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116 relations: Adrenergic antagonist, Agranulocytosis, Alpha-1 adrenergic receptor, Alpha-2 adrenergic receptor, Amine, Amitriptyline, Anticholinergic, Antihistamine, Ataxia, Atypical facial pain, Australia, Biological half-life, Biotransformation, Blood–brain barrier, Canada, CAS Registry Number, Chemical formula, Chemical nomenclature, Chemical structure, Clomipramine, Delusion, Demethylation, Depressant, Depression (mood), Dibenzothiepin, Diuretic, Doxepin, Drug overdose, Electrocardiography, English language, Eosinophilia, Epilepsy, Europe, Extrapyramidal symptoms, Feces, Free base, French language, Galactorrhea, German language, Glucuronidation, Glucuronide, Guanethidine, Gynecomastia, Hallucination, Hepatitis, Histamine, Histamine H1 receptor, Hong Kong, Hydrochloride, Hypomania, ..., Hyponatremia, Ileus, Imipramine, India, Indigestion, Italian language, Japan, Jaundice, Latin, Liver, Liver failure, Major depressive disorder, Malaysia, Metabolite, Molecular mass, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Myocardial infarction, New Zealand, Norepinephrine, Norepinephrine reuptake inhibitor, Norepinephrine transporter, Oral administration, Paresthesia, Peripheral neuropathy, Pharmacodynamics, Platelet, Racemic mixture, Receptor antagonist, Redox, Reuptake, Reuptake inhibitor, Ring (chemistry), Salt (chemistry), Serotonin, Serotonin receptor antagonist, Serotonin reuptake inhibitor, Serotonin syndrome, Serotonin transporter, Serotonin–norepinephrine reuptake inhibitor, Side chain, Singapore, Sodium channel, Sodium channel blocker, South Africa, Spanish language, Stereoisomerism, Stomatitis, Taiwan, Thrombocytopenia, Toxicity, Trademark distinctiveness, Tricyclic, Tricyclic antidepressant, Trimipramine, United Kingdom, United States, Urinary retention, Urine, 5-HT1A receptor, 5-HT2 receptor, 5-HT2A receptor. Expand index (66 more) »
Adrenergic antagonist
An adrenergic antagonist is a drug that inhibits the function of adrenergic receptors.
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Agranulocytosis
Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils causing a neutropenia in the circulating blood.
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Alpha-1 adrenergic receptor
The alpha-1 (α1) adrenergic receptor is a G protein-coupled receptor (GPCR) associated with the Gq heterotrimeric G-protein.
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Alpha-2 adrenergic receptor
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein.
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Amine
In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.
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Amitriptyline
Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.
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Anticholinergic
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system.
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Antihistamine
Antihistamines are drugs which treat allergic rhinitis and other allergies.
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Ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that includes gait abnormality.
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Atypical facial pain
Atypical facial pain (AFP) is a type of chronic facial pain which does not fulfill any other diagnosis.
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Australia
Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania and numerous smaller islands.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Biotransformation
Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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Canada
Canada is a country located in the northern part of North America.
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CAS Registry Number
A CAS Registry Number, also referred to as CASRN or CAS Number, is a unique numerical identifier assigned by the Chemical Abstracts Service (CAS) to every chemical substance described in the open scientific literature (currently including all substances described from 1957 through the present, plus some substances from the early or mid 1900s), including organic and inorganic compounds, minerals, isotopes, alloys and nonstructurable materials (UVCBs, of unknown, variable composition, or biological origin).
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Chemical formula
A chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs.
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Chemical nomenclature
A chemical nomenclature is a set of rules to generate systematic names for chemical compounds.
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Chemical structure
A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid.
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Clomipramine
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA).
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Delusion
A delusion is a mistaken belief that is held with strong conviction even in the presence of superior evidence to the contrary.
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Demethylation
Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule.
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Depressant
A depressant, or central depressant, is a drug that lowers neurotransmission levels, which is to depress or reduce arousal or stimulation, in various areas of the brain.
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Depression (mood)
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.
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Dibenzothiepin
Dibenzothiepins are chemical compounds which are derivatives of thiepin with two benzene (here called benzo) rings.
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Diuretic
A diuretic is any substance that promotes diuresis, the increased production of urine.
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Doxepin
Doxepin is a tricyclic antidepressant (TCA) used as a pill to treat major depressive disorder, anxiety disorders, chronic hives, and for short-term help with trouble remaining asleep after going to bed (a form of insomnia).
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Drug overdose
The term drug overdose (or simply overdose or OD) describes the ingestion or application of a drug or other substance in quantities greater than are recommended or generally practiced.
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Electrocardiography
Electrocardiography (ECG or EKG) is the process of recording the electrical activity of the heart over a period of time using electrodes placed on the skin.
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English language
English is a West Germanic language that was first spoken in early medieval England and is now a global lingua franca.
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Eosinophilia
Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds.
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Epilepsy
Epilepsy is a group of neurological disorders characterized by epileptic seizures.
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Europe
Europe is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere.
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Extrapyramidal symptoms
Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE), are drug-induced movement disorders that include acute and tardive symptoms.
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Feces
Feces (or faeces) are the solid or semisolid remains of the food that could not be digested in the small intestine.
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Free base
Free base (freebase, free-base) is the conjugate base (deprotonated) form of an amine, as opposed to its conjugate acid (protonated) form.
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French language
French (le français or la langue française) is a Romance language of the Indo-European family.
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Galactorrhea
Galactorrhea (also spelled galactorrhoea) (galacto- + -rrhea) or lactorrhea (lacto- + -rrhea) is the spontaneous flow of milk from the breast, unassociated with childbirth or nursing.
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German language
German (Deutsch) is a West Germanic language that is mainly spoken in Central Europe.
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Glucuronidation
Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.
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Glucuronide
A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.
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Guanethidine
Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.
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Gynecomastia
Gynecomastia is an endocrine system disorder in which a noncancerous increase in the size of male breast tissue occurs.
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Hallucination
A hallucination is a perception in the absence of external stimulus that has qualities of real perception.
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Hepatitis
Hepatitis is inflammation of the liver tissue.
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
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Histamine H1 receptor
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors.
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Hong Kong
Hong Kong (Chinese: 香港), officially the Hong Kong Special Administrative Region of the People's Republic of China, is an autonomous territory of China on the eastern side of the Pearl River estuary in East Asia.
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Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).
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Hypomania
Hypomania (literally "under mania" or "less than mania") is a mood state characterized by persistent disinhibition and elevation (euphoria).
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Hyponatremia
Hyponatremia is a low sodium level in the blood.
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Ileus
Ileus is a disruption of the normal propulsive ability of the gastrointestinal tract.
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Imipramine
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.
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India
India (IAST), also called the Republic of India (IAST), is a country in South Asia.
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Indigestion
Indigestion, also known as dyspepsia, is a condition of impaired digestion.
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Italian language
Italian (or lingua italiana) is a Romance language.
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Japan
Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.
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Jaundice
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and whites of the eyes due to high bilirubin levels.
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Latin
Latin (Latin: lingua latīna) is a classical language belonging to the Italic branch of the Indo-European languages.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Liver failure
Liver failure or hepatic insufficiency is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Malaysia
Malaysia is a federal constitutional monarchy in Southeast Asia.
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Metabolite
A metabolite is the intermediate end product of metabolism.
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Molecular mass
Relative Molecular mass or molecular weight is the mass of a molecule.
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Muscarinic acetylcholine receptor
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells.
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Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.
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Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor M2, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene.
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Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor, also known as cholinergic/acetylcholine receptor M3, or the muscarinic 3, is a muscarinic acetylcholine receptor encoded by the human gene CHRM3.
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Muscarinic acetylcholine receptor M4
The muscarinic acetylcholine receptor M4, also known as the cholinergic receptor, muscarinic 4 (CHRM4), is a protein that, in humans, is encoded by the CHRM4 gene.
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Muscarinic acetylcholine receptor M5
The human muscarinic acetylcholine receptor M5, encoded by the gene, is a member of the G protein-coupled receptor superfamily of integral membrane proteins.
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Myocardial infarction
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
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New Zealand
New Zealand (Aotearoa) is a sovereign island country in the southwestern Pacific Ocean.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
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Norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET).
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Oral administration
| name.
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Paresthesia
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.
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Peripheral neuropathy
Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Redox
Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.
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Reuptake
Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.
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Reuptake inhibitor
A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.
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Ring (chemistry)
In chemistry, a ring is an ambiguous term referring either to a simple cycle of atoms and bonds in a molecule or to a connected set of atoms and bonds in which every atom and bond is a member of a cycle (also called a ring system).
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Salt (chemistry)
In chemistry, a salt is an ionic compound that can be formed by the neutralization reaction of an acid and a base.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Serotonin receptor antagonist
A serotonin antagonist, or serotonin receptor antagonist, is a drug used to inhibit the action at serotonin (5-HT) receptors.
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Serotonin reuptake inhibitor
A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) by blocking the action of the serotonin transporter (SERT).
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Serotonin syndrome
Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.
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Side chain
In organic chemistry and biochemistry, a side chain is a chemical group that is attached to a core part of the molecule called "main chain" or backbone.
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Singapore
Singapore, officially the Republic of Singapore, is a sovereign city-state and island country in Southeast Asia.
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Sodium channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
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Sodium channel blocker
Sodium channel blockers are drugs which impair the conduction of sodium ions (Na+) through sodium channels.
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South Africa
South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa.
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Spanish language
Spanish or Castilian, is a Western Romance language that originated in the Castile region of Spain and today has hundreds of millions of native speakers in Latin America and Spain.
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Stereoisomerism
In stereochemistry, stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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Stomatitis
Stomatitis is inflammation of the mouth and lips.
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Taiwan
Taiwan, officially the Republic of China (ROC), is a state in East Asia.
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Thrombocytopenia
Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.
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Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.
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Trademark distinctiveness
Trademark distinctiveness is an important concept in the law governing trademarks and service marks.
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Tricyclic
Tricyclics are chemical compounds that contain three interconnected rings of atoms.
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Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
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Trimipramine
Trimipramine, sold under the brand name Surmontil among others, is a tricyclic antidepressant (TCA) which is used to treat depression.
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
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United States
The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.
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Urinary retention
Urinary retention is an inability to completely empty the bladder.
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Urine
Urine is a liquid by-product of metabolism in humans and in many animals.
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5-HT1A receptor
The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptor (5-HT receptor) that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT2 receptor
The 5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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Redirects here:
ATC code N06AA16, ATCvet code QN06AA16, Altapin, Depresym, Dopress, Dosulepin hydrochloride, Dosulepina, Dosulepine, Dosulepinum, Dosulépin, Dosulépine, Dothapax, Dothep, Dothiepin, Dothiepin hydrochloride, Dothiepine, IZ 914, IZ-914, IZ914, Idom, KS 1596, KS-1596, KS1596, Prepadine, Prothiaden, Prothiadene, Protiaden, Protiadene, Xerenal.
References
[1] https://en.wikipedia.org/wiki/Dosulepin
