Table of Contents
77 relations: Acute myeloid leukemia, Adapter molecule crk, Agonist, Antibody, Antibody–drug conjugate, BCR (gene), Bone marrow, Cancer, CD63, CD81, CD9, Cell membrane, CFU-GEMM, Cluster of differentiation, CRKL, CXCR4, Cytokine receptor, Cytoplasm, Dasatinib, Desmin, DOK1, Embryonal carcinoma, Gametogenesis, Gastrointestinal stromal tumor, Gastrointestinal tract, Germ cell tumor, Granulocyte colony-stimulating factor, GRB10, GRB2, Haematopoiesis, Hematopoietic stem cell, Hematopoietic stem cell transplantation, Histology, Imatinib, Immunohistochemistry, Interstitial cell of Cajal, Leiomyosarcoma, Leukemia, List of genes mutated in cutaneous conditions, Lymphopoiesis, LYN, Lysosome, Mast cell, Mastocytoma, Megakaryocyte-associated tyrosine kinase, Melanie Welham, Melanocyte, Melanoma, MPDZ, Nilotinib, ... Expand index (27 more) »
- EC 2.7.10
- Immunoglobulin superfamily cytokine receptors
Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production.
See KIT (gene) and Acute myeloid leukemia
Adapter molecule crk
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.
See KIT (gene) and Adapter molecule crk
Agonist
An agonist is a chemical that activates a receptor to produce a biological response.
Antibody
An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form of the B cell receptor, but they are, broadly speaking, the same protein, and so the terms are often treated as synonymous.
Antibody–drug conjugate
Antibody–drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer.
See KIT (gene) and Antibody–drug conjugate
BCR (gene)
The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene.
Bone marrow
Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones.
See KIT (gene) and Bone marrow
Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
CD63
CD63 antigen is a protein that, in humans, is encoded by the CD63 gene.
CD81
CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene.
CD9
CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family.
Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
See KIT (gene) and Cell membrane
CFU-GEMM
CFU-GEMM is a colony forming unit that generates myeloid cells.
Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.
See KIT (gene) and Cluster of differentiation
CRKL
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
CXCR4
C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene.
Cytokine receptor
Cytokine receptors are receptors that bind to cytokines.
See KIT (gene) and Cytokine receptor
Cytoplasm
In cell biology, the cytoplasm describes all material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus.
Dasatinib
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL).
Desmin
Desmin is a protein that in humans is encoded by the DES gene.
DOK1
Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.
Embryonal carcinoma
Embryonal carcinoma is a relatively uncommon type of nonseminomatous germ cell tumour that occurs in the ovaries and testes.
See KIT (gene) and Embryonal carcinoma
Gametogenesis
Gametogenesis is a biological process by which diploid or haploid precursor cells undergo cell division and differentiation to form mature haploid gametes.
See KIT (gene) and Gametogenesis
Gastrointestinal stromal tumor
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract.
See KIT (gene) and Gastrointestinal stromal tumor
Gastrointestinal tract
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and other animals, including the esophagus, stomach, and intestines.
See KIT (gene) and Gastrointestinal tract
Germ cell tumor
Germ cell tumor (GCT) is a neoplasm derived from the primordial germ cells.
See KIT (gene) and Germ cell tumor
Granulocyte colony-stimulating factor
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
See KIT (gene) and Granulocyte colony-stimulating factor
GRB10
Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.
GRB2
Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication.
Haematopoiesis
Haematopoiesis (from Greek αἷμα, 'blood' and ποιεῖν 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation of blood cellular components.
See KIT (gene) and Haematopoiesis
Hematopoietic stem cell
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.
See KIT (gene) and Hematopoietic stem cell
Hematopoietic stem cell transplantation
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells.
See KIT (gene) and Hematopoietic stem cell transplantation
Histology
Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissues.
Imatinib
Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer.
Immunohistochemistry
Immunohistochemistry is a form of immunostaining.
See KIT (gene) and Immunohistochemistry
Interstitial cell of Cajal
Interstitial cells of Cajal (ICC) are interstitial cells found in the gastrointestinal tract.
See KIT (gene) and Interstitial cell of Cajal
Leiomyosarcoma
A leiomyosarcoma, also known as LMS, is a rare malignant (cancerous) smooth muscle tumor.
See KIT (gene) and Leiomyosarcoma
Leukemia
Leukemia (also spelled leukaemia; pronounced) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells.
List of genes mutated in cutaneous conditions
A number of gene mutations have been linked to conditions of or affecting the human integumentary system.
See KIT (gene) and List of genes mutated in cutaneous conditions
Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cells (WBCs).
See KIT (gene) and Lymphopoiesis
LYN
Tyrosine-protein kinase Lyn is a protein that in humans is encoded by the LYN gene. KIT (gene) and LYN are eC 2.7.10.
Lysosome
A lysosome is a single membrane-bound organelle found in many animal cells.
Mast cell
A mast cell (also known as a mastocyte or a labrocyte) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.
Mastocytoma
A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells.
See KIT (gene) and Mastocytoma
Megakaryocyte-associated tyrosine kinase
Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.
See KIT (gene) and Megakaryocyte-associated tyrosine kinase
Melanie Welham
Dame Melanie Joanne Welham (born 1964) is a British biochemist who was Executive Chair of the Biotechnology and Biological Sciences Research Council from April 2018 to June 2023.
See KIT (gene) and Melanie Welham
Melanocyte
Melanocytes are melanin-producing neural crest-derived cells located in the bottom layer (the stratum basale) of the skin's epidermis, the middle layer of the eye (the uvea), the inner ear, vaginal epithelium, meninges, bones, and heart found in many mammals and birds.
Melanoma
Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes.
MPDZ
Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.
Nilotinib
Nilotinib, sold under the brand name Tasigna marketed worldwide by Novartis, is a medication used to treat chronic myelogenous leukemia (CML) which has the Philadelphia chromosome.
Oncogene
An oncogene is a gene that has the potential to cause cancer.
Piebaldism
Piebaldism refers to the absence of mature melanin-forming cells (melanocytes) in certain areas of the skin and hair.
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.
Plerixafor
Plerixafor, sold under the brand name Mozobil, is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream.
Prostate
The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation.
Protein dimer
In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound.
See KIT (gene) and Protein dimer
Protein–protein interaction
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.
See KIT (gene) and Protein–protein interaction
Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene.
See KIT (gene) and Proto-oncogene tyrosine-protein kinase Src
PTPN11
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), Src homology region 2 domain-containing phosphatase-2 (SHP-2), or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene.
PTPN6
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.
Pyrrolobenzodiazepine
Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.
See KIT (gene) and Pyrrolobenzodiazepine
Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. KIT (gene) and receptor tyrosine kinase are eC 2.7.10 and tyrosine kinase receptors.
See KIT (gene) and Receptor tyrosine kinase
RTK class III
RTK class III is a class of receptor tyrosine kinases. KIT (gene) and RTK class III are tyrosine kinase receptors.
See KIT (gene) and RTK class III
S100 protein
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation.
See KIT (gene) and S100 protein
Seminoma
A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations.
SH2B2
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
SH2B3
SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12.
SOCS6
Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.
STAT1
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene.
Stem cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell.
Stem cell factor
Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117).
See KIT (gene) and Stem cell factor
Stromal cell-derived factor 1
The stromal cell-derived factor 1 (SDF-1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10.
See KIT (gene) and Stromal cell-derived factor 1
Suppressor of cytokine signaling 1
Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.
See KIT (gene) and Suppressor of cytokine signaling 1
TEC (gene)
Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene. KIT (gene) and TEC (gene) are genes on human chromosome 4.
Thymocyte
A thymocyte is an immune cell present in the thymus, before it undergoes transformation into a T cell.
Thymus
The thymus (thymuses or thymi) is a specialized primary lymphoid organ of the immune system.
Tyrosine-protein kinase Fes/Fps
Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.
See KIT (gene) and Tyrosine-protein kinase Fes/Fps
See also
EC 2.7.10
- CD135
- Hepatocyte growth factor receptor
- Insulin receptor
- KIT (gene)
- LYN
- Non-receptor tyrosine kinase
- Protein kinase R
- Receptor tyrosine kinase
- Soluble fms-like tyrosine kinase-1
- Src family kinase
- Tyrosine kinase
- Tyrosine kinase receptors
- Tyrosine kinases
Immunoglobulin superfamily cytokine receptors
- Colony stimulating factor 1 receptor
- IL18R1
- Interleukin 1 receptor, type II
- Interleukin-1 receptor
- Interleukin-18 receptor
- KIT (gene)
References
Also known as Anti-KIT, C Kit, C-KIT, C-kit receptor, CD117, CKIT, Proto-oncogene proteins c-kit, Stem cell factor receptor, Tyrosine kinase mutation, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.