Cocaine, also known as benzoylmethylecgonine or coke, is a strong stimulant mostly used as a recreational drug.
New!!: J-113,397 and Cocaine ·
Dopamine is an organic chemical of the catecholamine and phenethylamine families that plays a number of important roles in the human brain and body, as well as elsewhere in biology.
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A drug is, in the broadest of terms, a chemical substance that has known biological effects on humans or other animals.
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Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves.
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JTC-801 is an opioid analgesic drug used in scientific research.
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LY-2940094 is a potent and selective nociceptin receptor antagonist which is under investigation by Eli Lilly for the treatment of major depressive disorder and alcohol dependence.
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Morphine, sold under many trade names, is a pain medication of the opiate type.
New!!: J-113,397 and Morphine ·
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1).
New!!: J-113,397 and Nociceptin ·
The nociceptin receptor or NOP also known as the orphanin FQ receptor or kappa-type 3 opioid receptor is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene.
New!!: J-113,397 and Nociceptin receptor ·
An "opioid" is any synthetic narcotic not derived from opium.
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Parkinson's disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome (HRS), or paralysis agitans) is a degenerative disorder of the central nervous system mainly affecting the motor system.
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SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397.
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The striatum, also known as the neostriatum or striate nucleus, is a subcortical part of the forebrain and a critical component of the reward system.
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Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute (sudden) decrease in the response to a drug after its administration.
New!!: J-113,397 and Tachyphylaxis ·