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Inverse agonist

Index Inverse agonist

In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist. [1]

20 relations: Agonist, Agouti signalling peptide, Agouti-related peptide, Anxiogenic, Benzodiazepine, Beta-Carboline, Convulsion, GABAA receptor, Intrinsic activity, Ligand (biochemistry), Melanocortin 1 receptor, Melanocortin 4 receptor, Naloxone, Naltrexone, Opioid antagonist, Pharmacology, Receptor (biochemistry), Receptor antagonist, Ro15-4513, Sedative.


An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Agouti signalling peptide

Agouti signalling peptide, a product of the Agouti gene, is a peptide consisting of 131 amino acids.

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Agouti-related peptide

Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron.

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An anxiogenic or panicogenic substance is one that causes anxiety.

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Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

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β-Carboline (9H-pyridoindole), also known as norharmane, is a nitrogen containing heterocycle.

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A convulsion is a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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Intrinsic activity

Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Melanocortin 1 receptor

The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH).

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Melanocortin 4 receptor

Melanocortin 4 receptor is a protein that in humans is encoded by the MC4R gene.

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Naloxone, sold under the brandname Narcan among others, is a medication used to block the effects of opioids, especially in overdose.

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Naltrexone, sold under the brand names ReVia and Vivitrol among others, is a medication primarily used to manage alcohol or opioid dependence.

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Opioid antagonist

An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors.

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Pharmacology is the branch of biology concerned with the study of drug action, where a drug can be broadly defined as any man-made, natural, or endogenous (from within body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharmacon is used as a term to encompass these endogenous and exogenous bioactive species).

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Receptor (biochemistry)

In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Ro15-4513 is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann–La Roche in the 1980s.

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A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.

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Inverse agonists, Inverse antagonist, Receptor inverse agonist.


[1] https://en.wikipedia.org/wiki/Inverse_agonist

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