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KDEL (amino acid sequence)

Index KDEL (amino acid sequence)

KDEL is a target peptide sequence in the amino acid structure of a protein which prevents the protein from being secreted from the endoplasmic reticulum (ER) and facilitates its return if it is accidentally exported. [1]

15 relations: Amino acid, Aspartic acid, Cytoplasm, Endoplasmic reticulum, ER retention, Glutamic acid, Golgi apparatus, KDELR1, KDELR2, KDELR3, KKXX (amino acid sequence), Leucine, Lysine, Protein, Target peptide.

Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Aspartic acid

Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Endoplasmic reticulum

The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.

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ER retention

ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Golgi apparatus

The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells.

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KDELR1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, also known as KDELR1, is a protein which in humans is encoded by the KDELR1 gene.

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KDELR2

ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.

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KDELR3

ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene.

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KKXX (amino acid sequence)

KKXX and for some proteins XKXX is a target peptide motif located in the C terminus in the amino acid structure of a protein responsible for retrieval of endoplasmic reticulum (ER) membrane proteins from the Golgi apparatus.

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Leucine

Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.

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Lysine

Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Target peptide

A target peptide is a short (3-70 amino acids long) peptide chain that directs the transport of a protein to a specific region in the cell, including the nucleus, mitochondria, endoplasmic reticulum (ER), chloroplast, apoplast, peroxisome and plasma membrane.

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Redirects here:

KDEL (amino acid), KDEL sequence.

References

[1] https://en.wikipedia.org/wiki/KDEL_(amino_acid_sequence)

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