114 relations: Aciclovir, Alkali, Allele, Alphaherpesvirinae, Alzheimer's disease, Amgen, Amino acid, Antigen presentation, Antiviral drug, Apolipoprotein E, Atherosclerosis, Autophagy, Axon, Blister, Capsid, Cell (biology), Cell nucleus, Cell surface receptor, Clade, Coagulation, Concatemer, Crossover study, Cytoplasm, DNA, DNA polymerase, DNA replication, DNA virus, DUTP diphosphatase, Early protein, Endocytosis, Endosome, Enzyme, Exonuclease, Flow cytometry, Ganglion, Gene expression, Genome, Glycoprotein, Glycosaminoglycan, Helicase–primase complex, Heparan sulfate, Herpes labialis, Herpes simplex, Herpes simplex research, Herpesviral encephalitis, Herpesvirales, Herpesviridae, Herpesvirus entry mediator, Herpesvirus glycoprotein B, Herpetic whitlow, ..., HHV capsid portal protein, HHV Infected Cell Polypeptide 0, HHV Latency Associated Transcript, Histology, Histone, Human, Icosahedron, Immediate early gene, Immune system, Infected cell protein 47, Infection, Interferon, Kaposi's sarcoma-associated herpesvirus, Kiss, Leucine zipper, Lipid bilayer, Lipoprotein, Lytic cycle, Messenger RNA, Methyl methanesulfonate, MHC class I, Micrograph, Mollaret's meningitis, Most recent common ancestor, Mucous membrane, Nectin, Neuron, Neurotropic virus, Oncolytic virus, Open reading frame, Oral sex, Origin of replication, Pathogen, Protein kinase, Protein kinase R, RE1-silencing transcription factor, Regular icosahedron, Ribonucleotide reductase, RNA, RNA polymerase II, Sacral ganglia, Serine, Simplexvirus, Skin, Stimulator of interferon genes, Threonine, Thymidine kinase, Transactivation, Transcription (biology), Transmission electron microscopy, Transporter associated with antigen processing, Trigeminal ganglion, Ubiquitin, Uracil-DNA glycosylase, Valaciclovir, Vertex (geometry), Vertically transmitted infection, Vesicle (biology and chemistry), Viral entry, Viral envelope, Viral shedding, Viral tegument, Virus, Virus latency. Expand index (64 more) » « Shrink index
Aciclovir (ACV), also known as acyclovir, is an antiviral medication.
In chemistry, an alkali (from Arabic: al-qaly “ashes of the saltwort”) is a basic, ionic salt of an alkali metal or alkaline earth metal chemical element.
An allele is a variant form of a given gene.
Alphaherpesvirinae is a subfamily of Herpesviridae, primarily distinguished by reproducing more quickly than other subfamilies of Herpesviridae.
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California.
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
Antigen presentation describes a vital immune process which is essential for T cell immune response triggering.
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones.
Apolipoprotein E (ApoE) is a class of proteins involved in the metabolism of fats in the body.
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning "self-devouring" and κύτος kýtos, meaning "hollow") is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components.
An axon (from Greek ἄξων áxōn, axis) or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that typically conducts electrical impulses known as action potentials, away from the nerve cell body.
A blister is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, typically caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection.
A capsid is the protein shell of a virus.
The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the membranes of cells.
A clade (from κλάδος, klados, "branch"), also known as monophyletic group, is a group of organisms that consists of a common ancestor and all its lineal descendants, and represents a single "branch" on the "tree of life".
Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.
A concatemer is a long continuous DNA molecule that contains multiple copies of the same DNA sequence linked in series.
A crossover study, also referred to as a crossover trial, is a longitudinal study in which subjects receive a sequence of different treatments (or exposures).
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
DNA polymerases are enzymes that synthesize DNA molecules from deoxyribonucleotides, the building blocks of DNA.
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.
A DNA virus is a virus that has DNA as its genetic material and replicates using a DNA-dependent DNA polymerase.
In enzymology, a dUTP diphosphatase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are dUTP and H2O, whereas its two products are dUMP and diphosphate.
The classification of viral proteins as early proteins or late proteins depends on their relationship with genome replication.
Endocytosis is a form of bulk transport in which a cell transports molecules (such as proteins) into the cell (endo- + cytosis) by engulfing them in an energy-using process.
In cell biology, an endosome is a membrane-bound compartment inside eukaryotic cells.
Enzymes are macromolecular biological catalysts.
Exonucleases are enzymes that work by cleaving nucleotides one at a time from the end (exo) of a polynucleotide chain.
In biotechnology, flow cytometry is a laser- or impedance-based, biophysical technology employed in cell counting, cell sorting, biomarker detection and protein engineering, by suspending cells in a stream of fluid and passing them through an electronic detection apparatus.
A ganglion is a nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system and sensory system.
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
In the fields of molecular biology and genetics, a genome is the genetic material of an organism.
Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to amino acid side-chains.
Glycosaminoglycans (GAGs) or mucopolysaccharides are long unbranched polysaccharides consisting of a repeating disaccharide unit.
A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase.
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues.
Herpes labialis, also known as cold sores, is a type of infection by the herpes simplex virus that affects primarily the lip.
Herpes simplex is a viral disease caused by the herpes simplex virus.
Herpes simplex research includes all medical research that attempts to prevent, treat, or cure herpes, as well as fundamental research about the nature of herpes.
Herpesviral encephalitis is encephalitis due to herpes simplex virus.
The Herpesvirales is an order of dsDNA viruses with eukaryotic hosts and enveloped virions, characterized by a common morphology.
Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans.
Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily.
Herpesvirus glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus (HSV).
A herpetic whitlow is a lesion (whitlow) on a finger or thumb caused by the herpes simplex virus.
HHV Capsid Portal Protein, or HSV-1 UL-6 protein, is the protein which forms a cylindrical portal in the capsid of Herpes simplex virus (HSV-1).
Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses.
HHV Latency Associated Transcript (HHV LAT) is a length of RNA which accumulates in cells hosting long-term, or latent, Human Herpes Virus (HHV) infections.
Histology, also microanatomy, is the study of the anatomy of cells and tissues of plants and animals using microscopy.
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes.
Humans (taxonomically Homo sapiens) are the only extant members of the subtribe Hominina.
In geometry, an icosahedron is a polyhedron with 20 faces.
Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli.
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
Infected cell protein 47 also ICP-47 or ICP47 is a protein secreted by the viruses such as Herpes simplex virus and Cytomegalovirus that allows them to evade the human immune system's CD8 T-cell response.
Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.
Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is HHV-8.
A kiss is the touch or pressing of one's lips against another person or an object.
A leucine zipper (or leucine scissors) is a common three-dimensional structural motif in proteins.
The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules.
A lipoprotein is a biochemical assembly whose purpose is to transport hydrophobic lipid (a.k.a. fat) molecules in water, as in blood or extracellular fluid.
The lytic cycle is one of the two cycles of viral reproduction (referring to bacterial viruses or bacteriophages), the other being the lysogenic cycle.
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
Methyl methanesulfonate (MMS), also known as methyl mesylate, is an alkylating agent and a carcinogen.
MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates.
A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnified image of an item.
Mollaret's meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.
In biology and genealogy, the most recent common ancestor (MRCA, also last common ancestor (LCA), or concestor) of any set of organisms is the most recent individual from which all the organisms are directly descended.
A mucous membrane or mucosa is a membrane that lines various cavities in the body and covers the surface of internal organs.
Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules involved in Ca2+-independent cellular adhesion.
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
A neurotropic virus is a virus that is capable of infecting nerve cells.
An oncolytic virus is a virus that preferentially infects and kills cancer cells.
In molecular genetics, an open reading frame (ORF) is the part of a reading frame that has the ability to be translated.
Oral sex, sometimes referred to as oral intercourse, is sexual activity involving the stimulation of the genitalia of a person by another person using the mouth (including the lips, tongue or teeth) or throat.
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.
In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).
Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene.
RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST gene, and acts as a transcriptional repressor.
In geometry, a regular icosahedron is a convex polyhedron with 20 faces, 30 edges and 12 vertices.
Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase (rNDP), is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides.
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.
RNA polymerase II (RNAP II and Pol II) is a multiprotein complex.
The sacral ganglia are paravertebral ganglia of the sympathetic trunk.
Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.
Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae.
Skin is the soft outer tissue covering vertebrates.
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the TMEM173 gene.
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.
Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 126.96.36.199.
In the context of gene regulation: transactivation is the increased rate of gene expression triggered either by biological processes or by artificial means, through the expression of an intermediate transactivator protein.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
Transmission electron microscopy (TEM, also sometimes conventional transmission electron microscopy or CTEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image.
Transporter associated with antigen processing (TAP) is a member of the ATP-binding-cassette transporter family.
The trigeminal ganglion (or Gasserian ganglion, or semilunar ganglion, or Gasser's ganglion) is a sensory ganglion of the trigeminal nerve (CN V) that occupies a cavity (Meckel's cave) in the dura mater, covering the trigeminal impression near the apex of the petrous part of the temporal bone.
Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.
Uracil-DNA glycosylase, also known as UNG or UDG, is an enzyme.
Valaciclovir, also spelled valacyclovir, is an antiviral drug used in the management of herpes simplex, herpes zoster (shingles), and herpes B. It is a prodrug, being converted in vivo to aciclovir.
In geometry, a vertex (plural: vertices or vertexes) is a point where two or more curves, lines, or edges meet.
A vertically transmitted infection is an infection caused by pathogens (such as bacteria and viruses) that uses mother-to-child transmission, that is, transmission directly from the mother to an embryo, fetus, or baby during pregnancy or childbirth.
In cell biology, a vesicle is a small structure within a cell, or extracellular, consisting of fluid enclosed by a lipid bilayer.
Viral entry is the earliest stage of infection in the viral life cycle, as the virus comes into contact with the host cell and introduces viral material into the cell.
Some viruses (e.g. HIV and many animal viruses) have viral envelopes covering their protective protein capsids.
Viral shedding refers to the expulsion and release of virus progeny following successful reproduction during a host-cell infection.
A viral tegument or tegument, more commonly known as a viral matrix, is a cluster of proteins that lines the space between the envelope and nucleocapsid of all herpesviruses.
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
Virus latency (or viral latency) is the ability of a pathogenic virus to lie dormant (latent) within a cell, denoted as the lysogenic part of the viral life cycle.
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