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Lisdexamfetamine

Index Lisdexamfetamine

Lisdexamfetamine (contracted from L-'''lys'''ine-'''dex'''tro'''amphetamine''') is a substituted amphetamine and an inactive prodrug of the central nervous system (CNS) stimulant dextroamphetamine that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and binge eating disorder. [1]

70 relations: Absorption (pharmacology), Active metabolite, Adderall, Adjuvant therapy, Amfepramone, Amphetamine, Arteriosclerosis, Attention deficit hyperactivity disorder, Binge eating disorder, Bipolar disorder, Blood pressure, Bond cleavage, Capsule (pharmacy), Cardiovascular disease, Central nervous system, Chemical structure, Chemical synapse, Contraindication, Dextroamphetamine, Dopamine, Drug development, Enantiomer, Enzyme, Epileptic seizure, Essential amino acid, Excipient, Food and Drug Administration, Glaucoma, Half-life, Health Canada, Hydrolysis, Hypertension, Hyperthyroidism, Irritability, Levoamphetamine, Lysine, Major depressive disorder, Mania, Monoamine neurotransmitter, Monoamine oxidase inhibitor, Neurotransmitter, Norepinephrine, Off-label use, PH, Physical dependence, Prodrug, Psychological dependence, Psychosis, Raynaud syndrome, Red blood cell, ..., Reuptake, Selective serotonin reuptake inhibitor, Serotonin, Serotonin–norepinephrine reuptake inhibitor, Shire (pharmaceutical company), Sodium bicarbonate, Solubility, Stimulant, Stunted growth, Substance abuse, Substituted amphetamine, Synaptic vesicle, TAAR1, Therapeutic Goods Administration, Thyroid, Tic, Tourette syndrome, Treatment-resistant depression, Vesicular monoamine transporter 2, Vitamin C. Expand index (20 more) »

Absorption (pharmacology)

In pharmacology (and more specifically pharmacokinetics), absorption is the movement of a drug from the site of administration to bloodstream.

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Active metabolite

An active metabolite is an active form of a drug after it has been processed by the body.

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Adderall

Adderall, Adderall XR, and Mydayis are combination drugs containing four salts of the two enantiomers of amphetamine, a central nervous system (CNS) stimulant of the phenethylamine class.

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Adjuvant therapy

Adjuvant therapy, also known as adjunct therapy, add-on therapy, and adjuvant care, is therapy that is given in addition to the primary or initial therapy to maximize its effectiveness.

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Amfepramone

Amfepramone is a stimulant drug of the phenethylamine, amphetamine, and cathinone classes that is used as an appetite suppressant.

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Amphetamine

Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

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Arteriosclerosis

Arteriosclerosis is the thickening, hardening and loss of elasticity of the walls of arteries.

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Attention deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.

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Binge eating disorder

Binge eating disorder (BED) is an eating disorder characterized by frequent and recurrent binge eating episodes with associated negative psychological and social problems, but without subsequent purging episodes (e.g. vomiting).

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Bipolar disorder

Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.

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Blood pressure

Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.

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Bond cleavage

Bond cleavage, or scission, is the splitting of chemical bonds.

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Capsule (pharmacy)

In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories.

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Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Chemical structure

A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid.

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Chemical synapse

Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.

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Contraindication

In medicine, a contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient.

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Dextroamphetamine

Dextroamphetamine is a potent central nervous system (CNS) stimulant and amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

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Dopamine

Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.

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Drug development

Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.

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Enantiomer

In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).

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Enzyme

Enzymes are macromolecular biological catalysts.

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Epileptic seizure

An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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Essential amino acid

An essential amino acid, or indispensable amino acid, is an amino acid that cannot be synthesized ''de novo'' (from scratch) by the organism, and thus must be supplied in its diet.

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Excipient

An excipient is a substance formulated alongside the active ingredient of a medication, included for the purpose of long-term stabilization, bulking up solid formulations that contain potent active ingredients in small amounts (thus often referred to as "bulking agents", "fillers", or "diluents"), or to confer a therapeutic enhancement on the active ingredient in the final dosage form, such as facilitating drug absorption, reducing viscosity, or enhancing solubility.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Glaucoma

Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.

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Half-life

Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.

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Health Canada

Health Canada (Santé Canada) is the department of the government of Canada with responsibility for national public health.

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Hydrolysis

Hydrolysis is a term used for both an electro-chemical process and a biological one.

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Hypertension

Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Hyperthyroidism

Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland.

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Irritability

Irritability is the excitatory ability that living organisms have to respond to changes in their environment.

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Levoamphetamine

Levoamphetamine is a central nervous system (CNS) stimulant known to increase wakefulness and concentration in association with decreased appetite and fatigue.

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Lysine

Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Mania

Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability can be more pronounced and result in violence, or anxiety.

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Monoamine neurotransmitter

Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.

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Monoamine oxidase inhibitor

Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Off-label use

Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.

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PH

In chemistry, pH is a logarithmic scale used to specify the acidity or basicity of an aqueous solution.

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Physical dependence

Physical dependence is a physical condition caused by chronic use of a tolerance forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms.

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Prodrug

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.

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Psychological dependence

Psychological dependence is a form of dependence that involves emotional–motivational withdrawal symptoms (e.g., a state of unease or dissatisfaction, a reduced capacity to experience pleasure, or anxiety) upon cessation of drug use or exposure to a stimulus.

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Psychosis

Psychosis is an abnormal condition of the mind that results in difficulties telling what is real and what is not.

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Raynaud syndrome

Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which spasm of arteries cause episodes of reduced blood flow.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Reuptake

Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.

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Shire (pharmaceutical company)

Shire Plc is a Jersey-registered, Irish-headquartered global specialty biopharmaceutical company.

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Sodium bicarbonate

Sodium bicarbonate (IUPAC name: sodium hydrogen carbonate), commonly known as baking soda, is a chemical compound with the formula NaHCO3.

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Solubility

Solubility is the property of a solid, liquid or gaseous chemical substance called solute to dissolve in a solid, liquid or gaseous solvent.

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Stimulant

Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.

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Stunted growth

Stunted growth, also known as stunting and nutritional stunting, is a reduced growth rate in human development.

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Substance abuse

Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.

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Substituted amphetamine

Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.

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Synaptic vesicle

In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.

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TAAR1

Trace amine-associated receptor 1 (TAAR1) is a trace amine-associated receptor (TAAR) protein that in humans is encoded by the TAAR1 gene.

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Therapeutic Goods Administration

The Therapeutic Goods Administration (TGA) is the regulatory body for therapeutic goods (including medicines, medical devices, gene technology, and blood products) in Australia.

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Thyroid

The thyroid gland, or simply the thyroid, is an endocrine gland in the neck, consisting of two lobes connected by an isthmus.

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Tic

A tic is a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups.

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Tourette syndrome

Tourette syndrome (TS or simply Tourette's) is a common neuropsychiatric disorder with onset in childhood, characterized by multiple motor tics and at least one vocal (phonic) tic.

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Treatment-resistant depression

Treatment-resistant depression (TRD) or treatment-refractory depression is a term used in clinical psychiatry to describe cases of major depressive disorder (MDD) that do not respond adequately to appropriate courses of at least two antidepressants.

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Vesicular monoamine transporter 2

The vesicular monoamine transporter 2 (VMAT2) also known as solute carrier family 18 member 2 (SLC18A2) is a protein that in humans is encoded by the SLC18A2 gene.

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Vitamin C

Vitamin C, also known as ascorbic acid and L-ascorbic acid, is a vitamin found in food and used as a dietary supplement.

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Redirects here:

ATC code N06BA12, ATCvet code QN06BA12, C15H25N3O, Elvanse, Ldx, Lisdexamfetamine dimesylate, Lisdexamphetamine, Lisdextroamphetamine, Lysdexamfetamine, Lysdexamphetamine, VYVANSE, Vivance, Vivanse, Vyvance, Vyvanse.

References

[1] https://en.wikipedia.org/wiki/Lisdexamfetamine

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