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Hemolytic-uremic syndrome

Index Hemolytic-uremic syndrome

Hemolytic-uremic syndrome (HUS) is a disease characterized by a triad of hemolytic anemia (anemia caused by destruction of red blood cells), acute kidney failure (uremia), and a low platelet count (thrombocytopenia). [1]

84 relations: Acute kidney injury, ADAMTS13, Alexion Pharmaceuticals, Apoptosis, Arteriole, Atypical hemolytic uremic syndrome, Blood transfusion, Campylobacter, Capillary, Central nervous system, Chemokine, Chronic kidney disease, Coagulation, Coagulation screen, Complement system, Cytokine, Dialysis, Diarrhea, Disseminated intravascular coagulation, Eculizumab, Edema, Encephalopathy, Endothelium, Escherichia coli, Escherichia coli O157:H7, Fabry disease, Fenugreek, Fibrin degradation product, Fibrinogen, Foodborne illness, Germany, Globotriaosylceramide, Glomerulus, Hematuria, Hemodialysis, Hemoglobin, Hemolysis, Hemolytic anemia, Histology, Hyperplasia, Hypertension, Inflammation, International nonproprietary name, Ischemia, Kidney, Kidney failure, Lactate dehydrogenase, Medical emergency, Mesangium, Metalloproteinase, ..., Microangiopathic hemolytic anemia, Microangiopathy, Microvessel, Monoclonal antibody, Nephrology, Oliguria, Pancreatitis, Paroxysmal nocturnal hemoglobinuria, Plasmapheresis, Platelet, Prodrome, Quinolone, Red blood cell, Renal cortical necrosis, Schistocyte, Sepsis, Shiga toxin, Shiga-like toxin, Shigatoxigenic and verotoxigenic Escherichia coli, Shigella, Shigella dysenteriae, Shigellosis, Syndrome, The New England Journal of Medicine, Thrombocytopenia, Thrombogenicity, Thrombotic microangiopathy, Thrombotic thrombocytopenic purpura, Toxin (novel), Union of South American Nations, Uremia, Virus, Von Willebrand factor, White blood cell. Expand index (34 more) »

Acute kidney injury

Acute kidney injury (AKI), previously called acute renal failure (ARF), is an abrupt loss of kidney function that develops within 7 days.

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ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13)—also known as von Willebrand factor-cleaving protease (VWFCP)—is a zinc-containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large protein involved in blood clotting.

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Alexion Pharmaceuticals

Alexion Pharmaceuticals Inc. is an American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH).

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Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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An arteriole is a small-diameter blood vessel in the microcirculation that extends and branches out from an artery and leads to capillaries.

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Atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome (aHUS) is an extremely rare, life-threatening, progressive disease that frequently has a genetic component.

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Blood transfusion

Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously.

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Campylobacter (meaning "curved bacteria") is a genus of Gram-negative bacteria.

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A capillary is a small blood vessel from 5 to 10 micrometres (µm) in diameter, and having a wall one endothelial cell thick.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.

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Chronic kidney disease

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months or years.

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Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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Coagulation screen

A coagulation screen is a combination of screening laboratory tests, designed to provide rapid non-specific information, which allows an initial broad categorization of haemostatic problems.

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Complement system

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane.

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Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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In medicine, dialysis (from Greek διάλυσις, diàlysis, "dissolution"; from διά, dià, "through", and λύσις, lỳsis, "loosening or splitting") is the process of removing excess water, solutes and toxins from the blood in those whose native kidneys have lost the ability to perform these functions in a natural way.

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Diarrhea, also spelled diarrhoea, is the condition of having at least three loose or liquid bowel movements each day.

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Disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels.

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Eculizumab, sold under the trade name Soliris, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

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Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.

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Encephalopathy (from ἐγκέφαλος "brain" + πάθος "suffering") means any disorder or disease of the brain, especially chronic degenerative conditions.

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Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Escherichia coli O157:H7

Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga toxin–producing types of E. coli.

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Fabry disease

Fabry disease is a rare genetic disease.

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Fenugreek (Trigonella foenum-graecum) is an annual plant in the family Fabaceae, with leaves consisting of three small obovate to oblong leaflets.

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Fibrin degradation product

Fibrin degradation products (FDPs), also known as fibrin split products, are components of the blood produced by clot degeneration.

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Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood.

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Foodborne illness

Foodborne illness (also foodborne disease and colloquially referred to as food poisoning) is any illness resulting from the food spoilage of contaminated food, pathogenic bacteria, viruses, or parasites that contaminate food, as well as toxins such as poisonous mushrooms and various species of beans that have not been boiled for at least 10 minutes.

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Germany (Deutschland), officially the Federal Republic of Germany (Bundesrepublik Deutschland), is a sovereign state in central-western Europe.

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Globotriaosylceramide is a globoside.

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Glomerulus is a common term used in anatomy to describe globular structures of entwined vessels, fibers, or neurons.

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Hematuria is the presence of red blood cells in the urine.

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Hemodialysis, also spelled haemodialysis, commonly called kidney dialysis or simply dialysis, is a process of purifying the blood of a person whose kidneys are not working normally.

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Hemoglobin (American) or haemoglobin (British); abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (with the exception of the fish family Channichthyidae) as well as the tissues of some invertebrates.

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Hemolysis or haemolysis, also known by several other names, is the rupturing (lysis) of red blood cells (erythrocytes) and the release of their contents (cytoplasm) into surrounding fluid (e.g. blood plasma).

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Hemolytic anemia

Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood vessels (intravascular hemolysis) or elsewhere in the human body (extravascular, but usually in the spleen).

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Histology, also microanatomy, is the study of the anatomy of cells and tissues of plants and animals using microscopy.

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Hyperplasia (from ancient Greek ὑπέρ huper, "over" + πλάσις plasis, "formation"), or hypergenesis, is an increase in the amount of organic tissue that results from cell proliferation.

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Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).

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The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Kidney failure

Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys no longer work.

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Lactate dehydrogenase

Lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells (animals, plants, and prokaryotes).

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Medical emergency

A medical emergency is an acute injury or illness that poses an immediate risk to a person's life or long-term health.

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In the glomerulus of the kidney, the mesangium is a structure associated with the capillaries.

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A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal.

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Microangiopathic hemolytic anemia

In medicine (hematology), microangiopathic hemolytic anemia (MAHA) is a microangiopathic subgroup of hemolytic anemia (loss of red blood cells through destruction) caused by factors in the small blood vessels.

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Microangiopathy (or microvascular disease, or small vessel disease) is an angiopathy (i.e. disease of blood vessels) affecting small blood vessels in the body.

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Microvessel or microvasculature refers to the smallest systems of blood vessels in a body, including those responsible for microcirculation, the system of smaller blood vessels that distribute blood within tissues.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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Nephrology (from Greek nephros "kidney", combined with the suffix -logy, "the study of") is a specialty of medicine and pediatrics that concerns itself with the kidneys: the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease, from diet and medication to renal replacement therapy (dialysis and kidney transplantation).

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Oliguria or hypouresis (both names from roots meaning "not enough urine") is the low output of urine.

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Pancreatitis is inflammation of the pancreas.

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Paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, life-threatening disease of the blood characterized by destruction of red blood cells by the complement system, a part of the body's innate immune system.

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Plasmapheresis (from the Greek πλάσμα—plasma, something molded, and ἀφαίρεσις—aphairesis, taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation.

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Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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In medicine, a prodrome is an early sign or symptom (or set of signs and symptoms), which often indicate the onset of a disease before more diagnostically specific signs and symptoms develop.

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Quinolone may refer to.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Renal cortical necrosis

Renal cortical necrosis (RCN) is a rare cause of acute kidney failure.

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A schistocyte or schizocyte (from Greek schistos for "divided" or schistein for "to split", and kytos for "hollow" or "cell") is a fragmented part of a red blood cell.

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Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

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Shiga toxin

Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages.

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Shiga-like toxin

Shiga-like toxin, also known as verotoxin and verocytotoxin, is a toxin generated by some strains of Escherichia coli (but see below).

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Shigatoxigenic and verotoxigenic Escherichia coli

Shigatoxigenic Escherichia coli (STEC) and verotoxigenic E. coli (VTEC) are strains of the bacterium Escherichia coli that produce either Shiga toxin or Shiga-like toxin (verotoxin).

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Shigella is a genus of gram-negative, facultative anaerobic, nonspore-forming, non-motile, rod-shaped bacteria genetically closely related to E. coli.

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Shigella dysenteriae

Shigella dysenteriae is a species of the rod-shaped bacterial genus Shigella.

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Shigellosis is a type of diarrhea caused by a bacterial infection with Shigella.

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A syndrome is a set of medical signs and symptoms that are correlated with each other and, often, with a particular disease or disorder.

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The New England Journal of Medicine

The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society.

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Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.

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Thrombogenicity refers to the tendency of a material in contact with the blood to produce a thrombus, or clot.

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Thrombotic microangiopathy

Thrombotic microangiopathy (TMA) is a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury.

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Thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body, resulting in low platelet counts.

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Toxin (novel)

Toxin is a 1998 suspense thriller written by Robin Cook.

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Union of South American Nations

The Union of South American Nations (USAN; Unión de Naciones Suramericanas, UNASUR; União de Nações Sul-Americanas, UNASUL; Unie van Zuid-Amerikaanse Naties, UZAN; and sometimes referred to as the South American Union) is an intergovernmental regional organization comprising twelve South American countries.

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Uremia is the condition of having "urea in the blood".

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A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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Von Willebrand factor

Von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Familial HUS, Familial Hemolytic uremic syndrome, Familial Hemolytic-uremic syndrome, Haemolytic uraemic syndrome, Haemolytic uremic syndrome, Haemolytic-uraemic syndrome, Haemolytic-uremic syndrome, Hemolytic Uremic Syndrome, Hemolytic uremic syndrome, Hemolytic-uremic disease, Typical haemolytic uraemic syndrome, Typical haemolytic-uraemic syndrome.


[1] https://en.wikipedia.org/wiki/Hemolytic-uremic_syndrome

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