29 relations: CD4, Cell growth, Common gamma chain, CXCR3, Cytokine, Cytotoxic T cell, Follicular B helper T cells, Gene, Granzyme B, Hodgkin's lymphoma, IL-2 receptor, Immune system, Interferon gamma, Interleukin-21 receptor, Long-term nonprogressor, Lymphocytic choriomeningitis, Melanoma, Natural killer cell, Natural killer T cell, Neutrophil, Perforin, Platelet, Protein, Renal cell carcinoma, Response evaluation criteria in solid tumors, Rituximab, T cell, T helper 17 cell, T helper cell.
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
The term cell growth is used in the contexts of biological cell development and cell division (reproduction).
The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor.
Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family.
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
Follicular B helper T cells (also known as just follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5.
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs), natural killer cells (NK cells) and cytotoxic T cells.
Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.
The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
Interleukin 21 receptor is a type I cytokine receptor.
Long-term nonprogressors (LTNPs), sometimes also called "elite controllers", are individuals infected with HIV, who maintain a CD4 count greater than 500 without antiretroviral therapy with a detectable viral load.
Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis.
Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.
Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.
Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells.
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.
Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve ("respond"), stay the same ("stabilize"), or worsen ("progress") during treatment.
Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer.
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).
The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.