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Isoprostane

Index Isoprostane

The isoprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily arachidonic acid) without the direct action of cyclooxygenase (COX) enzymes. [1]

14 relations: Arachidonic acid, COX-2 inhibitor, Cyclooxygenase, Docosahexaenoic acid, Eicosapentaenoic acid, Essential fatty acid, Free Radical Biology and Medicine, Inflammation, Lipid peroxidation, Neuroprostanes, Nonclassic eicosanoid, Oxidative stress, Pain, Prostaglandin.

Arachidonic acid

Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).

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COX-2 inhibitor

Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain.

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Cyclooxygenase

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid.

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Docosahexaenoic acid

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina.

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Eicosapentaenoic acid

Eicosapentaenoic acid (EPA; also icosapentaenoic acid) is an omega-3 fatty acid.

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Essential fatty acid

Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health but cannot synthesize them.

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Free Radical Biology and Medicine

Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Free Radical Biology and Medicine.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Lipid peroxidation

Lipid peroxidation is the oxidative degradation of lipids.

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Neuroprostanes

The neuroprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily docosahexaenoic acid) without the direct action of cyclooxygenase (COX) enzymes.

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Nonclassic eicosanoid

Nonclassic eicosanoids are biologically active signaling molecules made by oxygenation of twenty-carbon fatty acids other than the classic eicosanoids.

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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Pain

Pain is a distressing feeling often caused by intense or damaging stimuli.

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Prostaglandin

The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.

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Redirects here:

D4-isoprostane, D4-isoprostanes, E1-isoprostane, E1-isoprostanes, E4-isoprostane, E4-isoprostanes, F1-isoprostane, F1-isoprostanes, F2-isoprostane, F2-isoprostanes, F3 isoprostane, F3 isoprostanes, Isoprostanes.

References

[1] https://en.wikipedia.org/wiki/Isoprostane

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