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Levomefolic acid

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Levomefolic acid (INN) (also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. [1]

31 relations: Antidepressant, Atypical antipsychotic, Cerefolin, Colorectal cancer, Combination therapy, Cysteine, DNA, Fluorouracil, Folate, Homocysteine, International nonproprietary name, Merck Group, Metanx, Methionine, Methionine synthase, Methylation, Methylenetetrahydrofolate reductase, Orders of magnitude (mass), Pamlab, Route of administration, S-Adenosyl methionine, Salt (chemistry), Selective serotonin reuptake inhibitor, Serotonin–norepinephrine reuptake inhibitor, Switzerland, Tetrahydrofolic acid, Therapy, Thymidylate synthase, United States District Court for the Eastern District of Texas, United States International Trade Commission, 5,10-Methylenetetrahydrofolate.

Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Atypical antipsychotic

The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.

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Cerefolin

Cerefolin is a prescription medication made by Pamlab that contains 5.635 mg of folate as L-methylfolate, 1 mg of vitamin B12 as methylcobalamin, 50 mg of vitamin B2 as riboflavin, and 5 mg of vitamin B6 as pyridoxine.

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Colorectal cancer

Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).

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Combination therapy

Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone).

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Fluorouracil

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a medication used to treat cancer.

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Folate

Folate, distinct forms of which are known as folic acid, folacin, and vitamin B9, is one of the B vitamins.

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Homocysteine

Homocysteine is a non-proteinogenic α-amino acid.

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International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

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Merck Group

Merck KGaA, branded and commonly known as Merck, is a German multinational pharmaceutical, chemical and life sciences company headquartered in Darmstadt, with around 50,000 employees in around 70 countries.

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Metanx

Metanx is a prescription medical food made by Pamlab that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B9), methylcobalamin (vitamin B12) and pyridoxal 5'-phosphate (vitamin B6).

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Methionine

Methionine (symbol Met or M) is an essential amino acid in humans.

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Methionine synthase

Methionine synthase also known as MS, MeSe, MetH is responsible for the regeneration of methionine from homocysteine.

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Methylation

In the chemical sciences, methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group.

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Methylenetetrahydrofolate reductase

Methylene tetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene.

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Orders of magnitude (mass)

To help compare different orders of magnitude, the following lists describe various mass levels between 10−40 kg and 1053 kg.

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Pamlab

Alfasigma USA, Inc.

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Route of administration

A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body.

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S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

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Salt (chemistry)

In chemistry, a salt is an ionic compound that can be formed by the neutralization reaction of an acid and a base.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.

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Switzerland

Switzerland, officially the Swiss Confederation, is a sovereign state in Europe.

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Tetrahydrofolic acid

Tetrahydrofolic acid, or tetrahydrofolate, is a folic acid derivative.

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Therapy

Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.

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Thymidylate synthase

Thymidylate synthetase is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP).

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United States District Court for the Eastern District of Texas

The United States District Court for the Eastern District of Texas (in case citations, E.D. Tex.) is a federal court in the Fifth Circuit (except for patent claims and claims against the U.S. government under the Tucker Act, which are appealed to the Federal Circuit).

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United States International Trade Commission

The United States International Trade Commission (USITC, sometimes I.T.C.) is an independent, bipartisan, quasi-judicial, federal agency of the United States that provides trade expertise to both the legislative and executive branches.

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5,10-Methylenetetrahydrofolate

5,10-Methylenetetrahydrofolate (N5,N10-Methylenetetrahydrofolate; 5,10-CH2-THF) is the substrate used by the enzyme methylenetetrahydrofolate reductase (MTHFR) to generate 5-methyltetrahydrofolate (5-MTHF, or levomefolic acid).

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Redirects here:

5-MTHF, 5-Methyltetrahydrofolate, 5-methyltetrahydrofolate, 5-methyltetrahydrofolic acid, C20H25N7O6, Depelin, Deplin, L-methylfolate, Levomefolate calcium, MTHF, Metafolin, Methyl tetrahydrofolate, Methylfolate, Methyltetrahydrofolate, Neevo, NeevoDHA, Néevo, Zervalx.

References

[1] https://en.wikipedia.org/wiki/Levomefolic_acid

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