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83 relations: Acute lymphoblastic leukemia, Albert Coons, Alkaline phosphatase, Alpha-fetoprotein, Antibody, Antigen, Antiserum, Apoptosis, Avidin, B cell, Biomarker, Biotin, Bovine serum albumin, Bromodeoxyuridine, Cancer, CD117, CD20, CD3 (immunology), Cetuximab, Chromogenic in situ hybridization, Chronic myelogenous leukemia, Cluster of differentiation, Cross-reactivity, Cryostat, Cytokeratin, DAPI, Endodermal sinus tumor, Enzyme, Epidermal growth factor receptor, Epitope, Estrogen, Fixation (histology), Fluorescein, Fluorescein isothiocyanate, Fluorescence, Fluorophore, Gastrointestinal stromal tumor, Haematoxylin, Hepatocellular carcinoma, HER2/neu, Hodgkin's lymphoma, Hoechst stain, Horseradish peroxidase, Imatinib, Immortalised cell line, Immunocytochemistry, Immunofluorescence, Immunoglobulin G, Immunoperoxidase, List of immunofluorescence findings for autoimmune bullous conditions, ..., Lymphoma, Microtome, Molecular mass, Monoclonal antibody, Neprilysin, Neuroscience, NeutrAvidin, Nickel, Nitro blue tetrazolium chloride, Paraformaldehyde, Peroxidase, Polyclonal antibodies, Primary and secondary antibodies, Progesterone, Prostate cancer, Prostate-specific antigen, Protease, Renal cell carcinoma, Rhodamine, Staining, Streptavidin, Surgical pathology, T cell, Tamoxifen, Tissue (biology), Tyrosine kinase, University of Rochester, Ventana Medical Systems, Vibratome, Western blot, Xylene, 3,3'-Diaminobenzidine, 5-Bromo-4-chloro-3-indolyl phosphate. Expand index (33 more) »
Acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes.
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Albert Coons
Albert Hewett Coons (June 28, 1912 – September 30, 1978) was an American physician, pathologist, and immunologist.
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Alkaline phosphatase
Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) or basic phosphatase is a homodimeric protein enzyme of 86 kilodaltons.
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Alpha-fetoprotein
Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the AFP gene.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Antigen
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.
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Antiserum
Antiserum (plural: antisera) is human or nonhuman blood serum containing polyclonal antibodies and is used to pass on passive immunity to many diseases.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Avidin
Avidin is a tetrameric biotin-binding protein produced in the oviducts of birds, reptiles and amphibians and deposited in the whites of their eggs.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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Biomarker
A biomarker, or biological marker, generally refers to a measurable indicator of some biological state or condition.
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Biotin
Biotin is a water-soluble B vitamin, also called vitamin B7 and formerly known as vitamin H or coenzyme R. Biotin is composed of a ureido ring fused with a tetrahydrothiophene ring.
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Bovine serum albumin
Bovine serum albumin (also known as BSA or "Fraction V") is a serum albumin protein derived from cows.
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Bromodeoxyuridine
Bromodeoxyuridine (5-bromo-2'-deoxyuridine, BrdU, BUdR, BrdUrd, broxuridine) is a synthetic nucleoside that is an analog of thymidine.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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CD117
Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in humans is encoded by the KIT gene.
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CD20
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity.
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CD3 (immunology)
In immunology, the CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8+ naive T cells) and also T helper cells (CD4+ naive T cells).
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Cetuximab
Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer and head and neck cancer.
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Chromogenic in situ hybridization
Chromogenic in situ hybridization (CISH) is a cytogenetic technique that combines the chromogenic signal detection method of immunohistochemistry (IHC) techniques with in situ hybridization.
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Chronic myelogenous leukemia
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.
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Cross-reactivity
Cross-reactivity, in a general sense, applies to the reaction between two different species as opposed to self-reactivity.
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Cryostat
A cryostat (from cryo meaning cold and stat meaning stable) is a device used to maintain low cryogenic temperatures of samples or devices mounted within the cryostat.
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Cytokeratin
Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue.
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DAPI
DAPI, or 4′,6-diamidino-2-phenylindole, is a fluorescent stain that binds strongly to adenine–thymine rich regions in DNA.
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Endodermal sinus tumor
Endodermal sinus tumor (EST), also known as yolk sac tumor (YST), is a member of the germ cell tumor group of cancers.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Epitope
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.
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Estrogen
Estrogen, or oestrogen, is the primary female sex hormone.
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Fixation (histology)
In the fields of histology, pathology, and cell biology, fixation is the preservation of biological tissues from decay due to autolysis or putrefaction.
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Fluorescein
Fluorescein is a manufactured organic compound and dye.
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Fluorescein isothiocyanate
Fluorescein isothiocyanate (FITC) is a derivative of fluorescein used in wide-ranging applications including flow cytometry.
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Fluorescence
Fluorescence is the emission of light by a substance that has absorbed light or other electromagnetic radiation.
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Fluorophore
A fluorophore (or fluorochrome, similarly to a chromophore) is a fluorescent chemical compound that can re-emit light upon light excitation.
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Gastrointestinal stromal tumor
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract.
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Haematoxylin
Haematoxylin or hematoxylin, also called natural black 1 or C.I. 75290, is a compound extracted from the heartwood of the logwood tree (Haematoxylum campechianum).
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Hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis.
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HER2/neu
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent), or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene.
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Hodgkin's lymphoma
Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.
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Hoechst stain
Hoechst stains are part of a family of blue fluorescent dyes used to stain DNA.
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Horseradish peroxidase
The enzyme horseradish peroxidase (HRP), found in the roots of horseradish, is used extensively in biochemistry applications.
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Imatinib
Imatinib, sold under the brand names Gleevec among others, is a medication used to treat cancer.
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Immortalised cell line
An immortalized cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division.
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Immunocytochemistry
Immunocytochemistry (ICC) is a common laboratory technique that is used to anatomically visualize the localization of a specific protein or antigen in cells by use of a specific primary antibody that binds to it.
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Immunofluorescence
Immunofluorescence is a technique used for light microscopy with a fluorescence microscope and is used primarily on microbiological samples.
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Immunoglobulin G
Immunoglobulin G (IgG) is a type of antibody.
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Immunoperoxidase
Immunoperoxidase is a type of immunostain used in molecular biology, medical research, and clinical diagnostics.
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List of immunofluorescence findings for autoimmune bullous conditions
Several cutaneous conditions can be diagnosed with the aid of immunofluorescence studies.
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Lymphoma
Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).
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Microtome
A microtome (from the Greek mikros, meaning "small", and temnein, meaning "to cut") is a tool used to cut extremely thin slices of material, known as sections.
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Molecular mass
Relative Molecular mass or molecular weight is the mass of a molecule.
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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Neprilysin
Neprilysin, also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene.
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Neuroscience
Neuroscience (or neurobiology) is the scientific study of the nervous system.
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NeutrAvidin
NeutrAvidin protein is a deglycosylated version of avidin, with a mass of approximately 60,000 daltons.
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Nickel
Nickel is a chemical element with symbol Ni and atomic number 28.
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Nitro blue tetrazolium chloride
Nitro blue tetrazolium is a chemical compound composed of two tetrazole moieties.
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Paraformaldehyde
Paraformaldehyde (PFA) is the smallest polyoxymethylene, the polymerization product of formaldehyde with a typical degree of polymerization of 8–100 units.
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Peroxidase
Peroxidases (EC number) are a large family of enzymes that typically catalyze a reaction of the form: For many of these enzymes the optimal substrate is hydrogen peroxide, but others are more active with organic hydroperoxides such as lipid peroxides.
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Polyclonal antibodies
Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage).
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Primary and secondary antibodies
Primary and secondary antibodies are two groups of antibodies that are classified based on whether they bind to antigens or proteins directly or target another (primary) antibody that, in turn, is bound to an antigen or protein.
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Progesterone
Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
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Prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.
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Prostate-specific antigen
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus. PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia.
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Protease
A protease (also called a peptidase or proteinase) is an enzyme that performs proteolysis: protein catabolism by hydrolysis of peptide bonds.
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Renal cell carcinoma
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.
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Rhodamine
Rhodamine is a family of related chemical compounds, fluorone dyes.
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Staining
Staining is an auxiliary technique used in microscopy to enhance contrast in the microscopic image.
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Streptavidin
Streptavidin is a 52.8 kDa protein purified from the bacterium Streptomyces avidinii.
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Surgical pathology
Surgical pathology is the most significant and time-consuming area of practice for most anatomical pathologists.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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Tamoxifen
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.
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Tissue (biology)
In biology, tissue is a cellular organizational level between cells and a complete organ.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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University of Rochester
The University of Rochester (U of R or UR) frequently referred to as Rochester, is a private research university in Rochester, New York.
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Ventana Medical Systems
Ventana Medical Systems, Inc. is a global leader in tissue diagnostics.
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Vibratome
A vibratome is an instrument that is similar to a microtome but uses a vibrating razor blade to cut through tissue.
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Western blot
The western blot (sometimes called the protein immunoblot) is a widely used analytical technique used in molecular biology, immunogenetics and other molecular biology disciplines to detect specific proteins in a sample of tissue homogenate or extract.
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Xylene
Xylene (from Greek ξύλο, xylo, "wood"), xylol or dimethylbenzene is any one of three isomers of dimethylbenzene, or a combination thereof.
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3,3'-Diaminobenzidine
3,3'-Diaminobenzidine (DAB) is an organic compound with the formula (C6H3(NH2)2)2.
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5-Bromo-4-chloro-3-indolyl phosphate
5-Bromo-4-chloro-3-indolyl phosphate (BCIP, X-phosphate, XP) is an artificial chromogenic substrate used for the sensitive colorimetric detection of alkaline phosphatase activity.
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Histochemistry, IHC marker, Immune-histochemistry, Immunecytochemistry, Immunhistochemistry, Immunohistochemical, Immunohistochemical staining, Immunohistochemical studies, Immunohistochemist.
References
[1] https://en.wikipedia.org/wiki/Immunohistochemistry
