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32 relations: Acetate, Agonist, Analgesic, Blood–brain barrier, C-terminus, Central nervous system, Clinical trial, Drug tolerance, Frakefamide, Half-life, Heavy legs, Hypoventilation, International nonproprietary name, Intramuscular injection, Κ-opioid receptor, Ligand (biochemistry), Liver, Met-enkephalin, N-terminus, Nasal congestion, Opioid peptide, Pain management, Peptide, Phases of clinical research, Physical dependence, Potency (pharmacology), Protein primary structure, Proteolysis, Seizure threshold, Side effect, Systemic administration, United States Adopted Name.
Acetate
An acetate is a salt formed by the combination of acetic acid with an alkaline, earthy, metallic or nonmetallic and other base.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Drug tolerance
Drug tolerance is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.
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Frakefamide
Frakefamide (INN) is a synthetic, fluorinated opioid tetrapeptide with the amino acid sequence Tyr-D-Ala-(p-F)Phe-Phe-NH2 which acts as a peripherally-specific, selective μ-opioid receptor agonist.
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Half-life
Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.
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Heavy legs
Heavy legs (jambes lourdes) is an alleged medical condition, described as an "unpleasant sensation of pain and heaviness" in the lower limbs.
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Hypoventilation
Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate (hypo meaning "below") to perform needed gas exchange.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Intramuscular injection
Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.
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Κ-opioid receptor
The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Met-enkephalin
Met-enkephalin, also known as metenkefalin (INN), sometimes referred to as opioid growth factor (OGF), is a naturally occurring, endogenous opioid peptide that has opioid effects of a relatively short duration.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Nasal congestion
Nasal congestion is the blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels.
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Opioid peptide
Opioid peptides are peptides that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides.
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Pain management
Pain management, pain medicine, pain control or algiatry, is a branch of medicine employing an interdisciplinary approach for easing the suffering and improving the quality of life of those living with chronic pain The typical pain management team includes medical practitioners, pharmacists, clinical psychologists, physiotherapists, occupational therapists, physician assistants, nurses.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Phases of clinical research
The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment.
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Physical dependence
Physical dependence is a physical condition caused by chronic use of a tolerance forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.
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Potency (pharmacology)
In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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Protein primary structure
Protein primary structure is the linear sequence of amino acids in a peptide or protein.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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Seizure threshold
The term seizure threshold is used to describe the balance between excitatory and inhibitory forces in the brain which affect how susceptible a person is to seizures.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Systemic administration
Systemic administration is a route of administration of medication, nutrition or other substance into the circulatory system so that the entire body is affected.
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United States Adopted Name
United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.
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Redirects here:
LY 127623, LY-127,623, LY-127623, Metkefamid, Metkefamid acetate, Metkefamide acetate, Metkephamid, Metkephamid acetate, Metkephamide, Metkephamide acetate.
References
[1] https://en.wikipedia.org/wiki/Metkefamide
