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Genetic linkage

Index Genetic linkage

Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. [1]

50 relations: Alfred Sturtevant, Allele, American Journal of Human Genetics, Bonferroni correction, Centimorgan, Chromatid, Chromosomal crossover, Chromosome, Coding region, Edith Rebecca Saunders, Gamete, Gametic phase, Gene, Gene map, Genetic association, Genetic epidemiology, Genetic linkage, Genetic marker, Genetic recombination, Genome-wide association study, Genotype, Gregor Mendel, Homologous chromosome, Homologous recombination, Identity by descent, Journal of Genetics, Lander–Green algorithm, Linkage disequilibrium, Meiosis, Mendelian inheritance, Microsatellite, Multiple comparisons problem, Nature Publishing Group, Newton Morton, Non-coding DNA, Nucleic acid sequence, P-value, Pedigree chart, Phenotype, Ploidy, Radiation reduced hybrid, Reginald Punnett, Restriction fragment length polymorphism, Sexual reproduction, Structural motif, Thomas Hunt Morgan, United Kingdom, W. H. Freeman and Company, William Bateson, Zygosity.

Alfred Sturtevant

Alfred Henry Sturtevant (November 21, 1891 – April 5, 1970) was an American geneticist.

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Allele

An allele is a variant form of a given gene.

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American Journal of Human Genetics

The American Journal of Human Genetics is a monthly peer-reviewed scientific journal in the field of human genetics.

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Bonferroni correction

In statistics, the Bonferroni correction is one of several methods used to counteract the problem of multiple comparisons.

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Centimorgan

In genetics, a centimorgan (abbreviated cM) or map unit (m.u.) is a unit for measuring genetic linkage.

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Chromatid

A chromatid (Greek khrōmat- 'color' + -id) is one copy of a newly copied chromosome which is still joined to the original chromosome by a single centromere.

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Chromosomal crossover

Chromosomal crossover (or crossing over) is the exchange of genetic material between homologous chromosomes that results in recombinant chromosomes during sexual reproduction.

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Chromosome

A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.

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Coding region

The coding region of a gene, also known as the CDS (from CoDing Sequence), is that portion of a gene's DNA or RNA that codes for protein.

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Edith Rebecca Saunders

Edith Rebecca Saunders (14 October 1865 – 6 June 1945) was a British geneticist and plant anatomist.

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Gamete

A gamete (from Ancient Greek γαμετή gamete from gamein "to marry") is a haploid cell that fuses with another haploid cell during fertilization (conception) in organisms that sexually reproduce.

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Gametic phase

In a diploid individual, the gametic phase represents the original allelic combinations that an individual received from its parents.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene map

Gene maps help describe the spatial arrangement of genes on a chromosome.

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Genetic association

Genetic association is when one or more genotypes within a population co-occur with a phenotypic trait more often than would be expected by chance occurrence.

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Genetic epidemiology

Genetic epidemiology is the study of the role of genetic factors in determining health and disease in families and in populations, and the interplay of such genetic factors with environmental factors.

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Genetic linkage

Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.

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Genetic marker

A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species.

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Genetic recombination

Genetic recombination (aka genetic reshuffling) is the production of offspring with combinations of traits that differ from those found in either parent.

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Genome-wide association study

In genetics, a genome-wide association study (GWA study, or GWAS), also known as whole genome association study (WGA study, or WGAS), is an observational study of a genome-wide set of genetic variants in different individuals to see if any variant is associated with a trait.

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Genotype

The genotype is the part of the genetic makeup of a cell, and therefore of an organism or individual, which determines one of its characteristics (phenotype).

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Gregor Mendel

Gregor Johann Mendel (Řehoř Jan Mendel; 20 July 1822 – 6 January 1884) was a scientist, Augustinian friar and abbot of St. Thomas' Abbey in Brno, Margraviate of Moravia.

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Homologous chromosome

A couple of homologous chromosomes, or homologs, are a set of one maternal and one paternal chromosome that pair up with each other inside a cell during meiosis.

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Homologous recombination

Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA.

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Identity by descent

A DNA segment is identical by state (IBS) in two or more individuals if they have identical nucleotide sequences in this segment.

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Journal of Genetics

The Journal of Genetics is a quarterly peer-reviewed scientific journal in the field of genetics and evolution.

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Lander–Green algorithm

The Lander–Green algorithm is an algorithm, due to Eric Lander and Philip Green for computing the likelihood of observed genotype data given a pedigree.

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Linkage disequilibrium

In population genetics, linkage disequilibrium is the non-random association of alleles at different loci in a given population.

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Meiosis

Meiosis (from Greek μείωσις, meiosis, which means lessening) is a specialized type of cell division that reduces the chromosome number by half, creating four haploid cells, each genetically distinct from the parent cell that gave rise to them.

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Mendelian inheritance

Mendelian inheritance is a type of biological inheritance that follows the laws originally proposed by Gregor Mendel in 1865 and 1866 and re-discovered in 1900.

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Microsatellite

A microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 1–6 or more base pairs) are repeated, typically 5–50 times.

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Multiple comparisons problem

In statistics, the multiple comparisons, multiplicity or multiple testing problem occurs when one considers a set of statistical inferences simultaneously or infers a subset of parameters selected based on the observed values.

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Nature Publishing Group

Nature Publishing Group is a division of the international scientific publishing company Springer Nature that publishes academic journals, magazines, online databases, and services in science and medicine.

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Newton Morton

Newton Ennis Morton (21 December 1929 – 7 February 2018) was an American population geneticist and one of the founders of the field of genetic epidemiology.

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Non-coding DNA

In genomics and related disciplines, noncoding DNA sequences are components of an organism's DNA that do not encode protein sequences.

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Nucleic acid sequence

A nucleic acid sequence is a succession of letters that indicate the order of nucleotides forming alleles within a DNA (using GACT) or RNA (GACU) molecule.

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P-value

In statistical hypothesis testing, the p-value or probability value or asymptotic significance is the probability for a given statistical model that, when the null hypothesis is true, the statistical summary (such as the sample mean difference between two compared groups) would be the same as or of greater magnitude than the actual observed results.

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Pedigree chart

A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next, most commonly humans, show dogs, and race horses.

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Phenotype

A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).

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Ploidy

Ploidy is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes.

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Radiation reduced hybrid

Radiation reduced hybrid is procedure in discovering the location of genetic markers relative to one another.

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Reginald Punnett

Reginald Crundall Punnett FRS (20 June 1875 – 3 January 1967) was a British geneticist who co-founded, with William Bateson, the Journal of Genetics in 1910.

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Restriction fragment length polymorphism

In molecular biology, restriction fragment length polymorphism (RFLP) is a technique that exploits variations in homologous DNA sequences.

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Sexual reproduction

Sexual reproduction is a form of reproduction where two morphologically distinct types of specialized reproductive cells called gametes fuse together, involving a female's large ovum (or egg) and a male's smaller sperm.

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Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.

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Thomas Hunt Morgan

Thomas Hunt Morgan (September 25, 1866 – December 4, 1945) was an American evolutionary biologist, geneticist, embryologist, and science author who won the Nobel Prize in Physiology or Medicine in 1933 for discoveries elucidating the role that the chromosome plays in heredity.

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United Kingdom

The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.

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W. H. Freeman and Company

W.

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William Bateson

William Bateson (8 August 1861 – 8 February 1926) was an English biologist who was the first person to use the term genetics to describe the study of heredity, and the chief populariser of the ideas of Gregor Mendel following their rediscovery in 1900 by Hugo de Vries and Carl Correns.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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References

[1] https://en.wikipedia.org/wiki/Genetic_linkage

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