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L 663536 is a leukotriene antagonist. [1]

4 relations: Antileukotriene agents, Arachidonate 5-lipoxygenase, Atherosclerosis, 5-lipoxygenase-activating protein.

An antileukotriene agent is a drug which functions as a leukotriene-related enzyme inhibitor (of arachidonate 5-lipoxygenase) or leukotriene receptor antagonist (of CysLT1) and consequently opposes the function of leukotrienes, which are fatty compounds produced by the immune system that promote bronchoconstriction, inflammation, microvascular permeability, and mucus secretion in asthma and COPD.

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Arachidonate 5-lipoxygenase, also known as 5-lipoxygenase, 5-LOX or 5-LO, is an enzyme that in humans is encoded by the ALOX5 gene.

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Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of arteriosclerosis in which an artery wall thickens as a result of invasion and accumulation of white blood cells (WBCs) (foam cell) and proliferation of intimal smooth muscle cell creating a fibrofatty plaque.

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Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene.

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Redirects here:

L-663,536, MK 886, MK-886.


[1] https://en.wikipedia.org/wiki/L_663536

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