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Ibalizumab

Index Ibalizumab

Ibalizumab (trade name Trogarzo) is a non-immunosuppressive monoclonal antibody that binds CD4, the primary receptor for HIV, and inhibits the viral entry process. [1]

17 relations: Aaron Diamond AIDS Research Center, CD4, Clinical trial, CXCR4, David Ho, Entry inhibitor, Genentech, HIV, HIV tropism, Injection (medicine), Intravenous therapy, Monoclonal antibody, Placebo, Statistical significance, T helper cell, Tanox, Viral load.

Aaron Diamond AIDS Research Center

Aaron Diamond AIDS Research Center, often abbreviated as ADARC, is a medical research institution dedicated to finding a cure for HIV/AIDS.

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CD4

In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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CXCR4

C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene.

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David Ho

David Da-i Ho (born November 3, 1952) is a Taiwanese-American medical doctor and HIV/AIDS researcher who was born in Taiwan and has made many innovative state of the art scientific contributions to the understanding and technological treatment of HIV infection.

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Entry inhibitor

Entry inhibitors, also known as fusion inhibitors, are a class of antiretroviral drugs, used in combination therapy for the treatment of HIV infection.

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Genentech

Genentech, Inc., is a biotechnology corporation which became a subsidiary of Roche in 2009.

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HIV

The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).

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HIV tropism

HIV tropism refers to the cell type that the human immunodeficiency virus (HIV) infects and replicates in.

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Injection (medicine)

Injection (often referred to as a "shot" in US English, or a "jab" in UK English) is the act of putting a liquid, especially a drug, into a person's body using a needle (usually a hypodermic needle) and a syringe.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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Placebo

A placebo is a substance or treatment of no intended therapeutic value.

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Statistical significance

In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.

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T helper cell

The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.

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Tanox

Tanox was a biopharmaceutical company based in Houston, Texas.

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Viral load

Viral load, also known as viral burden, viral titre or viral titer, is a numerical expression of the quantity of virus in a given volume.

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Redirects here:

Ibalizumab-uiyk, TNX-355, Trogarzo.

References

[1] https://en.wikipedia.org/wiki/Ibalizumab

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