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Atrimustine

Index Atrimustine

Atrimustine (developmental code name KM-2210; former tentative brand name Kregan), also known as bestrabucil or busramustine, is a nitrogen mustard alkylating antineoplastic drug that was under development in Japan by Kureha Chemicals (now Kureha Corporation) for the treatment of breast cancer and non-Hodgkin's lymphoma as well as for the prevention of graft-versus-host disease in bone marrow transplant recipients.https://adisinsight.springer.com/drugs/800000756 It is the benzoate ester of an ester conjugate of estradiol and chlorambucil, which results in targeted/site-directed DNA alkylating activity toward estrogen receptor-positive tissues such as breast and bone. It reached preregistration for the treatment of cancer but was ultimately discontinued. Estrogenicic side effects of atrimustine in clinical trials included vaginal bleeding and gynecomastia. The drug was first patented in 1980. [1]

25 relations: Alkylating antineoplastic agent, Benzoic acid, Bone, Breast, Breast cancer, Cancer, Chemotherapy, Chlorambucil, Clinical trial, Conjugated system, Ester, Estradiol, Estrogen (medication), Estrogen receptor, Graft-versus-host disease, Gynecomastia, Hematopoietic stem cell transplantation, Japan, Kureha Chemical Industries, List of hormonal alkylating antineoplastic agents, Marketing authorization, Nitrogen mustard, Non-Hodgkin lymphoma, Side effect, Vaginal bleeding.

Alkylating antineoplastic agent

An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA.

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Benzoic acid

Benzoic acid, C7H6O2 (or C6H5COOH), is a colorless crystalline solid and a simple aromatic carboxylic acid.

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Bone

A bone is a rigid organ that constitutes part of the vertebrate skeleton.

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Breast

The breast is one of two prominences located on the upper ventral region of the torso of primates.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Chlorambucil

Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Conjugated system

In chemistry, a conjugated system is a system of connected p-orbitals with delocalized electrons in molecules which are conventionally represented as having alternating single and multiple bonds, which in general may lower the overall energy of the molecule and increase stability.

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Ester

In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.

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Estradiol

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.

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Estrogen (medication)

An estrogen is a type of medication which is used most commonly in hormonal birth control and menopausal hormone therapy.

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Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

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Graft-versus-host disease

Graft-versus-host disease (GvHD) is a medical complication following the receipt of transplanted tissue from a genetically different person.

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Gynecomastia

Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.

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Hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.

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Japan

Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.

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Kureha Chemical Industries

Kureha Chemical Industries is a Japanese manufacturer of specialty chemicals and polymers.

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List of hormonal alkylating antineoplastic agents

This is a list of dual hormonal and alkylating antineoplastic agents.

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Marketing authorization

Process of reviewing and assessing the dossier to support a medicinal product in view of its marketing (also called licensing, registration, approval, etc.), finalized by granting of a document also called marketing authorization (MA) (equivalent: product license).

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Nitrogen mustard

Nitrogen mustards are cytotoxic chemotherapy agents derived from mustard gas.

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Non-Hodgkin lymphoma

Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Vaginal bleeding

Vaginal bleeding is any bleeding through the vagina, including bleeding from the vaginal wall itself, as well as (and more commonly) bleeding from another location of the female reproductive system, often the uterus.

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Redirects here:

Bestrabucil, Busramustine, Bustramustine, KM 2210, KM-2210, KM2210, Kregan.

References

[1] https://en.wikipedia.org/wiki/Atrimustine

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