or breached integumentary barriers.

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Oral cancer

Oral cancer, also known as mouth cancer, is a type of head and neck cancer and is any cancerous tissue growth located in the oral cavity.

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Osmosis

Osmosis is the spontaneous net movement of solvent molecules through a selectively permeable membrane into a region of higher solute concentration, in the direction that tends to equalize the solute concentrations on the two sides.

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Osteochondrodysplasia

Osteochondrodysplasia or skeletal dysplasia is a general term for a disorder of the development (dysplasia) of bone ("osteo") and cartilage ("chondro").

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Pediatrics

Pediatrics (also spelled paediatrics or pædiatrics) is the branch of medicine that involves the medical care of infants, children, and adolescents.

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Pelvis

The pelvis (plural pelves or pelvises) is either the lower part of the trunk of the human body between the abdomen and the thighs (sometimes also called pelvic region of the trunk) or the skeleton embedded in it (sometimes also called bony pelvis, or pelvic skeleton).

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Placenta

The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.

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Poliomyelitis

Poliomyelitis, often called polio or infantile paralysis, is an infectious disease caused by the poliovirus.

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Prednisone

Prednisone is a synthetic glucocorticoid drug that is mostly used to suppress the immune system.

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Preimplantation genetic diagnosis

Pre-implantation genetic diagnosis (PGD or PIGD) is the genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization.

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Preventive healthcare

Preventive healthcare (alternately preventive medicine, preventative healthcare/medicine, or prophylaxis) consists of measures taken for disease prevention, as opposed to disease treatment.

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Prochymal

Prochymal is a stem cell therapy made by Osiris Therapeutics.

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Race (human categorization)

A race is a grouping of humans based on shared physical or social qualities into categories generally viewed as distinct by society.

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Radiation

In physics, radiation is the emission or transmission of energy in the form of waves or particles through space or through a material medium.

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Radiation therapy

Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Robert A. Good

Robert Alan Good (May 21, 1922 – June 13, 2003) was an American physician who performed the first successful human bone marrow transplant between persons who were not identical twins and is regarded as a founder of modern immunology.

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Roentgen equivalent man

The roentgen equivalent man (or rem) is an older, CGS unit of equivalent dose, effective dose, and committed dose which are measures of the health effect of low levels of ionizing radiation on the human body.

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Savior sibling

A savior baby or savior sibling is a child who is born to provide an organ or cell transplant to a sibling that is affected with a fatal disease, such as cancer or Fanconi anemia, that can best be treated by hematopoietic stem cell transplantation.

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Scleroderma

Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs.

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Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

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Septic shock

Septic shock is a serious medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

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Serostatus

Serostatus refers to the presence or absence of a serological marker in the blood.

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Severe combined immunodeficiency

Severe combined immunodeficiency, SCID, also known as alymphocytosis, Glanzmann–Riniker syndrome, severe mixed immunodeficiency syndrome, and thymic alymphoplasia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in heterogeneous clinical presentations.

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Sickle cell disease

Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents.

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Skin

Skin is the soft outer tissue covering vertebrates.

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Splenic injury

A splenic injury, which includes a ruptured spleen, is any injury to the spleen.

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Squamous cell carcinoma

Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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Thalassemia

Thalassemias are inherited blood disorders characterized by abnormal hemoglobin production.

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Timothy Ray Brown

Timothy Ray Brown (born 1966) is an American considered to be the first person cured of HIV/AIDS.

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Total body irradiation

Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation.

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Transplant rejection

Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue.

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Twin

Twins are two offspring produced by the same pregnancy.

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Umbilical cord

In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta.

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University of Minnesota

The University of Minnesota, Twin Cities (often referred to as the University of Minnesota, Minnesota, the U of M, UMN, or simply the U) is a public research university in Minneapolis and Saint Paul, Minnesota.

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Ursodeoxycholic acid

Ursodeoxycholic acid (INN, BAN and AAN), also known as ursodiol (USAN) and the abbreviation UDCA, from the root-word for bear urso, as bear bile contains the substance, is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria.

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Vaccine

A vaccine is a biological preparation that provides active acquired immunity to a particular disease.

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Valaciclovir

Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir.

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Vinča Nuclear Institute

The Vinča Institute of Nuclear Sciences is a nuclear physics research institution near Belgrade, Serbia.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Wiskott–Aldrich syndrome

Wiskott–Aldrich syndrome (WAS) is a rare X-linked recessive disease characterized by eczema, thrombocytopenia (low platelet count), immune deficiency, and bloody diarrhea (secondary to the thrombocytopenia).

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References

[1] https://en.wikipedia.org/wiki/Hematopoietic_stem_cell_transplantation

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