35 relations: Alternative splicing, Apoptosis, Artificial cardiac pacemaker, Atrioventricular block, Cardiac muscle, Caspase, Cell nucleus, Dilated cardiomyopathy, Electron microscope, Endoplasmic reticulum, Farnesyltransferase inhibitor, Heart arrhythmia, Heart failure, Heptad repeat, Homology (biology), Immunolabeling, Implantable cardioverter-defibrillator, Inner nuclear membrane protein, Intermediate filament, Isoelectric point, Laminopathy, Maturation promoting factor, Mitosis, Nuclear lamina, Nuclear localization sequence, Nuclear pore, Phagocyte, Phosphatase, Point mutation, Post-translational modification, Programmed cell death, Scleroprotein, Sinoatrial node, Transcription (biology), Ventricular tachycardia.
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
A pacemaker (or artificial pacemaker, so as not to be confused with the heart's natural pacemaker) is a medical device that generates electrical impulses delivered by electrodes to contract the heart muscles and regulate the electrical conduction system of the heart.
Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and ventricles of the heart is impaired.
Cardiac muscle (heart muscle) is one of the three major types of muscle, the others being skeletal and smooth muscle.
Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively.
An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination.
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly abnormally active in cancer.
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.
The heptad repeat is an example of a structural motif that consists of a repeating pattern of seven amino acids: where H represents hydrophobic residues, C represents, typically, charged residues, and P represents polar (and, therefore, hydrophilic) residues.
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
Immunolabeling is a biochemical process that enables the detection and localization of an antigen to a particular site within a cell, tissue, or organ.
An implantable cardioverter-defibrillator (ICD) or automated implantable cardioverter defibrillator (AICD) is a device implantable inside the body, able to perform cardioversion, defibrillation, and (in modern versions) pacing of the heart.
Inner nuclear membrane (INM) proteins are proteins that are embedded in or associated with the inner membrane of the nuclear envelope (NE).
Intermediate filaments (IFs) are cytoskeletal components found in the cells of vertebrate animal species, and perhaps also in other animals, fungi, plants, and unicellular organisms.
The isoelectric point (pI, pH(I), IEP), is the pH at which a particular molecule carries no net electrical charge or is electrically neutral in the statistical mean.
Laminopathies (lamino- + -opathy) are a group of rare genetic disorders caused by mutations in genes encoding proteins of the nuclear lamina.
Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-Cdk complex that was discovered first in frog eggs.
In cell biology, mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.
The nuclear lamina is a dense (~30 to 100 nm thick) fibrillar network inside the nucleus of most cells.
A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.
Nuclear pore complexes are large protein complexes that span the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus.
Phagocytes are cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells.
A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.
A point mutation is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA.
Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.
Programmed cell death (or PCD) is the death of a cell in any form, mediated by an intracellular program.
Scleroproteins or fibrous proteins constitute one of the three main types of proteins (alongside globular and membrane proteins).
The sinoatrial node (SA node), also known as sinus node, is a group of cells located in the wall of the right atrium of the heart.
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
Ventricular tachycardia (V-tach or VT) is a type of regular and fast heart rate that arises from improper electrical activity in the ventricles of the heart.