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22 relations: Aggression, Agitation (dementia), Allosteric modulator, Alzheimer's disease, AMPA receptor, AMPA receptor positive allosteric modulator, Clinical trial, Cognition, Congener (chemistry), Convulsion, CX-516, Eli Lilly, Farampator, Ionotropic glutamate receptor, LY-404187, LY-503430, Memory, Motor coordination, Motor disorder, Neurotoxicity, PF-04958242, Toxicity.
Aggression
Aggression is overt, often harmful, social interaction with the intention of inflicting damage or other unpleasantness upon another individual.
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Agitation (dementia)
Agitation often accompanies dementia and often precedes the diagnosis of common age-related disorders of cognition such as Alzheimer's disease (AD).
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Allosteric modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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AMPA receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS).
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AMPA receptor positive allosteric modulator
AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Cognition
Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".
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Congener (chemistry)
In chemistry, congeners are related chemical substances "related to each other by origin, structure, or function".
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Convulsion
A convulsion is a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body.
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CX-516
CX-516 is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator and is being developed by a collaboration of Cortex and Shire and Servier.
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Eli Lilly
Eli Lilly (July 8, 1838 – June 6, 1898) was an American soldier, pharmacist, chemist, and businessman who founded the Eli Lilly and Company pharmaceutical corporation.
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Farampator
Farampator (developmental code names CX-691, ORG-24448, SCH-900460) is an ampakine drug.
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Ionotropic glutamate receptor
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.
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LY-404187
LY-404187 is an AMPA receptor positive allosteric modulator which was developed by Eli Lilly and Company.
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LY-503430
LY-503430 is an AMPA receptor positive allosteric modulator developed by Eli Lilly.
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Memory
Memory is the faculty of the mind by which information is encoded, stored, and retrieved.
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Motor coordination
Motor coordination is the combination of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions.
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Motor disorder
Motor disorders are disorders of the nervous system that cause abnormal and involuntary movements.
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Neurotoxicity
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system.
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PF-04958242
PF-04958242 is a positive allosteric modulator (PAM) of the AMPA receptor (AMPAR), an ionotropic glutamate receptor, which is under development by Pfizer for the treatment of cognitive symptoms in schizophrenia.
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Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.
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Redirects here:
LY 451,395, LY 451395, LY-451,395, LY-451395, LY451,395, LY451395.
References
[1] https://en.wikipedia.org/wiki/Mibampator
