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32 relations: Alpha helix, Antitarget, Arginine, C-terminus, Cardiac action potential, Cardiac muscle, Cell membrane, Channelopathy, City of Hope National Medical Center, Crystallography, Diethyl ether, Drosophila, Duarte, California, Good laboratory practice, Heart arrhythmia, Heterologous, KcsA potassium channel, Long QT syndrome, Lysine, N-terminus, PAS domain, Potassium channel, Protein isoform, Protein–protein interaction, Schizophrenia Research Forum, Short QT syndrome, Torsades de pointes, University of Wisconsin–Madison, Voltage-gated potassium channel, West Hollywood, California, Whisky a Go Go, YWHAE.
Alpha helix
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
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Antitarget
In pharmacology, an antitarget (or off-target) is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects.
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Arginine
Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cardiac action potential
The cardiac action potential is a brief change in voltage (membrane potential) across the cell membrane of heart cells.
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Cardiac muscle
Cardiac muscle (heart muscle) is one of the three major types of muscle, the others being skeletal and smooth muscle.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Channelopathy
Channelopathies are diseases caused by disturbed function of ion channel subunits or the proteins that regulate them.
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City of Hope National Medical Center
City of Hope is a private, not-for-profit clinical research center, hospital and graduate medical school located in Duarte, California, United States.
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Crystallography
Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids (see crystal structure).
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Diethyl ether
Diethyl ether, or simply ether, is an organic compound in the ether class with the formula, sometimes abbreviated as (see Pseudoelement symbols).
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Drosophila
Drosophila is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.
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Duarte, California
Duarte is a city in Los Angeles County, California, United States.
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Good laboratory practice
In the experimental (non-clinical) research arena, the phrase good laboratory practice or GLP specifically refers to a quality system of management controls for research laboratories and organizations to ensure the uniformity, consistency, reliability, reproducibility, quality, and integrity of chemical (including pharmaceuticals) non-clinical safety tests; from physio-chemical properties through acute to chronic toxicity tests.
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Heart arrhythmia
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
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Heterologous
In medicine a heterologous transplant means 'between species' or 'from one species to another'.
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KcsA potassium channel
KcsA is a prokaryotic potassium channel from the soil bacteria ''Streptomyces lividans'' that has been studied extensively in ion channel research.
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Long QT syndrome
Long QT syndrome (LQTS) is a condition which affects repolarization of the heart after a heartbeat.
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Lysine
Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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PAS domain
A Per-Arnt-Sim (PAS) domain is a protein domain found in all kingdoms of life.
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Potassium channel
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Schizophrenia Research Forum
Schizophrenia Research Forum is a web knowledge environment dedicated to news, information resources, and discussion about research on schizophrenia.
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Short QT syndrome
Short QT syndrome is a genetic disease of the electrical system of the heart.
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Torsades de pointes
Torsades de pointes or torsade depointes (TdP or simply torsade(s)) (translated as "twisting of the points"), is a specific type of abnormal heart rhythm that can lead to sudden cardiac death.
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University of Wisconsin–Madison
The University of Wisconsin–Madison (also known as University of Wisconsin, Wisconsin, UW, or regionally as UW–Madison, or simply Madison) is a public research university in Madison, Wisconsin, United States.
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Voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential.
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West Hollywood, California
West Hollywood, occasionally referred to locally as WeHo, is a city in Los Angeles County, California, United States.
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Whisky a Go Go
Whisky a Go Go is a nightclub in West Hollywood, California.
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YWHAE
14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.
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Redirects here:
ERG1, Erg1, Ether-a-go-go potassium channels, HERG1, Herg, Herg1, Human Ether-à-go-go-Related Gene, KCNH2, KCNH2 (gene), Kv11.1, SQT1, Sqt1.
References
[1] https://en.wikipedia.org/wiki/HERG
