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Interleukin 21

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Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. [1]

29 relations: CD4, Cell growth, Common gamma chain, CXCR3, Cytokine, Cytotoxic T cell, Follicular B helper T cells, Gene, Granzyme B, Hodgkin's lymphoma, IL-2 receptor, Immune system, Interferon gamma, Interleukin-21 receptor, Long-term nonprogressor, Lymphocytic choriomeningitis, Melanoma, Natural killer cell, Natural killer T cell, Neutrophil, Perforin, Platelet, Protein, Renal cell carcinoma, Response evaluation criteria in solid tumors, Rituximab, T cell, T helper 17 cell, T helper cell.


In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.

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Cell growth

The term cell growth is used in the contexts of biological cell development and cell division (reproduction).

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Common gamma chain

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor.

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Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family.

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Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Cytotoxic T cell

A cytotoxic T cell (also known as TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.

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Follicular B helper T cells

Follicular B helper T cells (also known as just follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5.

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Granzyme B

Granzyme B is a serine protease most commonly found in the granules of cytotoxic lymphocytes (CTLs), natural killer cells (NK cells) and cytotoxic T cells.

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Hodgkin's lymphoma

Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.

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IL-2 receptor

The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Interferon gamma

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.

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Interleukin-21 receptor

Interleukin 21 receptor is a type I cytokine receptor.

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Long-term nonprogressor

Long-term nonprogressors (LTNPs), sometimes also called "elite controllers", are individuals infected with HIV, who maintain a CD4 count greater than 500 without antiretroviral therapy with a detectable viral load.

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Lymphocytic choriomeningitis

Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis.

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Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Natural killer cell

Natural killer cells or NK cells are a type of cytotoxic lymphocyte critical to the innate immune system.

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Natural killer T cell

Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells.

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Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.

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Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice.

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Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Renal cell carcinoma

Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine.

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Response evaluation criteria in solid tumors

Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve ("respond"), stay the same ("stabilize"), or worsen ("progress") during treatment.

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Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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T helper 17 cell

T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).

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T helper cell

The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.

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Redirects here:

IL21 (gene), Interleukin-21.


[1] https://en.wikipedia.org/wiki/Interleukin_21

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