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47 relations: Antennapedia, Apoptosis, B cell, BCL10, C-terminus, Cancer, CDC37, CHUK, Diabetes mellitus, Diffuse large B-cell lymphoma, Downregulation and upregulation, Gene, Germinal center, Great Ormond Street Hospital, HeLa, Homeobox, Hypohidrotic ectodermal dysplasia, IκB kinase, IκBα, IKK2, Incontinentia pigmenti, Intraperitoneal injection, Intravenous therapy, IRAK1, Mutant, NEMO deficiency syndrome, NF-κB, Nuclear receptor coactivator 3, Osteoclast, Pathology, Peptide, Phosphorylation, PPM1B, Proteasome, Protein, Protein–protein interaction, RELA, Rheumatoid arthritis, Signal transduction, Small molecule, Systemic inflammation, TANK (gene), TNFAIP3, TRAF3IP2, TRAF6, Tumor necrosis factor alpha, Wild type.
Antennapedia
Antennapedia is a HOM-C gene first discovered in Drosophila which controls the formation of legs during development.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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BCL10
B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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CDC37
Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene.
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CHUK
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene.
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Diabetes mellitus
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
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Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL or DLBL) is a cancer of B cells, a type of white blood cell responsible for producing antibodies.
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Downregulation and upregulation
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Germinal center
Germinal centers or germinal centres (GCs) are sites within secondary lymphoid organs – lymph nodes and the spleen where mature B cells proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity), and switch the class of their antibodies (for example from IgM to IgG) during a normal immune response to an infection.
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Great Ormond Street Hospital
Great Ormond Street Hospital (informally GOSH or Great Ormond Street, formerly the Hospital for Sick Children) is a children's hospital located in the Bloomsbury area of the London Borough of Camden, and a part of Great Ormond Street Hospital for Children NHS Foundation Trust.
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HeLa
HeLa (also Hela or hela) is a cell type in an immortal cell line used in scientific research.
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Homeobox
A homeobox is a DNA sequence, around 180 base pairs long, found within genes that are involved in the regulation of patterns of anatomical development (morphogenesis) in animals, fungi and plants.
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Hypohidrotic ectodermal dysplasia
Hypohidrotic ectodermal dysplasia (also known as "anhidrotic ectodermal dysplasia", and "Christ-Siemens-Touraine syndrome"James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders..) is one of about 150 types of ectodermal dysplasia in humans.
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IκB kinase
The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.
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IκBα
IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.
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IKK2
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.
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Incontinentia pigmenti
Incontinentia pigmenti (IP) is a rare genetic disorder that affects the skin, hair, teeth, nails, and central nervous system.
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Intraperitoneal injection
Intraperitoneal injection or IP injection is the injection of a substance into the peritoneum (body cavity).
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Intravenous therapy
Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).
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IRAK1
Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.
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Mutant
In biology and especially genetics, a mutant is an organism or a new genetic character arising or resulting from an instance of mutation, which is an alteration of the DNA sequence of a gene or chromosome of an organism.
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NEMO deficiency syndrome
Nuclear factor-kappa B Essential Modulator (NEMO) deficiency syndrome is a rare type of primary immunodeficiency disease that has a highly variable set of symptoms and prognoses.
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NF-κB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
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Nuclear receptor coactivator 3
The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.
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Osteoclast
An osteoclast is a type of bone cell that breaks down bone tissue.
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Pathology
Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Phosphorylation
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
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PPM1B
Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.
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Proteasome
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RELA
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.
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Rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Small molecule
Within the fields of molecular biology and pharmacology, a small molecule is a low molecular weight (< 900 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.
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Systemic inflammation
Chronic systemic inflammation (SI) is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.
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TANK (gene)
TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.
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TNFAIP3
Tumor necrosis factor, alpha-induced protein 3 is a protein that in humans is encoded by the TNFAIP3 gene.
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TRAF3IP2
Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.
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TRAF6
TRAF6 is a TRAF human protein.
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Tumor necrosis factor alpha
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
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Wild type
Wild type (WT) refers to the phenotype of the typical form of a species as it occurs in nature.
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Redirects here:
FIP-3, FIP3, Fip-3, Fip3, Fip3p, IKBKG (gene), IKK-gamma, IP1, IP2, Ikk-gamma, Inhibitor of kappa light polypeptide gene enhancer in B-cells, Ip1, Ip2, NEMO gene, NEMO protein.
References
[1] https://en.wikipedia.org/wiki/IKBKG
