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17 relations: Allosteric modulator, Alzheimer's disease, AMPA receptor, AMPA receptor positive allosteric modulator, Brain-derived neurotrophic factor, Depression (mood), Eli Lilly and Company, Hippocampus, MPTP, Neuroprotection, Nootropic, Oral administration, Oxidopamine, Parkinson's disease, Schizophrenia, Striatum, Substantia nigra.
Allosteric modulator
In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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AMPA receptor
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS).
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AMPA receptor positive allosteric modulator
AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPR), a type of ionotropic glutamate receptor which mediates most fast synaptic neurotransmission in the central nervous system.
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Brain-derived neurotrophic factor
Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.
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Depression (mood)
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, tendencies, feelings, and sense of well-being.
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Eli Lilly and Company
Eli Lilly and Company is a global pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries.
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Hippocampus
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
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MPTP
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.
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Neuroprotection
Neuroprotection refers to the relative preservation of neuronal structure and/or function.
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Nootropic
Nootropics, also known as smart drugs and cognitive enhancers, are drugs, supplements, and other substances that purport to improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals.
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Oral administration
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Oxidopamine
Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Striatum
The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.
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Substantia nigra
The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.
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