14 relations: Arachidonic acid, COX-2 inhibitor, Cyclooxygenase, Docosahexaenoic acid, Eicosapentaenoic acid, Essential fatty acid, Free Radical Biology and Medicine, Inflammation, Lipid peroxidation, Neuroprostanes, Nonclassic eicosanoid, Oxidative stress, Pain, Prostaglandin.
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).
Selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug (NSAID) that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain.
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina.
Eicosapentaenoic acid (EPA; also icosapentaenoic acid) is an omega-3 fatty acid.
Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health but cannot synthesize them.
Free Radical Biology and Medicine is a peer-reviewed scientific journal and official journal of the Society for Free Radical Biology and Medicine.
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
Lipid peroxidation is the oxidative degradation of lipids.
The neuroprostanes are prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of essential fatty acids (primarily docosahexaenoic acid) without the direct action of cyclooxygenase (COX) enzymes.
Nonclassic eicosanoids are biologically active signaling molecules made by oxygenation of twenty-carbon fatty acids other than the classic eicosanoids.
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.
Pain is a distressing feeling often caused by intense or damaging stimuli.
The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.
D4-isoprostane, D4-isoprostanes, E1-isoprostane, E1-isoprostanes, E4-isoprostane, E4-isoprostanes, F1-isoprostane, F1-isoprostanes, F2-isoprostane, F2-isoprostanes, F3 isoprostane, F3 isoprostanes, Isoprostanes.